Intra-ventral pallidal glutamate antagonists block expression of morphine-induced place preference.

Dallimore, Jeanine E; Mickiewicz, Amanda L.; Napier, T. Celeste

doi:10.1037/0735-7044.120.5.1103

Cited by 33 publications

(35 citation statements)

References 84 publications

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“…In addition to its participation in food reinforcement, the VP contributes to drug reinforcement (88, 143, 157, 165). However, only a few studies have assessed the contribution of VP opioids to drug intake over the past decade.…”

Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

831

676

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The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechanisms whereby aberrant activation and modifications of the opioid system contribute to drug craving and relapse remain to be clarified. This review summarizes our present knowledge on brain sites where the endogenous opioid system controls hedonic responses and is modified in response to drugs of abuse in the rodent brain. We review 1) the latest data on the anatomy of the opioid system, 2) the consequences of local intracerebral pharmacological manipulation of the opioid system on reinforced behaviors, 3) the consequences of gene knockout on reinforced behaviors and drug dependence, and 4) the consequences of chronic exposure to drugs of abuse on expression levels of opioid system genes. Future studies will establish key molecular actors of the system and neural sites where opioid peptides and receptors contribute to the onset of addictive disorders. Combined with data from human and nonhuman primate (not reviewed here), research in this extremely active field has implications both for our understanding of the biology of addiction and for therapeutic interventions to treat the disorder.

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Section: Local Pharmacological Manipulation Of the Opioid Systemmentioning

confidence: 99%

Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

831

676

View full text Add to dashboard Cite

show abstract

“…Showing that these receptors are also necessary, behavioral sensitization induced by repeated systemic injections of morphine is blocked by intra-VP injections of the mu opioid antagonist CTOP (Johnson and Napier, 2000; Mickiewicz et al, 2008). Moreover, VP ionotropic glutamatergic receptors are necessary for the maintenance of behavioral sensitization previously induced by systemic injections of morphine, as maintenance is blocked by VP injections of the glutamate antagonists, CNQX and AP-5 (Dallimore et al, 2006). Glutamatergic adaptations to chronic exposure to opiates include an increase in VP mGlu5 receptor surface expression (Herrold et al, 2013).…”

Section: 0 Drugs Of Abuse; Influences On Vp Function and Behaviormentioning

confidence: 99%

“…Cocaine-induced CPP can be attenuated by VP mu opioid receptor antagonism, which creates conditioned place aversion (Skoubis and Maidment, 2003), or by 6-OHDA-induced lesions of VP (Gong et al, 1997b). Further, morphine-induced CPP can be blocked by intra-VP injections of the AMPA and NMDA glutamate receptor antagonists CNQX and AP-5 (Dallimore et al, 2006). Dopamine within the Acb and VP are also involved in psychostimulant-induced CPP, and dopamine concentrations within both regions correlate with CPP to cocaine conditioned place preference (Sellings and Clarke, 2003; Gong et al, 1997b).…”

Section: 0 Drugs Of Abuse; Influences On Vp Function and Behaviormentioning

confidence: 99%

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Root

Meléndez

Záborszky

et al. 2015

Progress in Neurobiology

Self Cite

295

362

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The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psychiatric disorders. This review is presented to help bridge the gap by providing a resource for current knowledge of VP anatomy, projection patterns and subregional circuits, and how this organization relates to the function of VP neurons and ultimately behavior. For example, ventromedial (VPvm) and dorsolateral (VPdl) VP subregions receive projections from nucleus accumbens shell and core, respectively. Inhibitory GABAergic neurons of the VPvm project to mediodorsal thalamus, lateral hypothalamus, and ventral tegmental area, and this VP subregion helps discriminate the appropriate conditions to acquire natural rewards or drugs of abuse, consume preferred foods, and perform working memory tasks. GABAergic neurons of the VPdl project to subthalamic nucleus and substantia nigra pars reticulata, and this VP subregion is modulated by, and is necessary for, drug-seeking behavior. Additional circuits arise from nonGABAergic neuronal phenotypes that are likely to excite rather than inhibit their targets. These subregional and neuronal phenotypic circuits place the VP in a unique position to process motivationally-relevant stimuli and coherent adaptive behaviors.

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“…see Dallimore et al . [5]). Administration of the 5-HT 2C receptor agonist MK 212 into either subregion reduced both horizontal and vertical activity.…”

Section: Resultsmentioning

confidence: 99%

“…Rats were bilaterally implanted with guide cannula (23 G, 5mm wide, 16mm long) overlying the ventral pallidum per our prior procedures [5]. Approximately 1 week after surgery, rats were habituated to motor activity monitoring chambers (automated using two stacked banks of photobeams; Accuscan Instruments Inc., Columbus, Ohio, USA) for 60 min before intraventral pallidal injections and motor testing.…”

Section: Methodsmentioning

confidence: 99%

Serotonin2C receptors in the ventral pallidum regulate motor function in rats

et al. 2013

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The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT2C receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT2C receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33–10 ng of the 5-HT2C receptor agonist MK 212 into the ventral pallidum of adult male Sprague–Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT2C receptors in the ventral pallidum.

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Intra-ventral pallidal glutamate antagonists block expression of morphine-induced place preference.

Cited by 33 publications

References 84 publications

Reward Processing by the Opioid System in the Brain

Reward Processing by the Opioid System in the Brain

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Serotonin2C receptors in the ventral pallidum regulate motor function in rats

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