Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats

Pourrahimi, Ali Mohammad; Abbasnejad, Mehdi; Esmaeili‐Mahani, Saeed; Kooshki, Razieh; Raoof, Maryam

doi:10.1016/j.npep.2018.12.001

Cited by 14 publications

(6 citation statements)

References 81 publications

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“…5H). Consistent with this notion, activation of Hcrtr1 (Pourrahimi et al, 2019) and Crhr1 (Sergio Tde et al, 2014) expressing clusters in PAG has been reported to induce both heightened anxiety and antinociception. Additionally, Hcrtr1/2 (Annerbrink et al, 2011; Gottschalk et al, 2019), Crhr1 (Weber et al, 2016), and Adra1a (Zhang et al, 2017) polymorphisms are strongly associated with human panic disorders and targets for clinical therapy (Johnson et al, 2010; Lohoff et al, 2013), suggesting cells expressing these genes may be of critical importance to the PAG’s role in anxiety (Fanselow, 1991).…”

Section: Resultsmentioning

confidence: 74%

Three-dimensional Interrogation of Cell Types and Instinctive Behavior in the Periaqueductal Gray

Vaughn

Eichhorn

Zhuang

et al. 2022

Preprint

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The periaqueductal gray (PAG) is a critical midbrain hub that relays information from the forebrain to motor and autonomic brainstem centers to orchestrate instinctive behaviors. The current organization of the PAG into four main radial columns lacks the resolution needed to account for the vast range of PAG functions. Using spatially resolved single-cell transcriptomic measurements, we uncovered widespread transcriptional heterogeneity in the PAG with >100 excitatory and inhibitory neuronal populations, which further assemble into 19 spatial metaclusters. We explored the transcriptional and spatial logic of PAG function during instinctive behaviors and demonstrated the regional recruitment of cell types for distinct behaviors. Unexpectedly, certain behaviors trigger differential spatial activation patterns within given cell types, illustrating the complexity of PAG molecular and functional 3D organization. The newly uncovered spatial motifs and high precision cellular map of instinctive behavior in the PAG open new avenues for a mechanistic understanding of PAG function.

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Section: Resultsmentioning

confidence: 74%

Three-dimensional Interrogation of Cell Types and Instinctive Behavior in the Periaqueductal Gray

Vaughn

Eichhorn

Zhuang

et al. 2022

Preprint

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“…104 Accumulating evidence also suggests that during stress, hypothalamic neurons likely release orexins in the PAG to induce analgesia. [105][106][107] Human studies corroborate PAG involvement in migraine pathobiology. Brain structural and resting state functional connectivity (rsFC) was decreased in patients with episodic migraine compared with healthy controls.…”

Section: Brainstem and Diencephalic Mechanisms Of Headache Brainstem ...mentioning

confidence: 71%

Anatomy and Physiology of Headache

Harriott

Orlova

2022

Semin Neurol

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Headache disorders can produce recurrent, incapacitating pain. Migraine and cluster headache are notable for their ability to produce significant disability. The anatomy and physiology of headache disorders is fundamental to evolving treatment approaches and research priorities. Key concepts in headache mechanisms include activation and sensitization of trigeminovascular, brainstem, thalamic, and hypothalamic neurons; modulation of cortical brain regions; and activation of descending pain circuits. This review will examine the relevant anatomy of the trigeminal, brainstem, subcortical, and cortical brain regions and concepts related to the pathophysiology of migraine and cluster headache disorders.

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“…It has been reported that carbachol microinjections into the hippocampus reduced formalin‐induced orofacial nociception in acute orofacial pain (Haghparast et al, 2018). Moreover, Pourrahimi et al (2019) evidenced a significant increase in c‐fos expression in the vlPAG following intradental capsaicin. This effect was attenuated by pretreatment with orexin 1 and cannabinoid 1 receptor antagonists injected in the same area (Pourrahimi et al, 2019).…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, Pourrahimi et al (2019) evidenced a significant increase in c‐fos expression in the vlPAG following intradental capsaicin. This effect was attenuated by pretreatment with orexin 1 and cannabinoid 1 receptor antagonists injected in the same area (Pourrahimi et al, 2019). It is known that vlPAG plays a crucial role in pain modulation, including pain evoked by stimulation of the mandible (Kupers et al, 2004) and facial skin (Mainero et al, 2007).…”

Section: Discussionmentioning

confidence: 97%

Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures

Nascimento

Paula

Gerlach

et al. 2021

Journal Cellular Physiology

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Temporomandibular disorder (TMD) is characterized by acute or chronic orofacial pain, which can be associated with inflammatory processes in the temporomandibular joint (TMJ) and emotional disorders. Peripheral and central sensitization in painful orofacial processes is common, and it can be triggered by peripheral inflammatory challenge with consequent neuroinflammation phenomena. Such neuroinflammation comes from inflammatory products from supportive cells, blood-brain barrier, and extracellular matrix. Here, we evaluated the possible recruitment of limbic structures for modified matrix metalloproteinases (MMPs) expression and activity during temporomandibular inflammation-induced orofacial persistent pain. The inflammatory process in TMJs of rats was induced by Freund's Complete Adjuvant (CFA) administration.The activity and expression of MMPs-2 and 9 were assessed by in situ zymography and conventional zymography, respectively. A glial colocalization with the MMPs was performed using immunofluorescence. The results evidenced both short-and long-term alterations on MMP-2 and -9 expression in the limbic structures following CFA-induced temporomandibular inflammation. The gelatinolytic activity was increased in the central amygdala, hippocampus, hypothalamus, ventrolateral periaqueductal gray (vlPAG), superior colliculus, and inferior colliculus. Finally, an increase of colocalization of MMP-2/GFAP and MMP-9/GFAP in CFA-induced inflammation groups was observed when compared with saline groups in the central amygdala and vlPAG. It is possible to suggest that glial activation is partly responsible for the production of gelatinases in the persistent orofacial pain, and it is involved in the initiation and maintenance of this process, indicating that inhibition of MMPs might be pursued as a potential new therapeutic target for TMD.

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Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats

Cited by 14 publications

References 81 publications

Three-dimensional Interrogation of Cell Types and Instinctive Behavior in the Periaqueductal Gray

Three-dimensional Interrogation of Cell Types and Instinctive Behavior in the Periaqueductal Gray

Anatomy and Physiology of Headache

Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures

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