Intra-Operative Irradiation in Abdominal and Cerebral Tumours

Abe, Mitsuyuki; Fukuda, Masahiro; Yamano, K.; Matsuda, Shinya; Handa, Hajime

doi:10.3109/02841867109130786

Cited by 56 publications

(14 citation statements)

References 3 publications

(2 reference statements)

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“…A partial topographic miss of the target could be a reason for local recurrence after boost therapy [29]. Linacbased IORT with high-energy electrons for breast cancer was initially introduced by Dubois et al, Merrick et al and Dobelbower et al [10,11,20], though this technique originated at the University of Kyoto in Japan by Abe et al [1][2][3][4]. Abe et al were the first to use IORT for treatment of advanced abdominal and cerebral tumors.…”

Section: Introductionmentioning

confidence: 99%

Local Recurrence Rates in Breast Cancer Patients Treated with Intraoperative Electron-Boost Radiotherapy Versus Postoperative External-Beam Electron-Boost Irradiation

Reitsamer

Peintinger²,

Kopp

et al. 2004

Strahlenther Onkol

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Section: Introductionmentioning

confidence: 99%

Local Recurrence Rates in Breast Cancer Patients Treated with Intraoperative Electron-Boost Radiotherapy Versus Postoperative External-Beam Electron-Boost Irradiation

Reitsamer

Peintinger²,

Kopp

et al. 2004

Strahlenther Onkol

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“…The modern approach to IORT began with studies by Abe at the University of Kyoto in the early 1960s [1,4,5]. Their approach to overcoming the limitations of surgery and EBRT in advanced abdominal tumours was to combine surgical excision of the tumour when possible, followed immediately by a single massive dose (25-30 Gy) of radiation during the operation.…”

Section: The Japanese Experiencementioning

confidence: 99%

Intraoperative radiation therapy

Calvo

Meiriño

Orecchia

2006

Critical Reviews in Oncology/Hematology

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“…Intraoperative radiotherapy (IORT) was developed by Abe et al in 1964 and used mainly for the treatment of carcinoma of the stomach and pancreas [20]. This treatment modality was introduced into the US and other countries and applied to a variety of malignant tumors [21].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of intraoperative radiotherapy targeted to the abdominal lymph node area in patients with esophageal carcinoma

Tamaki

Sasaki

Endo

et al. 2012

Journal of Radiation Research

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We investigated whether intraoperative radiotherapy (IORT) during curative surgery for esophageal carcinoma is useful or not. The cases of 117 patients diagnosed with thoracoabdominal esophageal carcinoma who underwent curative surgery between 1986 and 2007 were reviewed: 72 patients received IORT (IORT group) and 45 did not (non-IORT group). Upper abdominal lymphadenectomy was performed in 115 patients (98.5%). Seventy patients (59.8%) received chemotherapy and 80 patients (68.4%) received external radiotherapy. IORT encompassed the upper abdominal lymph node area. A single-fraction dose of 20–30 Gy was delivered using high-energy electrons. Median follow-up duration for patients was 7.4 years. The 5-year overall survival rate did not significantly differ between the IORT and non-IORT groups. However, the 5-year abdominal control rate was significantly higher in the IORT group (89.2%) than in the non-IORT group (72.9%; P = 0.022). We next focused on a patient subgroup with a primary lesion in the lower thoracic or abdominal esophagus or measuring >6 cm in length since this subgroup is probably at high risk of upper abdominal lymph node metastasis. Of the 117 patients, 75 belonged to this subgroup, and among them 45 received IORT. Both univariate and multivariate analysis revealed the survival rate was significantly higher in patients who received IORT than in those who did not (P = 0.033 univariate; 0.026 multivariate). There were no obvious perioperative complications solely attributed to IORT. IORT for esophageal carcinoma will likely be effective for patients with a primary lesion in the lower thoracic or abdominal esophagus, or with a long lesion.

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Intra-Operative Irradiation in Abdominal and Cerebral Tumours

Cited by 56 publications

References 3 publications

Local Recurrence Rates in Breast Cancer Patients Treated with Intraoperative Electron-Boost Radiotherapy Versus Postoperative External-Beam Electron-Boost Irradiation

Local Recurrence Rates in Breast Cancer Patients Treated with Intraoperative Electron-Boost Radiotherapy Versus Postoperative External-Beam Electron-Boost Irradiation

Intraoperative radiation therapy

Efficacy of intraoperative radiotherapy targeted to the abdominal lymph node area in patients with esophageal carcinoma

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