Intracameral cefazolin to prevent endophthalmitis in cataract surgery: 3-year retrospective study

Prophylactic intracameral vancomycin: efficacy in preventing endophthalmitis after cataract surgery

“…Later, Gimbel et al [13] reported no case of endophthalmitis in a series of 12,000 patients after using an infusion fluid of gentamicin together with vancomycin during cataract surgery. The choice of prophylactic antibiotics included cefuroxime, cefazolin and vancomycin based on the pattern of organisms, antibiotic resistance profile, cost and possible adverse effects [14][15][16][17][18][19].…”

Toxic Anterior Segment Syndrome (TASS) and Prophylaxis Against Postoperative Endophthalmitis

“…Furthermore, the concentration of these antibiotics used in irrigating solutions and the duration that they are in contact with bacteria responsible for endophthalmitis are not enough to be effective, based on their bactericidal or bacteriostatic characteristics (Peck et al, 2010). Other authors described the use of intracameral cefotaxime (Kramann et al, 2001), cefazolin (Garat et al, 2005) (Romero et al, 2006), and cefuroxime (Díez et al, 2009), but no toxicity has been reported. Nevertheless, there is always a possibility that these antibiotics could result in TASS due to an error in drug concentration or pH.…”

“…Intracameral cefazoline been reported to be used in several papers mainly from Spain. Its choice as a prophylactic agent for postoperative endophthalmitis is based on the bacteria cultures and antibiograms from their own cases and data published (Garat et al, 2005) (Romero et al, 2006). These authors believe that the first-generation cephalosporin cefazoline 1 mg in 0.1 ml of saline injected in anterior chamber has a broader spectrum of activity against gram-positive bacteria than the second-generation cefuroxime.…”

“…Cefazolin is bactericidal against gram-positive cocci, specially Staphylococcus (except for methicilin-resistant Staphylococci) and Streptococcus. Garat et al (Garat et al, 2005) use 2.5 mg/0.1 ml bolus which has proved to be effective reducing endophthalmitis rates from 0.422% to 0.047% and to be safe. Unfortunately, cefazoline-resistant bacteria such as Enterococcus constitute an important gap in the coverage of gram-negative bacteria with this antibiotic.…”

Aqueous humor penetration of fourth-generation fluoroquinolone ophthalmic solutions given by multiple administration in a rabbit model

“…[1][2][3][4][5][6][7][8][9][10] According to the European Society of Cataract and Refractive Surgeons (ESCRS) Endophthalmitis Study Group, intracameral cefuroxime administered at the time of surgery signifi cantly reduces the risk of the development of endophthalmitis after cataract surgery. 5 Meanwhile, several studies have investigated the infl uence on ocular tissue, especially corneal endothelial cells, of intracameral injections of various drugs, including triamcinolone acetonide, 0.5% moxifl oxacin, lidocaine, carbachol, and epinephrine.…”