Intraarticular Osteoid Osteoma Associated with Synovitis: A Possible Role of Cyclooxygenase-2 Expression by Osteoblasts in the Nidus

Kawaguchi, Yoji; Sato, Chubun; Hasegawa, Tadashi; Oka, Shiro; Kuwahara, Hiroko; Norimatsu, Hiromichi

doi:10.1038/modpathol.3880202

Cited by 53 publications

(44 citation statements)

References 25 publications

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“…9 The release of cyclooxygenase-2 by osteoblasts of the nidus causes synovitis in the setting of intra-articular OO. 10 The inflammatory response of the synovium may promote proliferation of chondrocytes with angiogenesis and promote migration of mesenchymal cells in the subchondral bone. These changes may ultimately lead to development of secondary osteoarthritis and joint destruction.…”

Section: Discussionmentioning

confidence: 99%

Arthroscopic Excision of Acetabular Osteoid Osteoma: Computer Tomography–Guided Approach

Tamam¹,

Howse²,

Tamam³

et al. 2015

Arthroscopy Techniques

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Osteoid osteoma is a benign osteoblastic tumor that occurs in the subcortical shaft and metaphysis of the long bones of the lower extremities; however, intra-articular lesions are also possible. Intra-articular osteoid osteomas are rare, and clinical symptoms are often less specific and, thereby, may lead to misdiagnosis. The definitive treatment for osteoid osteoma is the excision of the nidus. We present the case of a 23-year-old man with a 4-year history of right anterior hip pain, subsequently diagnosed with a subarticular osteoid osteoma located in the right anterior acetabulum. Hip arthroscopic excision of the juxta-articular osteoid osteoma is presented as an effective treatment, with the advantage of less potential damage to normal bone and cartilage, as well as the additional benefits available with hip arthroscopy.

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Section: Discussionmentioning

confidence: 99%

Arthroscopic Excision of Acetabular Osteoid Osteoma: Computer Tomography–Guided Approach

Tamam¹,

Howse²,

Tamam³

et al. 2015

Arthroscopy Techniques

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“…3,4 The nidus produces prostaglandins among other substances proposed to be responsible for pain and associated inflammation. 4,5 a small lucent nidus with central calcification surrounded by intense periosteal reaction and thick bony sclerosis. 6 The nidus is usually 5-10 mm in diameter located in the cortex of long bones.…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency ablation of osteoid osteoma using tissue impedance as a parameter of osteonecrosis

Al-Omari¹,

Ata

Al-Muqbel³

et al. 2012

J Med Imag Rad Onc

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Introduction: The aim of this study is to assess the safety and the efficacy of radiofrequency ablation (RFA) of osteoid osteoma with Soloist monopolar electrode using tissue impedance, rather than temperature, as an indicator of osteonecrosis. Methods: The medical records and imaging studies of 30 patients (males 18, females 12) who underwent RFA of osteoid osteoma at our institution were reviewed. The mean age of the patients was 15.3 years (range 5-34 years) and the mean duration of follow up was 26.9 months (range 3-52 months). The lesions were located in the femur (n = 6, 53%), tibia (n = 8, 27%), hand (n = 3, 10%), foot (n = 2, 6%) and humerus (n = 1, 3%). The procedure was performed with general anaesthesia under CT guidance. The nidus was accessed with 11-gauge bone biopsy needle and then the stylet was removed and replaced by monopolar 16.5G radiofrequency probe with a 9-mm active tip through the coaxial axis. Power delivery via the radiofrequency generator was started at 2 W and increased gradually until the end point of 450-500 W reached and 'Roll-Off' achieved indicating coagulation necrosis of the target lesion. Results: The procedure was technically successful in all patients. The mean procedure time was 72 min and the mean RFA time was 12.7 min. The clinical success rate was 93%. In one patient, the procedure was abandoned due to immature Roll-Off despite all measures. In one patient (3%), recurrence occurred 39 months after the procedure. No major complications were encountered. Two minor skin burns occurred that were resolved with conservative measures. Conclusion: RFA of osteoid osteoma using Soloist monopolar electrode is a safe and effective treatment. Tissue impedance could be used as an alternative to temperature to indicate osteonecrosis of osteoid osteoma during RFA.

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“…Osteoid osteoma, which is histologically similar to osteoblastoma in several aspects, also causes this inflammatory phenomenon, and in younger patients it tends to be associated with more extensive peritumoral edema (5,6). COX-2 expression, which is largely induced by inflammation, plays a key role in the activation of the arachidonic acid metabolic pathway and the production of PG (7,8). This finding on imaging is misleading and may cause overestimation of the tumor size and misdiagnosis of malignancy.…”

Section: Discussionmentioning

confidence: 91%

Activation of the arachidonic acid metabolic pathway and induction of sleep disturbance by sacral osteoblastoma: A case report

et al. 2017

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Abstract. Osteoblastomas are benign bone tumors that produce prostaglandin and promote inflammation. The aim of the present study was to describe the clinical and radiological characteristics of a pediatric osteoblastoma case over an 8-month postoperative follow-up. The case involved an 11-year-old female patient with normal somatic development, presenting with a chief complaint of sleep disturbance. The patient had no spontaneous pain or other readily evident possible causes. Magnetic resonance imaging (MRI) revealed a neoplastic lesion in the sacrum, with peritumoral edema. Intraoperative fast-frozen biopsy raised the suspicion of osteosarcoma. However, the final diagnosis was osteoblastoma and a second operation was performed for total resection. The edematous peritumoral bone and muscle tissues were preserved. Following total removal of the tumor, the sleep disturbance resolved. Eight months after the surgery, MRI revealed no recurrence of the tumor and reduction of the peritumoral edema. On immunohistochemical examination, cyclooxygenase (COX)-1 and COX-2 were strongly positive, indicating that the tumor activated the arachidonic acid metabolic pathway and produced prostaglandin. The inflammatory process subsequently promoted the development of peritumoral edema and induced the sleep disturbance.

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Intraarticular Osteoid Osteoma Associated with Synovitis: A Possible Role of Cyclooxygenase-2 Expression by Osteoblasts in the Nidus

Cited by 53 publications

References 25 publications

Arthroscopic Excision of Acetabular Osteoid Osteoma: Computer Tomography–Guided Approach

Arthroscopic Excision of Acetabular Osteoid Osteoma: Computer Tomography–Guided Approach

Radiofrequency ablation of osteoid osteoma using tissue impedance as a parameter of osteonecrosis

Activation of the arachidonic acid metabolic pathway and induction of sleep disturbance by sacral osteoblastoma: A case report

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