Intra-Mode Squeezing in the Quantum Optical Frequency Comb

Godek, Benjamin

doi:10.18130/v3q814r7v

Cited by 1 publication

(1 citation statement)

References 16 publications

(30 reference statements)

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“…163 For example, the attachment of chromosomes to spindle microtubules through kinetochores during mitosis is essential for genome integrity. The dynamic of kinetochore-microtubule (k-MT) attachment is regulated by multiple enzymes (Figure 20B), 164 such as polo-like kinase 1 (PLK1), aurora B kinase (AURKB), cyclin-cyclin-dependent kinases (CDKs), and phosphatases PP1 and PP2A. These enzymes regulate the phosphorylation status of their substrates (e.g., kinesin family member 2B (KIF2B), BUB1-related kinase 1 (BUBR1), biorientation of chromosomes in cell division 1 (BOD1), and survivins), thus collectively controlling the k-MT attachment stability.…”

Section: Intracellular Ensmentioning

confidence: 99%

Enzymatic Noncovalent Synthesis

et al. 2020

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Enzymatic reactions and noncovalent (i.e., supramolecular) interactions are two fundamental nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process where enzymatic reactions control intermolecular noncovalent interactions for spatial organization of higher-order molecular assemblies that exhibit emergent properties and functions. Like enzymatic covalent synthesis (ECS), in which an enzyme catalyzes the formation of covalent bonds to generate individual molecules, ENS is a unifying theme for understanding the functions, morphologies, and locations of molecular ensembles in cellular environments. This review intends to provide a summary of the works of ENS within the last decade and emphasize ENS for functions. After comparing ECS and ENS, we describe a few representative examples where nature uses ENS, as a rule of life, to create the ensembles of biomacromolecules for emergent properties/functions in a myriad of cellular processes. Then, we focus on ENS of man-made (synthetic) molecules in cell-free conditions, classified by the types of enzymes. After that, we introduce the exploration of ENS of man-made molecules in the context of cells by discussing intercellular, peri/intracellular, and subcellular ENS for cell morphogenesis, molecular imaging, cancer therapy, and other applications. Finally, we provide a perspective on the promises of ENS for developing molecular assemblies/processes for functions. This review aims to be an updated introduction for researchers who are interested in exploring noncovalent synthesis for developing molecular science and technologies to address societal needs.

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Section: Intracellular Ensmentioning

confidence: 99%