Intrabronchial Neurilemmoma - Review of Cases in Japan

Shirakusa, Takayuki; Takada, Shinichi; Yamazaki, Shintaro; Ueda, Hisashi; Ando, Katsuhiro; Kusano, Toru; Eimoto, Tadatoshi

doi:10.1055/s-2007-1020361

Cited by 6 publications

(5 citation statements)

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“…Benign endobronchial tumors themselves are uncommon, and of these, endobronchial schwannoma is a rare entity, constituting approximately 2% of benign tracheobronchial tumors 9. Although rare, schwannomas can occur in any area of the tracheobronchial tree, with intraluminal or extraluminal extensions 7,10,11…”

Section: Discussionmentioning

confidence: 99%

Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases

et al. 2013

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BackgroundIt has long been recognized that bronchial schwannomas are extremely rare. As such, diagnosing tumors in this extraordinary location can sometimes be problematic.MethodsWe reviewed seven cases of bronchoscopically or surgically resected endobronchial schwannomas and evaluated their clinical and pathologic features.ResultsThe present study included five female and two male patients, with ages ranging from 16 to 81 years (mean age, 44.9 years). The clinical presentation varied according to tumor size and location. Patients with more centrally (trachea or main bronchus) located tumors experienced respiratory symptoms (80%) more often than patients with more peripherally (lobar or segmental bronchus) located tumors (0%). Histologically, the tumors were composed of spindle cells that stained with S100 protein. Some of the tumors showed typical Antoni A areas with Verocay body formation. Five of six patients (83.3%) underwent complete tumor removal by rigid bronchoscopy.ConclusionsPathologists should consider endobronchial schwannoma in the differential diagnosis of a spindle cell tumor involving the bronchus. Additionally, our results showed that rigid bronchoscopy is an effective tool for tumor removal in endobronchial schwannoma patients.

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Section: Discussionmentioning

confidence: 99%

Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases

et al. 2013

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“…We identified 33 cases of bronchial schwannoma among them (Table 2). [3–28] The process of selecting the cases is shown in Figure 3a. The median age was 48 years.…”

Section: Discussionmentioning

confidence: 99%

Primary bronchial schwannoma: A case report

et al. 2022

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Rationale: Bronchial schwannomas are extremely rare among the benign tracheobronchial tumors and little are known about its epidemiology and optimal clinical management. Here, we report a case of bronchial schwannoma in a young Japanese man and clinical implications about epidemiology, symptom, diagnosis, and treatment of bronchial schwannoma.Patients concern: A 37-year-old man visited our department with a nodule incidentally found on his chest radiograph during a routine medical checkup.Diagnosis: The tumor was diagnosed as a bronchial schwannoma after pathological evaluation. Microscopically, the tumor consisted of spindle cell proliferation characterized by an alternating highly ordered cellular Antoni A component with occasional nuclear palisading and a loose myxoid Antoni B component. Tumor cells were immunoreactive for S100 but not for smooth muscle actin or KIT.Interventions: A video-assisted right middle and lower bilobectomy was performed.Outcome: He remains under observation without recurrence.Lessons: In our review, many reports have come from Asian countries. Bronchial schwannoma can occur within a wide range of age groups and in both men and women. No difference in incidence was observed between right and left bronchial tree. Bronchial schwannoma is sometimes difficult to differentiate from malignant diseases. We should include bronchial schwannoma as one of the differential diagnoses of primary bronchial tumors.

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“…Neurogenic benign tumors arising from the tracheobronchial tree are relatively rare. 4 – 7 Benign lung tumors have been reported to account for 1.9 % of total lung tumors and most of them are papilloma (29%), hamartoma (24%) and angioma (10%). 8 The incidence of intrapulmonary neurogenic tumors was stated as 0.2% in a series of 1664 primary pulmonary tumors.…”

Section: Discussionmentioning

confidence: 99%