Intra-individual variability in the response to anodal transcranial direct current stimulation

López-Alonso, Virginia; Fernández-del-Olmo, Miguel; Costantini, Alessia; González-Henríquez, Juan José; Cheeran, Binith

doi:10.1016/j.clinph.2015.03.022

Cited by 156 publications

(132 citation statements)

References 36 publications

Supporting

Mentioning

108

Contrasting

Order By: Relevance

“…Previous evidence regarding stability of anodal effects has been mixed. Our results are more in line with the recent findings of Horvath et al (2016) than those of Lopez-Alonso et al (2015). However, as previously noted there are methodological differences between the studies which may in part contribute to the findings.…”

Section: Inspection Ofsupporting

confidence: 92%

“…However, as previously noted there are methodological differences between the studies which may in part contribute to the findings. In particular the study by Lopez-Alonso et al (2015) was conducted with sessions separated by 6-12 months and only two sessions were compared, although it should be noted that this work was conducted with a larger sample. Our finding of moderate stability following sham stimulation is also in agreement with previous work (Horvath et al, 2016).…”

Section: Inspection Ofmentioning

confidence: 99%

“…A few notable studies have explored these issues for anodal stimulation at 1mA (Horvath et al, 2016;Lopez-Alonso et al, 2015) and at 0.5mA (Chew et al, 2015). Interestingly, although 1mA anodal tDCS was found to have a reasonable level of inter-subject reliability (Lopez-Alonso et al, 2015), the same was not true of 0.5mA (Chew et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

et al. 2016

View full text Add to dashboard Cite

. (2016) Intrasubject consistency and reliability of response following 2mA transcranial direct current stimulation. Brain Stimulation, 9 (6). pp. 819-825. ISSN 1876-4754 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/34423/1/Dyke%20et%20al%2018-6-16.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Intra-subject consistency and reliability of response following 2mA transcranial direct current stimulation Abstract BackgroundTranscranial direct current stimulation (tDCS) is a popular non-invasive brain stimulation technique that has been shown to influence cortical excitability. While polarity specific effects have often been reported, this is not always the case, and variability in both the magnitude and direction of the effects have been observed. Objective/ hypothesisWe aimed to explore the consistency and reliability of the effects of tDCS by investigating changes in cortical excitability across multiple testing sessions in the same individuals. A within subjects design was used to investigate the effects of anodal and cathodal tDCS applied to the motor cortex. Four experimental sessions were tested for each polarity in addition to two sham sessions. MethodsTranscranial Magnetic Stimulation (TMS) was used to measure cortical excitability (TMS recruitment curves). Changes in excitability were measured by comparing baseline measures and those taken immediately following 20minutes of 2mA stimulation or sham stimulation. ResultsAnodal tDCS significantly increased cortical excitability at a group level, whereas cathodal tDCS failed to have any significant effects. The sham condition also failed to show any significant changes.Analysis of intra-subject responses to anodal stimulation across four sessions suggest that the amount of change in excitability across sessions was only weakly associated, and was found to have poor reliability acro...

show abstract

Section: Inspection Ofsupporting

confidence: 92%

Section: Inspection Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Recent studies have shown that even the influence of stimulation on motor-evoked potentials-the primary proof of tDCS efficacy in humans-is subject to high inter- (López-Alonso et al 2014;Strube et al 2016;Wiethoff et al 2014) and intraindividual variability (Dyke et al 2016;Horvath et al 2015b;López-Alonso et al 2015). The ultimate solution may be to tailor stimulation dosage and placement of electrodes to individual brains, but this requires sophisticated computational modeling efforts that are only just getting under way (Berker et al 2013;Bikson et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Transcranial Electrical Stimulation as a Tool to Enhance Attention

et al. 2017

View full text Add to dashboard Cite

Attention is a fundamental cognitive process-without it, we would be helplessly adrift in an overload of sensory input. There is considerable interest in techniques that can be used to enhance attention, including transcranial electrical stimulation (tES). We present an overview of 52 studies that have paired attention tasks with tES, mostly in the form of transcranial direct current stimulation (tDCS). In particular, we discuss four aspects of attention that have been most extensively targeted to date: visual search, spatial orienting (e.g., Posner cueing tasks), spatial bias (e.g., line bisection tasks), and sustained attention. Some promising results have been reported in each of these domains. However, drawing general conclusions about the efficacy of tES is at present hampered by a large diversity in study design and inconsistent findings. We highlight some pitfalls and opportunities and suggest how these may be addressed in future research aiming to use tES as a tool to enhance or test theoretical hypotheses about attention.

show abstract

“…the ability of tDCS to produce similar outcomes in an individual when multiple identical sessions of tDCS are applied on separate occasions. López-Alonso et al [21] showed overall poor individual reliability of response to two identical anodal tDCS sessions performed 6-12 months apart. Although this time frame is not typically used, the findings provide important preliminary data considering the large number of studies that attempt to draw conclusions from single sessions of tDCS.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Inter- and Intra-individual Variability in Response to Transcranial Direct Current Stimulation (tDCS) at Varying Current Intensities

2015

View full text Add to dashboard Cite

Intra-individual variability in the response to anodal transcranial direct current stimulation

Cited by 156 publications

References 36 publications

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

Transcranial Electrical Stimulation as a Tool to Enhance Attention

Inter- and Intra-individual Variability in Response to Transcranial Direct Current Stimulation (tDCS) at Varying Current Intensities

Contact Info

Product

Resources

About