Intracameral Voriconazole Injection in the Treatment of Fungal Endophthalmitis Resulting from Keratitis

Goyal, Jay; Fernandes, Merle; Shah, Sushmita G

doi:10.1016/j.ajo.2010.08.009

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…In addition, intravitreal voriconazole injections have been clinically effective in treatment of fungal endophthalmitis caused by Scedosporium apiospermum and Fusarium species [49]. In a recent retrospective study on fungal endophthalmitis, all 47 fungal isolates from eyes resulted sensitivity to intravitreal voriconazole, whereas only 69% of them were sensitive to intravitreal DAmB [50,51]. Levels of voriconazole in the first 8 h exceed about 10 times the MIC for fungal organisms causing endophthalmitis, as demonstrated in several PK studies [44,45].…”

Section: Intravitreal Azoles In Efementioning

confidence: 99%

“…Levels of voriconazole in the first 8 h exceed about 10 times the MIC for fungal organisms causing endophthalmitis, as demonstrated in several PK studies [44,45]. Nevertheless, since the half-life of voriconazole in the vitreous is only 2.5 h, the real concentration of the drug declines precipitously making it essential to repeat injections in order to maintain an adequate therapeutic level [42][43][44][45]50,51]. At the intravitreal level in in vivo models, a lower risk of retinal toxicity was associated with the use of voriconazole compared to the intravitreal DAmB.…”

Section: Intravitreal Azoles In Efementioning

confidence: 99%

“…At the intravitreal level in in vivo models, a lower risk of retinal toxicity was associated with the use of voriconazole compared to the intravitreal DAmB. In fact, up to high concentrations (such as 25 µg/mL) there were no histopathological or electroretinographic changes in the rat retinas [50,51]. Only at concentrations of 50 µg/mL or higher specific areas of necrosis could be highlighted [50,51], so it can be safely assumed that this drug can be used in humans up to even higher concentrations (up to at 100 µg) [44,45,50,51].…”

Section: Intravitreal Azoles In Efementioning

confidence: 99%

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Exogenous Fungal Endophthalmitis: Clues to Aspergillus Aetiology with a Pharmacological Perspective

et al. 2020

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Exogenous fungal endophthalmitis (EXFE) represents a rare complication after penetrating ocular trauma of previously unresolved keratitis or iatrogenic infections, following intraocular surgery such as cataract surgery. The usual latency period between intraocular inoculation and presentation of symptoms from fungal endophthalmitis is several weeks to months as delayed-onset endophthalmitis. Aspergillus spp., is the most common causative mould pathogen implicated in this ocular infection and early diagnosis and prompt antimicrobial treatment, concomitantly in most cases with expert surgical attention, reduce unfavorable complications and increase the possibility of eye function preservation. Topical, intravitreal and systemic antifungal molecules are the mainstay of a medical approach to the disease and azoles, polyenes and in particular cases echinocandins are the pharmacological classes most commonly used in clinical practice. This review discusses pharmacokinetics and pharmacodynamic of antifungal agents in their principal modes of administration with a focus on their ability to achieve high drug concentration in the vitreous and ocular tissues.

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Section: Intravitreal Azoles In Efementioning

confidence: 99%

Section: Intravitreal Azoles In Efementioning

confidence: 99%

Section: Intravitreal Azoles In Efementioning

confidence: 99%

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Exogenous Fungal Endophthalmitis: Clues to Aspergillus Aetiology with a Pharmacological Perspective

et al. 2020

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“…Endophthalmitis is by far one of the most catastrophic sight threatening diseases in ophthalmology. It is defined as an inflammation, almost always secondary to infection, affecting either the intraocular tissues or fluids (usually including the vitreous) [ 1 , 2 ]. Endophthalmitis are categorized into exogenous or endogenous, depending on the pathway by which the causative organism was introduced into the eye [ 3 , 4 ].…”

mentioning

confidence: 99%

Postoperative Exogenous Endophthalmitis Caused By Escherichia Coli: a Rare Case Report and Literature Review

et al. 2023

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Aim: We report a rare case of postoperative endophthalmitis caused by Escherichia coli. Case description: The diagnosis of postoperative endophthalmitis in our patient was established based on the clinical signs of hypopyon along with vitritis. The patient underwent pars plana vitrectomy, anterior chamber washout, intraocular lens removal, and intravitreal antibiotics (amikacin and vancomycin) injection. The culture of both the vitreous sample and the intraocular lens, revealed a heavy growth of Escherichia coli. Conclusion: Escherichia coli is an unusual microorganism to cause postoperative endophthalmitis. A major breach in the sterilization may explain this infection. Proper sterilization and prophylactic measures are crucial to avoid this disastrous complication.

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Toxicity of simultaneous intrastromal and intracameral injection of voriconazole on corneal endothelium in a rabbit model

Moon

Suh

Jun

et al. 2023

Cutaneous and Ocular Toxicology

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Intracameral Voriconazole Injection in the Treatment of Fungal Endophthalmitis Resulting from Keratitis

Cited by 3 publications

References 4 publications

Exogenous Fungal Endophthalmitis: Clues to Aspergillus Aetiology with a Pharmacological Perspective

Exogenous Fungal Endophthalmitis: Clues to Aspergillus Aetiology with a Pharmacological Perspective

Postoperative Exogenous Endophthalmitis Caused By Escherichia Coli: a Rare Case Report and Literature Review

Toxicity of simultaneous intrastromal and intracameral injection of voriconazole on corneal endothelium in a rabbit model

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