Intracellular and Extracellular Responses of the Several Regions of the Mauthner Cell of the Goldfish

Furshpan, E. J.; Furukawa, Taro

doi:10.1152/jn.1962.25.6.732

Cited by 230 publications

(141 citation statements)

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“…8 A3,B3), estimated from its shunting effect on the AD spike, as shown previously (Furukawa and Furshpan, 1963;Faber and Korn, 1982;Oda et al, 1995). The accuracy of this estimate is supported by the fact that the AD spike of the M-cell propagates passively into the soma and dendrites (Furshpan and Furukawa, 1962). The data suggest that the inhibitory conductance suppresses action potentials after the initial spiking of M-cell.…”

Section: Mechanisms For the Transient Firing Property Of The M-cellsupporting

confidence: 78%

“…All procedures were performed in compliance with the guidelines stipulated by the Osaka University Committee on Animal Research. Fish were anesthetized with 0.015% 3-aminobenzoic acid ethyl ester (MS222; Sigma, St. Louis, MO), immobilized with D-tubocurarine chloride (2 g/gm body weight; Sigma), and held horizontally in a recording chamber with tapered rods at the head and body, as shown previously (Furshpan and Furukawa, 1962). During the experiment, fish were artificially respirated by gill perfusion with aerated water containing anesthetic (0.007% MS222).…”

Section: Methodsmentioning

confidence: 99%

“…We first located the M-cell axon cap, a glial structure surrounding the axon hillock, with the help of the antidromically evoked large negative field potential (see Fig. 4 A, bottom) (Furshpan and Furukawa, 1962). The locus of the maximum field potential of M-cell spikes (Ͼ30 mV) in the axon cap was used as a landmark for finding the RS neurons in r5 and r6.…”

Section: Methodsmentioning

confidence: 99%

“…This is attributable to a large voltage drop extracellularly within the axon cap (Fig. 4 A, bottom) and the electrical inexcitability of the somadendritic membrane of the M-cell (Furshpan and Furukawa, 1962). In MiD2cm, the onset latency of AD spikes ranged from 0.42 to 0.92 msec, with an average of 0.58 Ϯ 0.03 msec (17 cells) (Fig.…”

Section: Antidromic Responses Of the M-series Neuronsmentioning

confidence: 99%

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Common Sensory Inputs and Differential Excitability of Segmentally Homologous Reticulospinal Neurons in the Hindbrain

Nakayama¹,

Oda²

2004

J. Neurosci.

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Section: Mechanisms For the Transient Firing Property Of The M-cellsupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Antidromic Responses Of the M-series Neuronsmentioning

confidence: 99%

See 2 more Smart Citations

Common Sensory Inputs and Differential Excitability of Segmentally Homologous Reticulospinal Neurons in the Hindbrain

Nakayama¹,

Oda²

2004

J. Neurosci.

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“…Only in a few cases of simple reflexive behaviors have entire pathways been mapped from sensory to motor neurons (e.g., the tail-flip response in fish or touch avoidance in nematodes) (Furshpan and Furukawa, 1962;Chalfie et al, 1985). In comparison, the neural circuits that mediate the ability of animals to explore variable environments are poorly understood, because they perform more sophisticated transformations of sensory inputs into directed movements.…”

Section: Introductionmentioning

confidence: 99%

The AFD Sensory Neurons Encode Multiple Functions Underlying Thermotactic Behavior inCaenorhabditis elegans

et al. 2006

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The thermotactic behaviors of Caenorhabditis elegans indicate that its thermosensory system exhibits exquisite temperature sensitivity, long-term plasticity, and the ability to transform thermosensory input into different patterns of motor output. Here, we study the physiological role of the AFD thermosensory neurons by quantifying intracellular calcium dynamics in response to defined temperature stimuli. We demonstrate that short-term adaptation allows AFD to sense temperature changes as small as 0.05°C over temperature ranges as wide as 10°C. We show that a bidirectional thermosensory response (increasing temperature raises and decreasing temperature lowers the level of intracellular calcium in AFD) allows the AFD neurons to phase-lock their calcium dynamics to oscillatory thermosensory inputs. By analyzing the thermosensory response of AFD dendrites severed from their cell bodies by femtosecond laser ablation, we show that long-term plasticity is encoded as shifts in the operating range of a putative thermoreceptor(s) in the AFD sensory endings. Finally, we demonstrate that AFD activity is directly coupled to stimulation of its postsynaptic partner AIY. These observations indicate that many functions underlying thermotactic behavior are properties of one sensory neuronal type. Encoding multiple functions in individual sensory neurons may enable C. elegans to perform complex behaviors with simple neuronal circuits.

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Physiological properties of the mauthner system in the adult zebrafish

Hatta¹,

Korn²

1998

J. Comp. Neurol.

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We investigated the morphological and electrophysiological properties of the Mauthner (M-) cell and its networks in the adult zebrafish (Danio rerio) in comparison with those in the goldfish (Carassius auratus). The zebrafish M-cell has an axon cap, a high resistivity structure which surrounds the initial segment of the M-axon, and accounts for an unusual amplification of the fields generated within and around it. Second, extra- and intracellular recordings were performed with microelectrodes. The resting potential was approximately -80 mV with an input resistance of approximately 0.42 M omega. The M-cell extracellular field was large (10-20 mV), close to the axon hillock, and the latency of antidromic spikes short (approximately 0.4 milliseconds), confirming a high conduction velocity in the M-axon. The extrinsic hyperpolarizing potential (EHP), which signals firing of presynaptic cells and collateral inhibition, was markedly lower at frequencies of spinal stimulation > approximately 5/second, suggesting an organization of the recurrent collateral network similar to that in the goldfish. Inhibitory postsynaptic potentials (IPSPs) were highly voltage-dependent; their decay time constant was increased by depolarizations. The presynaptic neurons which are numerous could be identified by their passive hyperpolarizing potential (PHP) produced by the M-spike current. Auditory responses, mediated via mixed synapses (electrical and chemical), had short delays and hence are well suited to trigger the escape reaction. The similarities of their properties indicate that the wealth of information generated over decades in the goldfish can be extrapolated to the zebrafish.

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Intracellular and Extracellular Responses of the Several Regions of the Mauthner Cell of the Goldfish

Cited by 230 publications

References 0 publications

Common Sensory Inputs and Differential Excitability of Segmentally Homologous Reticulospinal Neurons in the Hindbrain

Common Sensory Inputs and Differential Excitability of Segmentally Homologous Reticulospinal Neurons in the Hindbrain

The AFD Sensory Neurons Encode Multiple Functions Underlying Thermotactic Behavior inCaenorhabditis elegans

Physiological properties of the mauthner system in the adult zebrafish

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