Intraarterial chemotherapy as the first-line therapy in penile cancer

Abstract

Background:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available.Methods:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used were methotrexate, mitomycin C, bleomycin, cisplatin, and 5-fluorouracil. Surgery was followed by the tumour responses.Results:An objective tumour response was noted in 10 of 12 patients (83%, 4 complete responders and 6 partial responders). In node-negative patients (n=7), the response rate was 100% (4 complete responders and 3 partial responders). Even in advanced penile squamous cell carcinoma with nodal invasion, a response rate of 60% could be achieved. Grade 2 anorexia was the most frequent chemotherapy-related toxicity and no toxic death was noted. Recurrence-free survival was significantly better in patients without lymph node invasion (log-rank test, P=0.041).Conclusions:Neoadjuvant intraarterial chemotherapy displayed excellent responses for penile squamous cell carcinoma. This therapy could effectively shrink the tumour burden or even achieve complete response before surgery. It could be used as first-line strategy for penile cancer treatment because of low toxicity.

Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma

“…Several prognostic factors have been established for PeCa patients, while regional inguinal lymph node involvement remains the most important predictor of an unfavorable prognosis 17 . Patients with locally advanced penile squamous cell carcinoma and lymph node metastasis are submitted to total or partial penile amputation, followed by primary chemotherapy or radiotherapy 18 . In a recent review, Burnett et al .…”

A Gigantic Anogenital Lesion: Buschke-Lowenstein Tumor

“…Chemoradiation has been recommended in cases when malignant transformation may occur [3]. Intra-arterial chemotherapy with agents such as methotrexate has also been successfully utilized in verrucous carcinoma of different parts of the body, including the anogenital region [5, 6]. This modality may be used as neoadjuvant therapy before surgical intervention and in certain cases may obviate the need for surgery [5, 6].…”

“…Intra-arterial chemotherapy with agents such as methotrexate has also been successfully utilized in verrucous carcinoma of different parts of the body, including the anogenital region [ 5 , 6 ]. This modality may be used as neoadjuvant therapy before surgical intervention and in certain cases may obviate the need for surgery [ 5 , 6 ]. Radiation therapy alone has generally been discouraged because of potential risk of transformation into anaplastic carcinoma [ 7 ].…”

Neoadjuvant chemotherapy for patients with locally advanced penile cancer

“…Several retrospective studies have currently reported the application of NAC for locally advanced penile cancers. 13 15 16 17 18 21 22 23 24 25 26 27 28 29 The efficacy and safety of NAC were assessed to achieve the most up-to-date evidence and explore the optimal chemotherapy regimen.…”