Intraarterial Concomitant Chemoradiation for Tongue Cancer: Analysis of 20 Patients

Abstract

Subjects were 20 patients with tongue cancer treated between April 1996 and December 2002 with intraarterial infusion of cisplatin (60-120mg/mm2) (and docetaxel 10-30mg/mm2) and intravenous infusion of sodium thiosulfate followed by 5-fluorouracil (5-FU) (800-1000mg/mm2) for 3 to 5 days. All patients underwent radiation (50-80 Gy). Ten had stage II, 4 stage III, and 6 stage IV A disease. Complete response at the primary site was achieved in 50% for T2, 67% for T3, and 0% for T4 lesions in those undergoing IA cisplatin followed by systemic 5-FU with concurrent radiation.Complete response at the primary site was achieved in all patients given IA cisplatin and docetaxel followed by systemic 5-FU with concurrent radiation. Disease-specific survival was 75% and overall survival 69% at 5 years. Side effects of treatment were tolerable, except for grade three radiomucositis in 70% of patients and grade three bone marrow depression in one treated with weekly LA chemotherapy.

Analysis of the outcome of concurrent neoadjuvant chemoradiotherapy with S-1 compared to super-selective intra-arterial infusion for oral squamous cell carcinoma

“…The response rate of primary lesions and the organ conservation rate have increased with the development of potent chemotherapeutic drugs and regimens for concomitant drug administration and advancements in administration methods, for example chemotherapy by super-selective intra-arterial infusion (8)(9)(10)(11)(12). According to the oral cancer treatment guidelines in Japan, platinum-based drugs, including CDDP, are widely used in chemotherapy as the standard, but S-1 is also used.…”

“…In particular, therapy employing super-selective intra-arterial infusion for head and neck cancers has been shown to contribute to organ preservation and an increase in the survival rate (6)(7)(8)(9)(10)(11)(12). However, a number of problems remain, for example, the technical difficulty of intra-arterial infusion, limitations due to the anatomical vascular distribution, local tissue necrosis, edema, swelling and pain (6)(7)(8).…”