Intra-osseous tophaceous gout of a bipartite patella mimicking aggressive bone tumour

Corpus-Zuñiga, Fidelis Marie; Muramatsu, Keiichi; Rayel, Ma Felma; Tani, Yasuhiro; Seto, Tetsuya

doi:10.1080/24725625.2020.1861743

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…The histological findings in PGDD and gout are similar and difficult to differentiate between them using HE staining. There are reports of cases of intraosseous tophaceous gout with normal serum uric acid levels, leading to confusion 15,16 . As GHA staining can detect the ester bonds of phosphoglycerides under the light microscope by variants of the hydroxamic acid reaction, this staining is considered a useful tool to distinguish PGDD from other crystal forming conditions 17,18 .…”

Section: Discussionmentioning

confidence: 99%

Phosphoglyceride Crystal Deposition Disease of the Scapula

Hori¹,

Nagano²,

Miyazaki

et al. 2023

JBJS Case Connector

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Case:A 76-year-old woman presented with a 2-month history of right shoulder pain with no apparent cause. Radiography revealed an ill-defined osteolytic lesion in the right scapular spine with a pathological fracture. Malignant bone tumor was suspected, and a biopsy was performed. Pathological examination with gold hydroxamic acid staining revealed phosphoglyceride crystal deposition. Lesion curettage was performed, and her symptoms improved. No recurrence was observed at the 3-year postoperative follow-up.Conclusion:Phosphoglyceride crystal deposition in the bone is an extremely rare disease. The gold hydroxamic acid staining method might be useful for the diagnosis of this condition.

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Section: Discussionmentioning

confidence: 99%

Phosphoglyceride Crystal Deposition Disease of the Scapula

Hori¹,

Nagano²,

Miyazaki

et al. 2023

JBJS Case Connector

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“…In addition, the cases of tophaceous fractures described in the literature were predominantly located in the patella, femoral neck and hip [ 5 , [10] , [11] , [12] ].…”

Section: Discussionmentioning

confidence: 99%

“…Another key aspect is the importance of careful differential diagnosis between gouty and neoplastic processes. While high uric acid levels in association with clear radiological findings may avoid biopsy, it must be considered necessary in case of low uric acid levels [ 10 , 12 , 13 ]. The differential diagnosis is essential because the treatment of secondary bone neoplastic lesions and myeloma is obviously different from that of gouty lesions.…”

Section: Discussionmentioning

confidence: 99%

Case report of a tibial fracture in a patient suffering from gout: An atypical site, the importance of differential diagnosis

Calvi

Gnesutta

Zabetta

et al. 2022

Radiology Case Reports

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We present the case of a 60-year-old man with a history of severe tophaceous gout with polyarticular involvement who came to the emergency room due to direct trauma to the right forearm and knee. The knee X-ray and CT scan showed a lateral tibial plateau fracture characterized by the presence of a lytic bone lesion. The presence of a solid neoplasm was ruled out and a CT-guided biopsy was performed. Histological evaluation revealed findings typical for an advanced intraosseous gout. As there was no significant risk of progression of the lytic lesion, the fracture site was treated conservatively. This case is unique in the literature in terms of location and should be considered as an atypical site of intraosseous gout. Proper differentiation of a pathological fracture on an intraosseous gout location from a neoplastic lesion is essential to choose the correct therapy.

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Intra-osseous tophaceous gout of a bipartite patella mimicking aggressive bone tumour

Cited by 2 publications

References 14 publications

Phosphoglyceride Crystal Deposition Disease of the Scapula

Phosphoglyceride Crystal Deposition Disease of the Scapula

Case report of a tibial fracture in a patient suffering from gout: An atypical site, the importance of differential diagnosis

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