Intra-oral Acantholytic Squamous Cell Carcinoma: 55 Cases. Is this Variant more Aggressive?

Acantholytic Squamous Cell Carcinoma Mimicking Angiosarcoma in the Oral Cavity - A Case Report and Literature Review

“…Hence, it is difficult to distinguish the two based on histology only and requires the need for immunohistochemistry for confirming diagnosis. In Figure 1 [6,7] we can see and compare how closely both mimic each other in histology. Other characteristics on H&E staining that can be seen are neoplastic cells, hyperchromatic nuclei, eosinophilic cytoplasm, atypical eiptheloid cells and keratin pearls, like what the biopsy fragments in this case report revealed.…”

Oral Acantholytic Squamous Cell Carcinoma: A Rare Case of Mandibular Alveolar Ulceration

“…It is also known as adenomatoid squamous cell carcinoma (SCC) or adenoacanthoma. It is distinguished by a characteristic SCC pattern, as well as the presence of dyskeratotic cells, pseudo-glandular structures, and significant acantholysis surrounding islands of parts of the tumors [ 1 ]. Such a breakdown of cell adherence, known as acantholysis, occurs as a result of desmosomal proteins being absent.…”

“…Intraoral ASCCs are believed to be more aggressive, potentially leading to a poor prognosis, necessitating a multidisciplinary treatment approach [ 3 ]. Less than 60 instances of ASCC have been documented in global literature so far [ 1 , 4 ]. This case report presents a rare case of ASCC in the oral mucosa without skin adnexal structures.…”