Intra-operative Touch Preparation Cytology; Does It Have a Role in Re-excision Lumpectomy?

Valdes, Edna K.; Boolbol, Susan K.; Cohen, J; Feldman, Sheldon

doi:10.1245/s10434-006-9263-x

Cited by 70 publications

(55 citation statements)

References 29 publications

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“…Ultrasound can be used with good results as well [19]. Imprint cytology of the surfaces of the specimen is also promising [20,21]. Systematic cavity shaving also reduces the postoperative finding of close margins and re-excision rates [22].…”

Section: What Is a Free Margin?mentioning

confidence: 99%

Margin status after breast‐conserving treatment of breast cancer: How much free margin is enough?

Smitten

2008

Journal of Surgical Oncology

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In breast conserving surgery the margins of the specimen have to be tumor free. There is no universal agreement on the width of the tumor free margin. The width has some impact on recurrence rate, and at least 5 mm seems to be preferred and this is especially important in extensive intraductal component. In ductal cancer in situ the free margin should be at least 5 mm, preferably 10 mm. Oncoplastic surgery is beneficial for reaching adequate margins.

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Section: What Is a Free Margin?mentioning

confidence: 99%

Margin status after breast‐conserving treatment of breast cancer: How much free margin is enough?

Smitten

2008

Journal of Surgical Oncology

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“…Therefore, defining cancer margins intraoperatively is an important step for lowering the re-excision rate. Alternative pathology approaches such as frozen section (FS) pathology (9) and Touch Prep (TP) cytology (10) have been proposed. However, performance limitations (11) have prevented mainstream adoption of such methods.…”

Section: Introductionmentioning

confidence: 99%

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer

et al. 2014

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Intraoperative delineation of breast cancer is a significant problem in surgical oncology. A reliable method for demarcation of malignant breast tissue during surgery would reduce the re-excision rate due to positive margins. We present a novel method of identifying breast cancer margins using combined dye-enhanced wide-field fluorescence polarization imaging for en face cancer margins and polarization-sensitive (PS) optical coherence tomography (OCT) for cross-sectional evaluation. Tumor specimens were collected following breast surgery, stained with methylene blue, and imaged. Wide-field fluorescence polarization images were excited at 640 nm and registered between 660 and 750 nm. Standard and PS OCT images were acquired using a commercial 1,310-nm swept-source system. The imaging results were validated against histopathology. Statistically significant higher fluorescence polarization of cancer as compared with both normal and fibrocystic tumor tissue was measured in all the samples. Fluorescence polarization delineated lateral breast cancer margins with contrast superior to that provided by OCT. However, OCT complemented fluorescence polarization imaging by facilitating cross-sectional inspection of tissue. PS OCT yielded higher contrast between cancer and connective tissue, as compared with standard OCT. Combined PS OCT and fluorescence polarization imaging shows promise for intraoperative delineation of breast cancer. Cancer Res; 74(17); 4685-93. Ó2014 AACR.

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“…Frozen section provides poor results due to difficulties sectioning adipose tissue, and adds 25-35 minutes to operating room time [14]. Touch prep cytology provides rapid assessment, but is limited to evaluating cells on the immediate surface of the tissue [15].…”

Section: Introductionmentioning

confidence: 99%

Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

South¹,

Chaney²,

Marjanović³

et al. 2014

Biomed. Opt. Express

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Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility of using PS-OCT to supplement structural OCT as a possible method for intraoperative tumor margin evaluation. References and links 1. American Cancer Society, Breast Cancer Facts & Figs. 2013 (American Cancer Society, Atlanta, GA, 2013. 2. B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J.-H. Jeong, and N. Wolmark, "Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer," N. Engl. J. Med. 347(16), 1233-1241 (2002). 3. U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, "Twentyyear follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer," N. Engl. J. Med. 347(16), 1227-1232 (2002). 4. P. Ananthakrishnan, F. L. Balci, and J. P. Crowe, "Optimizing surgical margins in breast conservation," Int. J. Surg. Oncol. 2012, 585670 (2012 J. Keely, "Aligned collagen is a prognostic signature for survival in human breast carcinoma," Am. ©2014 Optical Society of America

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Intra-operative Touch Preparation Cytology; Does It Have a Role in Re-excision Lumpectomy?

Cited by 70 publications

References 29 publications

Margin status after breast‐conserving treatment of breast cancer: How much free margin is enough?

Margin status after breast‐conserving treatment of breast cancer: How much free margin is enough?

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer

Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

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