Intracellular accumulation of amino acids increases synaptic potentials in rat hippocampal slices

Luengo, Javier G.; Muñoz, Marı́a-Dolores; Álvarez-Merz, Iris; Herranz, Arantxa; Gonzalez, Jose; Rı́o, Rafael Martı́n del; Hernández‐Guijo, Jesús M.; Solís, José M.

doi:10.1007/s00726-019-02771-w

Cited by 11 publications

(8 citation statements)

References 53 publications

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“…There has been little recent research on D-threonine in the brain. The sole study has shown that D-threonine is transported into rat hippocampal slices, where it causes a potentiation of currents within those slices [ 21 ]. This occurs by a yet to be determined mechanism which mimics taurine potentiation but is independent of the NMAD receptor [ 21 , 124 , 125 ].…”

Section: Neuroactive D-isomers Without Direct Nmda Receptor Interamentioning

confidence: 99%

“…The sole study has shown that D-threonine is transported into rat hippocampal slices, where it causes a potentiation of currents within those slices [ 21 ]. This occurs by a yet to be determined mechanism which mimics taurine potentiation but is independent of the NMAD receptor [ 21 , 124 , 125 ]. Interestingly, it seems that many amino acids cause a similar potentiation including: L-alanine, D-alanine, L-glutamine, glycine, L-histidine, L-serine, D-serine, taurine, and L-threonine [ 21 ].…”

Section: Neuroactive D-isomers Without Direct Nmda Receptor Interamentioning

confidence: 99%

“…This occurs by a yet to be determined mechanism which mimics taurine potentiation but is independent of the NMAD receptor [ 21 , 124 , 125 ]. Interestingly, it seems that many amino acids cause a similar potentiation including: L-alanine, D-alanine, L-glutamine, glycine, L-histidine, L-serine, D-serine, taurine, and L-threonine [ 21 ]. It is known that taurine’s potentiation acts partially through the mitochondria, and further work would be needed to ascertain if D-threonine acts through improving mitochondrial function [ 125 ].…”

Section: Neuroactive D-isomers Without Direct Nmda Receptor Interamentioning

confidence: 99%

“…These are the most studied amino acids, and they are focused on a number of well-established disease models such as Alzheimer’s disease and schizophrenia [ 15 ]. The second are D-amino acids, which have NMDA receptor independent activities in the brain [ 18 , 19 , 20 , 21 , 22 ]. In many cases, these effects have only been recently discovered and they work through no unified mechanism or disease model [ 19 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…The second are D-amino acids, which have NMDA receptor independent activities in the brain [ 18 , 19 , 20 , 21 , 22 ]. In many cases, these effects have only been recently discovered and they work through no unified mechanism or disease model [ 19 , 21 , 22 ]. Finally, the third group consists of D-amino acids that are inert within the brain but have interesting derivative molecules or metabolites in the brain [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Advances in D-Amino Acids in Neurological Research

Seckler

Lewis

2020

IJMS

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D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to the brain and neurological disorders. This work has largely been focused on modulation of the N-methyl-D-aspartate (NMDA) receptor and its relationship to Alzheimer’s disease and Schizophrenia, but there has been a wealth of novel research which has elucidated a novel role for several D-amino acids in altering brain chemistry in a neuroprotective manner. D-amino acids which have no currently known activity in the brain but which have active derivatives will also be reviewed.

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