If there is one thing that the COVID-19 pandemic has taught us, it is that we live in an interdependent world. The pandemic has brought into stark relief three forms of interdependence. First, we see more clearly than ever the interrelationships between human and non-human networks, with human invasion of animal habitats and people's connectivity via global transportation systems creating the perfect conditions for pandemics. Second, the chains of interdependence linking human and non-human networks are both complex and tightly coupled, such that the employment of an individual or the performance of a company on one continent are not independent of the wildlife that people on the other side of the world come in contact with. Third, we have learned that the response to pandemics hinges on the management of interdependent tasks performed by organizations, industries, nation-states and international institutions, and the resources each deploy over time toward the execution of those tasks; lacking a coordinated response to these interdependencies, global supply chains are disrupted, delaying the production and distribution of vital supplies to communities that need them, and slowing-sometimes fatally-how businesses large and small adapt to shifting market demand and the resources required to meet it. Although interdependence has long been an object of inquiry in both organizational theory-for example, with research on high-reliability organizations (e.g., Perrow, 1984)-and strategy-with work on firms as ecosystems of interdependent choices (e.g., Siggelkow, 2011)-the exceptional scope and intricacy of social and economic reverberations from pandemics recast interdependence as a newly central construct in management studies. Management scholars must, therefore, reassess the assumptions, theories, methods they draw from to address the unique challenges presented by ubiquitous and