Intraarterial infusion of 5-fluoro-2-deoxyuridine-C8 dissolved in a lymphographic agent in malignant liver tumors. A preliminary report

Yamashita, Yasuyuki; Takahashi, Manabu; Bussaka, H.; Fukushima, Shoji; Kawaguchi, Takeo; Nakano, Masahiro

doi:10.1002/1097-0142(19891215)64:12<2437::aid-cncr2820641207>3.0.co;2-h

Cited by 28 publications

(7 citation statements)

References 18 publications

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“…Lipiodol has the interesting property of having a very selective deposition within HCC in which it remains for several months after intraarterial bolus injection, whereas it quickly disappears from the cirrhotic nontumorous parenchyma (22,(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). This is helpful for diagnosis and intrahepatic extension evaluation of HCC when a CT scan is performed 1 to 2 wk after injection (30,31,33,34).…”

Section: Discussionmentioning

confidence: 99%

“…This is helpful for diagnosis and intrahepatic extension evaluation of HCC when a CT scan is performed 1 to 2 wk after injection (30,31,33,34). Moreover, lipiodol acts as a selective carrier for internal radiotherapy with 1-131 (26)(27)(28), for the liposoluble styrene-maleic-acid-neocarzinostatin (29,301, 5-fluoro-deoxyuridin (39) and emulsified hydrosoluble agents such as doxorubicin (26,33,(35)(36)(37), mitomycin C (26,33,37), epirubicin (5) or cisplatin (36,38,40). The benefit of lipiodolization to survival has been clearly demonstrated in large-scale Asiatic trials (26,29,35,37,38); it has been shown to be vastly superior to systemic chemotherapy, embolization or chemoembolization (9, 13,16,23,25,29,35,36).…”

Section: Discussionmentioning

confidence: 99%

“…This is comparable to the use of biodegradable microspheres containing the drug (9, 25). More recently, lipiodolization using the ethiodized oil as a specific carrier either for internal radiotherapy with 1-131 (26)(27)(28) or for antitumor drugs (22,26,(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) has appeared to be more efficient. Lipiodol-targeted chemotherapy is optimized by coupling it with embolization (32-34, 36, 37, 40).…”

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confidence: 99%

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Transcatheter oily chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: Results of a western comparative study in 60 patients

Vetter¹,

Wenger²,

Bergier³

et al. 1991

Hepatology

120

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Transcatheter oily chemoembolization is widely used as palliative therapy for inoperable hepatocellular carcinoma in high-incidence Asiatic areas. To assess its usefulness in the Western form of this cancer, 30 French patients were treated between 1987 and 1990 by intraarterial hepatic injection of a Lipiodol-doxorubicin emulsion followed by embolization with 0.5 to 1 mm gelatin sponge particles. The number of procedures ranged from one to five. All patients had advanced, symptomatic and inoperable hepatocellular carcinoma (Okuda's staging: I, n = 8; II, n = 14; III, n = 8); none was found under systematic screening. All had underlying cirrhosis (Child-Pugh's class: A, n = 15; B, n = 12; C, n = 3) that was alcoholic in origin in 27 cases and posthepatitic B in origin in 3 cases. The results of the treatment were assessed by comparison with a group of 30 untreated patients admitted to the same unit between 1984 and 1987. Patients of both groups were closely matched for clinical presentation, global disease staging and precise anatomical extension. The overall 1- and 2-yr survival rate was 59% and 30%, respectively, for the treated patients vs. 0% at 1 yr for the untreated patients. The latter all died from local disease with end-stage liver failure and/or uncontrollable variceal bleeding. In the former, the three patients with Child's class C cirrhosis died after the first procedure. During the follow-up (range = 3 to 26 mo), 11 additional patients died, 8 from metastatic generalization.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Transcatheter oily chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: Results of a western comparative study in 60 patients

Vetter¹,

Wenger²,

Bergier³

et al. 1991

Hepatology

120

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“…4) Numerous studies have reported that Lipiodol selectively delivers various antitumor drugs to tumors. [5][6][7][8][9] SMANCS, amphipathic polymer styrene maleic acid neocarzinostatin, was developed as an anticancer drug for use in this therapy. 5,[10][11][12] The widespread clinical use of SMANCS has revealed areas of effectiveness and a few problems.…”

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confidence: 99%

In vitro Antitumor Activity, Intracellular Accumulation, and DNA Adduct Formation of cis‐[((1R, 2R)‐1,2‐Cyclohexanediamine‐N, N')bis(myristato)] Platinum (II) Suspended in Lipiodol

Kishimoto

Miyazawa

Fukushima

et al. 2000

Japanese Journal of Cancer Research

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SM-11355, cis-[((1R,2R)-1,2-cyclohexanediamine-N,N′ ′ ′ ′)bis(myristato)] platinum (II), is a lipophilicplatinum complex under clinical development that targets primary hepatocellular carcinoma using Lipiodol as a carrier. SM-11355 was compared with cisplatin (CDDP) using an in vitro evaluation system capable of examining the release characteristics and the cytotoxicity of drugs suspended in Lipiodol. SM-11355 suspended in Lipiodol (SM-11355/Lipiodol) and CDDP suspended in Lipiodol (CDDP/Lipiodol) showed cytotoxic activity against rat ascites hepatoma AH-109A cells in a dosedependent manner. Their IC 50 values following 7-day exposure were 22.3 and 0.40 µ µ µ µg/ml, respectively. Following the subsequent 7-day exposure, from day 7 to day 14 after preparation of the suspension, SM-11355/Lipiodol showed an almost equivalent activity, but CDDP/Lipiodol did not show any activity at all. SM-11355/Lipiodol showed a sustained release into the culture medium over the course of a 14-day exposure. Following the exposure to CDDP/Lipiodol, the platinum concentration in the medium was at its maximum on the first day and remained constant thereafter. Intracellular platinum uptake and formation of platinum-DNA adducts were dependent on the release characteristics of each drug suspension. For SM-11355/Lipiodol, the drug release, intracellular drug uptake, and formation of platinum-DNA adducts over the course of the subsequent 7-day exposure were similar to those observed during the first 7 days. DPC, one of the compounds released from SM-11355/Lipiodol, was taken up by cells and showed formation of platinum-DNA adducts. Thus, this study suggests that SM-11355/Lipiodol may release active platinum compound(s) that bind to nuclear DNA and mediate the cytotoxic activity of SM-11355/Lipiodol.Key words: Lipiodol -Cisplatin -Hepatocellular carcinoma -Sustained release Primary hepatocellular carcinoma therapy has improved as a result of advances made in hepatic arterial infusion chemotherapy.1-3) As Lipiodol, an oily lymphographic agent, is selectively retained in hepatic tumor tissue when injected into the hepatic artery, it has been used both in the diagnosis and therapy of hepatic cancer. 4) Numerous studies have reported that Lipiodol selectively delivers various antitumor drugs to tumors. 5-9) SMANCS, amphipathic polymer styrene maleic acid neocarzinostatin, was developed as an anticancer drug for use in this therapy. 5, 10-12)The widespread clinical use of SMANCS has revealed areas of effectiveness and a few problems. CDDP, cisplatin, is reportedly highly effective against various carcinomas, and when suspended in Lipiodol (CDDP/Lipiodol) is effective against hepatocellular carcinoma. 7, 13) However, therapeutic problems associated with CDDP/Lipiodol include an insufficient anticancer effect and adverse effects resulting from both inadequate stability of the suspension and rapid release of the drug.SM-11355 has been developed as a lipophilic platinum complex that has the added feature of lipophilicity, which makes this anticancer...

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“…Yamashita et al 44) intra-arterially infused the prodrug dissolved in a lymphographic agent to patients suŠering from malignant liver tumors and found reduction in serum tumor markers such as afetoprotein (Fig. 5) and carcinoembryonic antigen.…”

Section: ) Microspheres Containing Aclarubicin For Use As Suspensionsmentioning

confidence: 99%

From Physical Pharmacy to Clinical Pharmacology

Nakano

2005

YAKUGAKU ZASSHI

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Research works on molecular interactions in solutions were carried out at School of Pharmacy, the University of Wisconsin under the direction of Prof. T. Higuchi and at Faculty of Pharmaceutical Sciences, Kyoto University under the direction of Prof. H. Sezaki. Studies on permeation of drugs through polymer membranes were carried out at Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada and at Pharmaceutical Chemistry Research Laboratories at Food and Drug Directorate, Department of Health and Welfare, Canada. Studies on modiˆcation of delivery patterns by means of pharmaceutical approaches were carried out at Faculty of Pharmaceutical Sciences, Hokkaido University. Topics related to modiˆcation of drug delivery patterns include employment of amorphous forms such as ground mixture with micro-crystalline cellulose and coprecipitate with polyvinylpyrrolidone, use of biodegradable polymers such as polylactic acid and polycarbonates, gel-forming materials such as konjac, agar and hydroxypropylcellulose, and physicochemical systems such as complexation. Works related to drug delivery and disposition of drugs in humans were carried out at Department of Pharmacy, Kumamoto University Hospital. Topics related to drug delivery in humans include injections containing anticancer drugs for intra-arterial administration, lidocaine gels for dermal anesthesia, glucagon solution for nasal administration. Topics related to disposition of drugs in humans include clinical pharmacokinetic studies in infants and elderly and medical uses of adsorbents.

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Intraarterial infusion of 5-fluoro-2-deoxyuridine-C8 dissolved in a lymphographic agent in malignant liver tumors. A preliminary report

Cited by 28 publications

References 18 publications

Transcatheter oily chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: Results of a western comparative study in 60 patients

Transcatheter oily chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: Results of a western comparative study in 60 patients

In vitro Antitumor Activity, Intracellular Accumulation, and DNA Adduct Formation of cis‐[((1R, 2R)‐1,2‐Cyclohexanediamine‐N, N')bis(myristato)] Platinum (II) Suspended in Lipiodol

From Physical Pharmacy to Clinical Pharmacology

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