Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

Kim, Sangpil; Kim, Ju-Hee; Jana, Batakrishna; Ryu, Ja‐Hyoung

doi:10.1039/d0ra07471c

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…[20][21][22][23] To date, a considerable amount of research has been performed to develop mitochondria-localized anticancer agents by using supramolecular systems without the aid of a drug. [24][25][26][27][28][29][30][31][32][33][34][35] These systems were formulated in situ only inside the cancerous mitochondria by self-assembly, [24][25][26][27][28][29][30][31] aggregation, [32,33] polymerization, [34] or mineralization, [35] disrupting the mitochondrial function for cell death. Of the most relevance to this work, we previously reported a thiol-containing functional monomer modified with a mitochondria-targeting triphenylphosphonium (TPP).…”

Section: Introductionmentioning

confidence: 99%

Drug‐Loaded Nanogel for Efficient Orchestration of Cell Death Pathways by Intramitochondrial Disulfide Polymerization

Choi,

Kim,

Kim

et al. 2023

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Chemotherapy using a nanoscaled drug delivery system is an effective cancer therapy, but its high drug concentration often causes drug resistance in cancer cells and normal cell damage. Combination therapy involving two or more different cell signaling pathways can be a powerful tool to overcome the limitations of chemotherapy. Herein, this article presents nanogel (NG)‐mediated co‐delivery of a chemodrug camptothecin (CPT) and mitochondria‐targeting monomer (MT monomer) for efficient activation of two modes of the programmed cell death pathway (apoptosis and necroptosis) and synergistic enhancement of cancer therapy. CPT and the monomer are incorporated together into the redox‐degradable polymeric NGs for release in response to the intracellular glutathione. The MT monomer is shown to undergo reactive oxygen species (ROS)‐triggered disulfide polymerization inside the cancerous mitochondria in cooperation with the chemotherapeutic CPT elevating the intracellular ROS level. The CPT/monomer interconnection in cell death mechanisms for mitochondrial dysfunction and enhanced cell death is evidenced by a series of cell analyses showing ROS generation, mitochondria damage, impacts on (non)cancerous or drug‐resistant cells, and cell death modes. The presented work provides beneficial insights for utilizing combination therapy to facilitate a desired cell death mechanism and developing a novel nanosystem for more efficacious cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Drug‐Loaded Nanogel for Efficient Orchestration of Cell Death Pathways by Intramitochondrial Disulfide Polymerization

Choi,

Kim,

Kim

et al. 2023

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Intracellular Chemical Reaction‐Induced Self‐Assembly for the Construction of Artificial Architecture and Its Functions

Kim,

Park,

Kim

et al. 2024

Advanced NanoBiomed Research

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Intracellular assemblies play vital roles in maintaining cellular functions through structural recognition‐mediated interactions. The introduction of artificial structures has garnered substantial interest in modulating cellular functions via activation/inhibition interactions with biomacromolecules. However, the cellular uptake of these high‐molecular‐weight structures may limit their performance. Recently, intracellular chemical‐reaction‐induced self‐assembly has emerged as a promising strategy for generating in situ nanostructures with biofunctionalities for interacting with biomacromolecules. This approach addresses the challenge of synthetic reactions occurring in complex intracellular environments by utilizing diverse chemical reactions that respond to endogenous and exogenous stimuli. This review provides an overview of the latest advancements in intracellular chemical‐reaction‐induced self‐assembly techniques. It focuses on their responsiveness to specific endogenous conditions, such as redox environments and overexpressed enzymes. Additionally, the initiation of chemical reactions through exogenous stimuli, including chemical reagents and irradiation is explored. Polymerization‐induced hydrophobicity is highlighted, leading to self‐assembly into micro‐/nanostructures. These processes contribute to the in situ construction of synthetic materials with diverse morphologies, offering versatile functionalities for biological applications.

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Folic acid functionalized aggregation-induced emission nanoparticles for tumor cell targeted imaging and photodynamic therapy

et al. 2022

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Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

Abstract: Controlled intracellular chemical reactions to regulate cellular function remain a challenge in biology mimetic systems.

Cited by 4 publications

References 30 publications

Drug‐Loaded Nanogel for Efficient Orchestration of Cell Death Pathways by Intramitochondrial Disulfide Polymerization

Drug‐Loaded Nanogel for Efficient Orchestration of Cell Death Pathways by Intramitochondrial Disulfide Polymerization

Intracellular Chemical Reaction‐Induced Self‐Assembly for the Construction of Artificial Architecture and Its Functions

Folic acid functionalized aggregation-induced emission nanoparticles for tumor cell targeted imaging and photodynamic therapy

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