Intracardiac thrombus: A risk of incomplete anticoagulation for cardiac operations

Cheung, Albert T.; Levin, Serle K.; Weiss, Stuart J.; Acker, Michael A.; Stenach, Nina

doi:10.1016/0003-4975(94)92249-7

Cited by 32 publications

(13 citation statements)

References 9 publications

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“…180,[187][188][189][190][191] However, the majority of these studies summarized in table 5, used short CPB intervals and were not powered adequately to clearly address safety of lower heparin doses with heparin-coated circuits with respect to thrombotic complications. 203 This has led Edmunds 204 to suggest that lowering heparin dose with heparin-coated circuits is inappropriate because of the lack of adequate safety data. 203 This has led Edmunds 204 to suggest that lowering heparin dose with heparin-coated circuits is inappropriate because of the lack of adequate safety data.…”

Section: Monitoring In Patients Undergoing Procedures Involving Use Omentioning

confidence: 99%

Anticoagulation Monitoring during Cardiac Surgery

et al. 1999

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The literature does not consistently support the importance of anticoagulation monitoring techniques during CPB. This is best reflected by studies that have evaluated the impact of the ACT method on blood loss and transfusion outcomes. Inconsistent findings from studies that evaluated the impact of ACT monitoring may be related to either suboptimal study design (i.e., retrospective, unblinded, nonrandomized) or possibly the diagnostic inprecision of the ACT method used in these studies. There are a small number of well-controlled studies, some of which suggest that bleeding and transfusion outcomes can be improved by refining heparin monitoring techniques, either by sustaining better anticoagulation during CPB or by optimizing protamine doses (i.e., when empiric protocols result in excessive protamine doses). More well-controlled studies are needed to better define the importance of anticoagulation management during CPB.

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Section: Monitoring In Patients Undergoing Procedures Involving Use Omentioning

confidence: 99%

Anticoagulation Monitoring during Cardiac Surgery

et al. 1999

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“…Our patient was already on warfarin due to chronic small vessel pulmonary thromboembolism but was Suboptimal from noncompliance issues. Suboptimal anti-coagulation and the risk of intracardiac thrombus formation have already been described in other cases of high-risk patients for intracardiac thrombi formation, such as cardiac surgery [16]. …”

Section: Discussionmentioning

confidence: 99%

Mobile Right Atrial Thrombi in a Patient with the Hemoglobin SC Disease

Savage

Ding

Eso

et al. 2011

Case Reports in Medicine

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“…[84][85][86][87][88] Supplementing ATIII during CPB might prevent this by decreasing thrombin generation and improving hemostatic outcome. 89 Many cardiac surgery patients present with acquired ATIII deficiency.…”

Section: Antithrombin III Deficiencymentioning

confidence: 99%

Genetics of Coagulation: Considerations for Cardiac Surgery

Morozowich

Donahue

Welsby

2006

Semin Cardiothorac Vasc Anesth

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Genetic variants in the coagulation system have been known since antiquity. Today, because of modern improvements in diagnosis and medical management, the clinician is likely to encounter a spectrum of coagulation factor deficiencies and identified polymorphic variants in the surgical population. Because perioperative hemorrhagic and thrombotic complications are potentially serious, it is important to understand the role that these defects and variants may play in predicting risk and optimizing patient management. The implications of coagulation genetics on the perioperative management of the cardiac surgery patient are reviewed.

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Intracardiac thrombus: A risk of incomplete anticoagulation for cardiac operations

Cited by 32 publications

References 9 publications

Anticoagulation Monitoring during Cardiac Surgery

Anticoagulation Monitoring during Cardiac Surgery

Mobile Right Atrial Thrombi in a Patient with the Hemoglobin SC Disease

Genetics of Coagulation: Considerations for Cardiac Surgery

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