Intra-operative dexmedetomidine reduces early postoperative nausea but not vomiting in adult patients after gynaecological laparoscopic surgery

Geng, Zhiyu; Liu, Yafei; Wang, Shanshan; Wang, Dong‐Xin

doi:10.1097/eja.0000000000000491

Cited by 35 publications

(32 citation statements)

References 18 publications

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“…As an adjuvant to general anesthesia, dexmedetomidine provides additional benefits of reducing the dose of inhalation agent and opioid analgesics [910], improving the quality of recovery, decreasing postoperative nausea and vomiting [911], and enhancing postoperative gastrointestinal motility [12]. Gupta et al [7] also show that dexmedetomidine infusion allows significant reductions in the amounts of isoflurane and intraoperative fentanyl required, while maintaining the targeted blood pressure.…”

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confidence: 99%

An introduction to the various role of dexmedetomidine

Kim

2016

Korean J Anesthesiol

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confidence: 99%

An introduction to the various role of dexmedetomidine

Kim

2016

Korean J Anesthesiol

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“…We used the methodology previously described by our recent study [8].Participant screening was performed the day before surgery. The inclusion criteria were: (1) female patients; (2) Neo-adjuvant chemoradiotherapy before surgery, (9) alcoholism or drug abuse, (10) any regimen of antiemetic, glucocorticoids or psychotropic drugs which are known to have an influence on the occurrence of PONV within 24h before surgery.…”

Section: Participants Selectionmentioning

confidence: 99%

“…Study sample size was calculated according to our previous studies [3,8],we estimated an incidence of PONV of 50% in the control group for this patient population. A sample size of 55 patients in each group was needed to detect a 50% reduction in the incidence of PONV (from 50 to 25%) with a power of 80% and a two-sided α error of 0.05.…”

Section: Samplesize Calculationmentioning

confidence: 99%

Adding dexmedetomidine to morphine-based analgesia reduces early postoperative nausea in patients undergoing gynecological laparoscopic surgery: A randomized controlled trial

Liu

Geng

et al. 2019

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Background: Few studies have investigated the effect of dexmedetomidine on postoperative nausea and vomiting (PONV) in patients underwent gynecological laparoscopic surgery. We investigated if adding dexmedetomidine to a morphine-based patient-controlled analgesia (PCA) could decrease the incidence of PONV in this high-risk patient population. Methods: In this prospective, randomized, double-blind and placebo-controlled study, 122 patients underwent gynecological laparoscopic surgery were assigned into two groups. Patients in the dexmedetomidine group (Group Dex) received a loading dose of dexmedetomidine 0.4μg/kg before the end of surgery, followed by morphine 0.5mg/ml plus dexmedetomidine 1μg/ml for postoperative i.v. PCA. Patients in the control group (Group Ctrl) received normal saline before the end of surgery, followed by morphine 0.5mg/ml alone for postoperative i.v. PCA. PCA pump was programmed as followed: bolus dose 2ml, lockout interval 8 minutes and background infusion at a rate of 1ml/h. The primary outcome was the incidence of nausea and vomiting within the first postoperative 24 hours. Results: Although there were no significant differences in regard to the total incidence of PONV (41.0% vs 52.5%, P=0.204), PONV We thank Ms.

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“…We used the methodology previously described by our recent study [8]. Participant screening was performed the day before surgery.…”

Section: Participants Selectionmentioning

confidence: 99%

“…In our previous study, we demonstrated that intraoperative supplemental use of dexmedetomidine resulted in a lower incidence of nausea during the first 2 h postoperatively for patients undergoing gynecological laparoscopic surgery [8]. Other studies about susceptible patients who underwent gynecological laparoscopic surgery were also focused on the intraoperative use of dexmedetomidine other than adding dexmedetomidine to patient-controlled analgesia (PCA) regimen [9][10][11][12].…”

mentioning

confidence: 99%

Adding dexmedetomidine to morphine-based analgesia reduces early postoperative nausea in patients undergoing gynecological laparoscopic surgery: A randomized controlled trial

Liu

Geng

et al. 2019

Preprint

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Purpose: Few studies have investigated the effect of dexmedetomidine on postoperative nausea and vomiting (PONV) in patients following gynecological laparoscopic surgery. We investigated if adding dexmedetomidine to a morphine-based patient-controlled analgesia (PCA) could reduce the incidence of PONV in this patient population. Methods: In this double-blind randomized-controlled trial,122 patients undergoing gynaecological laparoscopic surgery were randomly allocated to receive either a mixture of dexmedetomidine 1μg ml-1 and morphine 0.5mg ml-1 (Group Dex) or morphine 0.5mg ml-1 alone (Group Ctrl) for postoperative i.v. PCA. PCA pump was programmed as followed: bolus dose 2ml, lockout interval 8 minutes and background infusion at a rate of 1ml h-1. The primary outcome was the incidence of nausea and vomiting within 24 hours after operation. Results: The incidence of nausea and total PONV during the first 2h period was significantly lower in the Group Dex than in the Group Ctrl (10% vs 25%, P=0.031 and 0.031, respectively). There were no significant differences in regard to the total incidence of PONV (41% vs 52%, P=0.204), PONV score, time to first onset of PONV, or the need for rescue antiemetics in the first 24 hr following surgery between the two groups. Conclusions: For female patients undergoing gynecological laparoscopic surgery, adding dexmedetomidine to morphine-based PCA reduced the incidence of early postoperative nausea but not total PONV within 24h after surgery.

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Intra-operative dexmedetomidine reduces early postoperative nausea but not vomiting in adult patients after gynaecological laparoscopic surgery

Abstract: Chinese Clinical Trial Registry ChiCTR-IPR-15006914.

Cited by 35 publications

References 18 publications

An introduction to the various role of dexmedetomidine

An introduction to the various role of dexmedetomidine

Adding dexmedetomidine to morphine-based analgesia reduces early postoperative nausea in patients undergoing gynecological laparoscopic surgery: A randomized controlled trial

Adding dexmedetomidine to morphine-based analgesia reduces early postoperative nausea in patients undergoing gynecological laparoscopic surgery: A randomized controlled trial

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