Intra-paragigantocellularis lateralis injection of orexin-A has an antinociceptive effect on hot plate and formalin tests in rat

Erami, Elaheh; Azhdari-Zarmehri, Hassan; Ghasemi-Dashkhasan, Elmira; Esmaeili, Mohammad; Semnanian, Saeed

doi:10.1016/j.brainres.2012.08.013

Cited by 24 publications

(15 citation statements)

References 35 publications

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“…Neuropeptide Quantification It has been shown that neurotensin is implicated in analgesia via its actions within central and peripheral pain modulatory circuits, 23 oxytocin plays an antinociceptive role in the central nervous system, 2 and orexin is involved in nociceptive sensory processes. 3,24 Neuropeptides were determined by a Luminex (Luminex Corporation, Austin, TX) assay (Milliplex; EMD Millipore Corporation, Billerica, MA). This kit allows the simultaneous quantification of neurotensin, orexin A, and oxytocin (Milliplex HNP-35K; EMD Millipore Corporation).…”

Section: Outcome Measuresmentioning

confidence: 99%

Changes in Biochemical Markers of Pain Perception and Stress Response After Spinal Manipulation

Plaza-Manzano

Molina²,

Lomas‐Vega³

et al. 2014

J Orthop Sports Phys Ther

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Section: Outcome Measuresmentioning

confidence: 99%

Changes in Biochemical Markers of Pain Perception and Stress Response After Spinal Manipulation

Plaza-Manzano

Molina²,

Lomas‐Vega³

et al. 2014

J Orthop Sports Phys Ther

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“…The formalin test as an acute inflammatory pain model is a commonly used (Sofiabadi et al, 2014; Azhdari-Zarmehri, Semnanian, & Fathollahi, 2014; Azhdari-Zarmehri, Esmaeili, Sofiabadi, & Haghdoost-Yazdi, 2013; Heidari-Oranjaghi, Azhdari-Zarmehri, Erami, & Haghparast, 2012; Erami, Azhdari-Zarmehri, Ghasemi-Dashkhasan, Esmaeili, & Semnanian, 2012). When compared to other nociceptive stimuli (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Following this period, the interphase begins, which is characterized by attenuation of nociceptive behaviors. The second phase (15–90 min) begins approximately 15 minutes after the injection and reflects ongoing peripheral activity and central sensitization (Coderre & Melzack, 1992; Coderre, Vaccarino & Melzack,1990; Dubuisson & Dennis, 1978; Erami, Azhdari-Zarmehri, Ghasemi-Dashkhasan, Esmaeili & Semnanian, 2012; Gheibi, Saroukhani & Azhdari-Zarmehri, 2013). Furthermore, biphasic painful behaviors (Clavelou et al, 1995; Coderre, & Melzack, 1992) as well as electrophysiological responses from dorsal horn neurons of the spinal cord, can be recorded for longer than one hour after formalin injection (Heidari-Oranjaghi, Azhdari-Zarmehri, Erami & Haghparast, 2012; Hunskaar, Berge & Hole, 1986).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

Erami

Azhdari-Zarmehri

Imoto

et al. 2017

BCN

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Introduction:Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin.Methods:In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into either glabrous skin (plantar surface) of the hind paw or hairy skin of the hind limb in adult rats.Results:A typical biphasic nociceptive response was seen after formalin injection into the plantar surface of the hind paw. A brief interphase separates the first and second phases where nociceptive behaviors were barely spotted. However, following subcutaneous injection into the hairy skin nociceptive behaviors were only seen after 10 minutes of formalin injection, which correlates in time with the second phase of the formalin response. First phase nociceptive behaviors were never seen with hairy skin injection, even following multiple injections of formalin.Conclusion:These data suggest that nociceptive behaviors and spinal responses induced by formalin injections to glabrous and hairy skin areas are different, and that the first and second phases may be mediated through different noxious afferent fibers.

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“…These effects are mediated by OXR1 in spinal cord [25]. OX-A-induced antinociception in both formalin and hot plate test mainly mediated through OXR1 in paragigantocellularis lateralis nuclei [26]. Other study performed in mice, OX-A and B showed antinociceptive effects in all four types of assays for thermal, mechanical, chemical nociceptions and nociceptin-induced behavioral responses when administered ICV or IT, whereas the SC administration was ineffective [27].…”

Section: Discussionmentioning

confidence: 80%

The Effects of Orexin A and B on Two Forms of Immobility Responses and on Analgesia

Miranda-Páez

Vázquez-León

Martı́nez-Mota

et al. 2014

Advances in Neuroimmune Biology

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The orexins are important for the regulation of several behavioral patterns, including feeding, arousal state, drug seeking, voluntary locomotion and nociception.Two orexins (A and B), and two different orexin receptors are known, which have differential distribution. This suggests that orexins and distinct orexin receptors may regulate specific behaviors such as immobility associated analgesia. The periaqueductal gray (PAG) is considered to be the main center for the analgesia and immobility responses in the central nervous system (CNS).Here we compared the effect of orexin A (OX-A) and orexin B (OX-B) after intracerebroventricular (ICV) or the ventrolateral periaqueductal gray (vl-PAG) injection. Two forms of immobility responses were studied: cataleptic (CAT) and tonic (TI) responses. The latter was associated with analgesia as part of a defensive response in several species.We observed that OX-A was more effective than OX-B to reduce CAT; OX-B was slightly more potent than OX-A to decrease TI and neither orexins were able to induce analgesia when orexins were injected ICV.After microinjection into vl-PAG CAT was unaffected by orexins and both orexins significantly decrease TI. Microinjected OX-A did not show analgesic activity but OX-B produced significant analgesic effect assessed by tail-flick test.

show abstract

Intra-paragigantocellularis lateralis injection of orexin-A has an antinociceptive effect on hot plate and formalin tests in rat

Cited by 24 publications

References 35 publications

Changes in Biochemical Markers of Pain Perception and Stress Response After Spinal Manipulation

Changes in Biochemical Markers of Pain Perception and Stress Response After Spinal Manipulation

Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats

The Effects of Orexin A and B on Two Forms of Immobility Responses and on Analgesia

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