Intra-orbitofrontal cortex injection of haloperidol removes the beneficial effect of methylphenidate on reversal learning of spontaneously hypertensive rats in an attentional set-shifting task

Cheng, Jen-Tang; Li, Jay-Shake

doi:10.1016/j.bbr.2012.11.006

Cited by 16 publications

(11 citation statements)

References 39 publications

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“…These discrepancies might be explained by the sensitivity of the different behavioral tests and by the use of Wistar rats as controls in the present study while WKY are typically the normotensive-control group for SHR. However, we, and others, observed a reduced level of locomotor activity and investigatory behavior in WKY rats compared to Wistar rats (Hård et al, 1985; Paré, 2000; Li and Huang, 2006; Cheng and Li, 2013), which makes them poor behavioral controls when compared to Wistars (Hernandez et al, 2003; Kantak et al, 2008; Cheng and Li, 2013). Arguably, there is no perfect control for the SHR in terms of behavior and with respect to the brain atrophy that is selectively observed in this strain.…”

Section: Discussionmentioning

confidence: 58%

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests

López-Gil

Amat-Roldán²,

Tudela

et al. 2014

Front. Aging Neurosci.

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The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive function. We examined the feasibility of early diagnostic magnetic resonance imaging (MRI) to predict cognitive impairment before onset in an animal model of chronic hypertension: Spontaneously Hypertensive Rats. Cognitive performance was tested in an operant conditioning paradigm that evaluated learning, memory, and behavioral flexibility skills. Behavioral tests were coupled with longitudinal diffusion weighted imaging acquired with 126 diffusion gradient directions and 0.3 mm3 isometric resolution at 10, 14, 18, 22, 26, and 40 weeks after birth. Diffusion weighted imaging was analyzed in two different ways, by regional characterization of diffusion tensor imaging (DTI) indices, and by assessing changes in structural brain network organization based on Q-Ball tractography. Already at the first evaluated times, DTI scalar maps revealed significant differences in many regions, suggesting loss of integrity in white and gray matter of spontaneously hypertensive rats when compared to normotensive control rats. In addition, graph theory analysis of the structural brain network demonstrated a significant decrease of hierarchical modularity, global and local efficacy, with predictive value as shown by regional three-fold cross validation study. Moreover, these decreases were significantly correlated with the behavioral performance deficits observed at subsequent time points, suggesting that the diffusion weighted imaging and connectivity studies can unravel neuroimaging alterations even overt signs of cognitive impairment become apparent.

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Section: Discussionmentioning

confidence: 58%

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests

López-Gil

Amat-Roldán²,

Tudela

et al. 2014

Front. Aging Neurosci.

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“…We originally chose four exploratory trials in Birrell and Brown (2000) because, whilst the rat was equally likely to dig in the unbaited bowl, they would have the opportunity to obtain a reward from each of the two baited bowls in each of the choice chambers twice (see section 4.5.1 above). The majority of publications use four exploratory trials (Brooks et al, 2012;Cain et al, 2011;Cheng and Li, 2013;McCoy et al, 2007;Nikiforuk et al, 2010), although some do not report whether they have any (Lapiz and Morilak, 2006), and some use fewer (Broberg et al, 2008;Goetghebeur and Dias, 2009). Some studies deviate slightly from this, either by not including exploratory trials in the TTC (Hatcher et al, 2005;Izquierdo et al, 2010;Nikiforuk et al, 2010), or by training to ten consecutively correct trials, but using six as the criterion during testing (Redrobe et al, 2012).…”

Section: Learning Criterionmentioning

confidence: 99%

Assessment of intradimensional/extradimensional attentional set-shifting in rats

Tait

Bowman

Neuwirth

et al. 2018

Neuroscience & Biobehavioral Reviews

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The rat intradimensional/extradimensional (ID/ED) task, first described by Birrell and Brown 18 years ago, has become the predominant means by which attentional set-shifting is investigated in rodents: the use of rats in the task has been described in over 135 publications by researchers from nearly 90 universities and pharmaceutical companies. There is variation in the protocols used by different groups, including differences in apparatus, stimuli (both stimulus dimensions and exemplars within), and also the methodology. Nevertheless, most of these variations seem to be of little consequence: there is remarkable similarity in the profile of published data, with consistency of learning rates and in the size and reliability of the set-shifting and reversal 'costs'. However, we suspect that there may be inconsistent data that is unpublished or perhaps 'failed experiments' that may have been caused by unintended deviations from effective protocols. The purpose of this review is to describe our approach and the rationale behind certain aspects of the protocol, including common pitfalls that are encountered when establishing an effective local protocol.

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“…Administration of methylphenidate in rodents does not affect reversal learning (Seu and Jentsch, 2009; Cheng and Li, 2013), although the latter authors observed beneficial effects in animals with reversal learning impairments (spontaneously hypertensive rats). Effects of amphetamine and methamphetamine on reversal learning have been variable, but possibly dose-dependent: high doses (5 mg/kg) impair reversal learning (Ridley et al, 1981; Arushanian and Baturin, 1982; Idris et al, 2005; Cheng et al, 2007; White et al, 2009; Izquierdo et al, 2010; Kosheleff et al, 2012; Talpos et al, 2012), while intermediate doses 1–2 mg/kg show no effect or improved learning (Wilpizeski and Hamilton, 1964; Kulig and Calhoun, 1972; Mead, 1974; Weiner and Feldon, 1986; Weiner et al, 1986; Daberkow et al, 2008; Pastuzyn et al, 2012; Soto et al, 2012) and low doses again impair reversal performance (Ridley et al, 1981; Idris et al, 2005).…”

Section: Pharmacological Manipulations In Animalsmentioning

confidence: 99%

“…However, given the multiple and differential effects of psychostimulants on monoamine release in prefrontal and striatal regions it is often difficult to conclude whether these effects depend on increased DA release. Yet, for methylphenidate Cheng and Li (2013) showed that the beneficial effect were blocked by local injections with haloperidol in the OFC.…”

Section: Pharmacological Manipulations In Animalsmentioning

confidence: 99%

Dopaminergic control of cognitive flexibility in humans and animals

2013

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Striatal dopamine (DA) is thought to code for learned associations between cues and reinforcers and to mediate approach behavior toward a reward. Less is known about the contribution of DA to cognitive flexibility—the ability to adapt behavior in response to changes in the environment. Altered reward processing and impairments in cognitive flexibility are observed in psychiatric disorders such as obsessive compulsive disorder (OCD). Patients with this disorder show a disruption of functioning in the frontostriatal circuit and alterations in DA signaling. In this review we summarize findings from animal and human studies that have investigated the involvement of striatal DA in cognitive flexibility. These findings may provide a better understanding of the role of dopaminergic dysfunction in cognitive inflexibility in psychiatric disorders, such as OCD.

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Intra-orbitofrontal cortex injection of haloperidol removes the beneficial effect of methylphenidate on reversal learning of spontaneously hypertensive rats in an attentional set-shifting task

Cited by 16 publications

References 39 publications

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests

Assessment of intradimensional/extradimensional attentional set-shifting in rats

Dopaminergic control of cognitive flexibility in humans and animals

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