Intrabony Defects, Open‐Flap Debridement, and Decortication: A Randomized Clinical Trial

Crea, Alessandro; Deli, Giorgio; Littarru, Cristiano; Lajolo, Carlo; Orgeas, Gianluca Vittorini; Tatakis, Dimitris N.

doi:10.1902/jop.2013.120753

Cited by 30 publications

(32 citation statements)

References 43 publications

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“…Growth factors come from the graft, recipient bed and vasculature. It is believed that intramarrow penetration of recipient beds favors both cellular and growth factor migration into the sites where bone is regenerated, which is associated with up to 30% greater bone regeneration and higher bone density at grafted sites [34,35]. Osteoprogenitor cells from the host infiltrate the host within 7 days.…”

Section: Principles Of Bone Regenerationmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Section: Principles Of Bone Regenerationmentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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“…A requirement for bone regeneration is the recruitment or presence of osteoblast precursors and growth factors at sites of augmentation. Osteoblast precursors can be provided by the graft material (cancellous autogenous grafts) or by the recipient bed [21]. The early phase of bone regeneration is dominated by active bone resorption and formation throughout the graft.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials

et al. 2015

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Calcium phosphate ceramic materials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. In order for these biomaterials to work effectively it is imperative that they undergo the process of degradation and resorption in vivo. This allows for the space to be created for the new bone tissue to form and infiltrate within the implanted graft material. Several factors affect the biodegradation and resorption of calcium phosphate materials after implantation. Various cell types are involved in the degradation process by phagocytic mechanisms (monocytes/macrophages, fibroblasts, osteoblasts) or via an acidic mechanism to reduce the micro-environmental pH which results in demineralization of the cement matrix and resorption via osteoclasts. These cells exert their degradation effects directly or indirectly through the cytokine growth factor secretion and their sensitivity and response to these biomolecules. This article discusses the mechanisms of calcium phosphate material degradation in vivo.

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“…in 2014 had evaluated OFD along with OFD and IMP and found CAL gain of >2 mm in test site which was statistically significant; however, the percentage of DF was not determined. [ 22 ]…”

Section: Discussionmentioning

confidence: 99%

Treatment of horizontal defect with and without platelet-rich fibrin matrix: A randomized comparative clinical study

Debnath

Chatterjee

2018

J Indian Soc Periodontol

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Aim:The aim of the present study was to assess the clinical and radiographical parameters in horizontal bone defects in patients with chronic periodontitis.Materials and Methods:In this randomized, controlled clinical trial study, nine individuals with 94 sites having moderate to deep periodontitis were selected and distributed to Group A – open flap debridement (OFD), Group B – open flap debridement and intra marrow penetration (OFD + IMP) and Group C – Open flap debridement + Intramarrow penetration + platelet rich fibrin matrix (OFD + IMP + PRFM). Plaque index (PI) and gingival index (GI) were evaluated at baseline, 6 months, and 9 months after surgery. Probing pocket depth (PPD) and clinical attachment level (CAL) were recorded at baseline and 9 months after surgery. Radiographic assessment was carried out to measure the periodontal defect depth and defect fill percentage (DF%) at baseline and 9 months after the surgery using radiovisiography.Results:The statistical evaluation obtained after 9 months showed no significant difference between PI and GI at 9 months interval. Intergroup comparison of PPD and CAL has shown significant difference in Group C as compared to Group A and B with P < 0.05. The defect depth was statistically significant at 9 months in all the groups, and DF percentage (DF%) has shown statistically significant results in Group C as compared to A and B with P = of 0.001.Conclusion:The addition of PRFM to horizontal type of periodontal defects has shown promising results over a 9-month follow-up period.

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Intrabony Defects, Open‐Flap Debridement, and Decortication: A Randomized Clinical Trial

Abstract: Addition of IMP to an OFD procedure used to treat intrabony defects results in statistically and clinically significant enhancement of both clinical and radiographic outcomes.

Cited by 30 publications

References 43 publications

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials

Treatment of horizontal defect with and without platelet-rich fibrin matrix: A randomized comparative clinical study

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