Abstract:Objective: The present study investigates the predictive validity of intra-subject variability (ISV) for ADHD traits in a community-based sample and the stability of the relationship between ISV and fluid intelligence (gf) across the continuum of ADHD traits. Method: Age-residualized data from 426 participants (8–18 years, 6% ADHD) was used to investigate whether ex-Gaussian and DDM parameters derived from simple choice-reaction-time tasks can predict continuously assessed ADHD traits. Multiple-Group-Analyses … Show more
“…RT reflects speed of information processing, while SD of RT reflects consistency in processing speed ( Jensen, 1992 ), suggesting that alertness and sensory processing were inconsistent across trials after triple tSMS over the bilateral MAC. Also, SD of RT has been reported to be more sensitive than mean RT as a marker of cognitive impairment ( Klein et al, 2006 ; Schulz-Zhecheva et al, 2023 ). Moreover, Gonzalez-Rosa et al (2015) demonstrated that visual search RT was prolonged after tSMS over the occipital cortex only when the task was difficult.…”
BackgroundTranscranial static magnetic stimulation (tSMS) is a non-invasive brain stimulation technique that place a strong neodymium magnet on scalp to reduce cortical excitability. We have recently developed a new tSMS device with three magnets placed close to each other (triple tSMS) and confirmed that this new device can produce a stronger and broader static magnetic field than the conventional single tSMS. The aim of the present study was to investigate the effect of the conventional single tSMS as well as triple tSMS over the unilateral or bilateral motor association cortex (MAC) on simple and choice reaction time (SRT and CRT) task performance.MethodsThere were two experiments: one involved the conventional tSMS, and the other involved the triple tSMS. In both experiments, right-handed healthy participants received each of the following stimulations for 20 min on different days: tSMS over the unilateral (left) MAC, tSMS over the bilateral MAC, and sham stimulation. The center of the stimulation device was set at the premotor cortex. The participants performed SRT and CRT tasks before, immediately after, and 15 min after the stimulation (Pre, Post 0, and Post 15). We evaluated RT, standard deviation (SD) of RT, and accuracy (error rate). Simulation was also performed to determine the spatial distribution of magnetic field induced by tSMS over the bilateral MAC.ResultsThe spatial distribution of induced magnetic field was centered around the PMd for both tSMS systems, and the magnetic field reached multiple regions of the MAC as well as the sensorimotor cortices for triple tSMS. SD of CRT was significantly larger at Post 0 as compared to Pre when triple tSMS was applied to the bilateral MAC. No significant findings were noted for the other conditions or variables.DiscussionWe found that single tSMS over the unilateral or bilateral MAC did not affect performance of RT tasks, whereas triple tSMS over the bilateral MAC but not over the unilateral MAC increased variability of CRT. Our finding suggests that RT task performance can be modulated using triple tSMS.
“…RT reflects speed of information processing, while SD of RT reflects consistency in processing speed ( Jensen, 1992 ), suggesting that alertness and sensory processing were inconsistent across trials after triple tSMS over the bilateral MAC. Also, SD of RT has been reported to be more sensitive than mean RT as a marker of cognitive impairment ( Klein et al, 2006 ; Schulz-Zhecheva et al, 2023 ). Moreover, Gonzalez-Rosa et al (2015) demonstrated that visual search RT was prolonged after tSMS over the occipital cortex only when the task was difficult.…”
BackgroundTranscranial static magnetic stimulation (tSMS) is a non-invasive brain stimulation technique that place a strong neodymium magnet on scalp to reduce cortical excitability. We have recently developed a new tSMS device with three magnets placed close to each other (triple tSMS) and confirmed that this new device can produce a stronger and broader static magnetic field than the conventional single tSMS. The aim of the present study was to investigate the effect of the conventional single tSMS as well as triple tSMS over the unilateral or bilateral motor association cortex (MAC) on simple and choice reaction time (SRT and CRT) task performance.MethodsThere were two experiments: one involved the conventional tSMS, and the other involved the triple tSMS. In both experiments, right-handed healthy participants received each of the following stimulations for 20 min on different days: tSMS over the unilateral (left) MAC, tSMS over the bilateral MAC, and sham stimulation. The center of the stimulation device was set at the premotor cortex. The participants performed SRT and CRT tasks before, immediately after, and 15 min after the stimulation (Pre, Post 0, and Post 15). We evaluated RT, standard deviation (SD) of RT, and accuracy (error rate). Simulation was also performed to determine the spatial distribution of magnetic field induced by tSMS over the bilateral MAC.ResultsThe spatial distribution of induced magnetic field was centered around the PMd for both tSMS systems, and the magnetic field reached multiple regions of the MAC as well as the sensorimotor cortices for triple tSMS. SD of CRT was significantly larger at Post 0 as compared to Pre when triple tSMS was applied to the bilateral MAC. No significant findings were noted for the other conditions or variables.DiscussionWe found that single tSMS over the unilateral or bilateral MAC did not affect performance of RT tasks, whereas triple tSMS over the bilateral MAC but not over the unilateral MAC increased variability of CRT. Our finding suggests that RT task performance can be modulated using triple tSMS.
“…The intraindividual variability in individuals with ADHD has been widely analyzed with or without the ex-Gaussian distributions of RT (Hohle, 1965; Ratcliff, 1979), which has proven to be a valuable tool in characterizing differences in RT between individuals with ADHD and controls (Bella-Fernández et al, 2023; Bluschke et al, 2021; Buzy et al, 2009; Castellanos et al, 2009; Flehmig et al, 2007; Fredriksen et al, 2021; Galloway-Long et al, 2022; Gmehlin et al, 2014; Gu et al, 2013; Guo et al, 2022; Hervey et al, 2006; Horowitz et al, 2020; Kofler et al, 2013; Kuntsi & Klein, 2012; Lin et al, 2015; Leth-Steensen et al, 2000; Schmid et al, 2020; Schulz-Zhecheva et al, 2023; Vainieri et al, 2022; Vaurio et al, 2009). Computational models using ex-Gaussian distributions used in conjunction with clinical assessments refine our understanding of cognitive concepts as: slow processing speed, and inhibition failures, which are commonly found in Individuals with ADHD (Ging-Jehli et al, 2021; Nikolas et al, 2019).…”
Objective: Interindividual similarity refers to how similarly individuals respond when receiving the same stimulus or intervention. In this study, we aimed to examine interindividual similarity in adults with ADHD. Method: We used the cosine similarity index of ex-Gaussian reaction time (RT) vectors of mu, sigma, and tau parameters during a Stroop task. Results: Our results demonstrate that the ADHD group exhibits a reduced interindividual similarity index in their ex-Gaussian RT vectors for congruent stimuli compared to the healthy control group. Importantly, we did not find significant differences in the interindividual similarity index to incongruent stimuli between both groups, thus suggesting that this reduced index was selective for congruent stimuli. Conclusion: Our findings highlight that ADHD adults exhibit more significant interindividual differences in cognitive functioning when processing congruent stimuli than healthy controls. These results provide new insights into the selective mechanisms underlying ADHD and may contribute to developing new targeted interventions for this disorder.
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