Intraarterial Cisplatin and Caffeine With/Without Doxorubicin for Musculoskeletal High-Grade Spindle-Cell Sarcoma

Surgical Management of Malignant Soft Tissue Tumours in Patients Aged 65 Years or Older

“…The rate of dermatofibrosarcoma protuberance was exceedingly low, although recurrence among geriatric patients should also be avoided. After wide excision, including that of skin, muscle, tendon, vessel, and bone, reconstruction can be done using a prosthetic joint replacement, 14,15 an MC-flap for dead space, and functional repair using transfer or transplantation of the muscle with the nerve, [16][17][18][19][20][21][22][23][24][25] along with a vascular graft 26,27 and autobone graft or pasteurised bone graft. 28,29 The 5-year survival rate of the elderly with malignant soft tissue tumours in our series was 79.6%, which was higher than that reported in other studies.…”

Functional outcome in patients with osteosarcoma around the knee joint treated by minimised surgery

“…Caffeine can enhance the cytocidal effects of anticancer drugs safely through its deoxyribonucleic acid repairinhibiting effect [13]. We have demonstrated that caffeineassisted chemotherapy induced a high rate of complete response in patients with osteosarcoma [12].…”

Massive autoclaved allografts and autografts for limb salvage surgery A1-8 year follow-up of 23 patients

“…The mean age of the 23 patients was 37 (1247) years and the mean follow-up was 49 (14-98) months (Table 1). Pre-and postoperative chemotherapy (cisplatin (120 mg/m2), adriamycin (30 mg/m2 x 2) and caffeine (1500 mg/m2 x 3) was given to 11 patients with highgrade sarcomas (Tsuchiya et al 1994 ).…”