Intracardiac Ultrasound Catheter Imaging for Electrophysiologic Substrate of AV Nodal Reentrant Tachycardia:

Ren, Jian‐Fang; Marchlinski, Francis E.

doi:10.1046/j.1540-8167.2004.03588.x

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Intracardiac US imaging has been used for the diagnosis and treatment of multiple disorders in the electrophysiology laboratory [22]. The US-targeted MB destruction technique uses myocardial contrast echocardiography to target plasmid gene delivery to the myocardium and features low toxicity, limited immunogenicity, and the potential for repeated application [4,15,16].…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Transendocardial Delivery of HGF Via Microbubbles and Ultrasound to Treat Acute Myocardial Infarction

Yuan

Jing²,

Li³

et al. 2013

Current Gene Therapy

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To enhance the safety of transendocardial delivery and the efficacy of intramyocardial angiogenic gene expression, a visible, less invasive, targeted, high-efficiency gene delivery strategy was tested. Progress toward clinical approval of systemic administration of genes and microbubbles (MBs) has been limited. The feasibility of transendocardially delivering MBs as extracellular markers and gene carriers in conjunction with intracardiac ultrasound (US) treatment remains unknown. In a canine acute myocardial infarction (MI) model, a naked plasmid encoding 500 μg human hepatocyte growth factor (HGF) was delivered transendocardially to the myocardium via US/MB (HGF-US/MB), insonation (HGFUS), or alone (HGF alone). Control MI dogs received saline without US/MB (control group). During US/MB, intracardiac insonation was performed for 30 s with a 10-s pause, at 4.3-MHz, 1-W/cm(2), for 60 s at each site. Gene and MB distribution in the myocardium was visualized. Compared to the HGF alone group at 28 days, the HGF-US/MB group had an average 7.1-fold enhancement in gene expression (P < 0.01). Compared to the control group, there were 16% decreases in the ratio of left ventricle (LV) weight/body weight in the HGF-US/MB group and decreases in collagen volume fraction (CVF) of type I (33%) and type III (23%) collagen. Capillary density increased from 22.8 ± 6.3/mm(2) in the control group to 154.3 ± 42.9/mm(2) in the HGF-US/MB group (P < 0.01). This less invasive catheter-based US therapeutic procedure offers observable gene delivery with higher therapeutic efficiency, enhanced angiogenesis, and improved myocardial perfusion and ventricular function following MI.

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Section: Comparison With Other Studiesmentioning

confidence: 99%

Transendocardial Delivery of HGF Via Microbubbles and Ultrasound to Treat Acute Myocardial Infarction

Yuan

Jing²,

Li³

et al. 2013

Current Gene Therapy

View full text Add to dashboard Cite

show abstract

“…ICE heralds a novel era of catheter-based intracardiac ultrasound imaging technology. Additional improvement can be expected in the near future allowing multiplane and computer-reconstructed threedimensional imaging [43,44], which will provide more rapid and efficient diagnosis, guidance, and monitoring. Although there are no reported complications directly related to the use of the ultrasound catheter, further refinement and miniaturization will expand its clinical applications and ease of use of ICE imaging in diagnostic and therapeutic interventional electrophysiologic procedures, especially for ventricular tachyarrhythmia ablation directed at the ventricular endo-and/or epicardium.…”

Section: Future Directionsmentioning

confidence: 99%