Intra-individual methylomics detects the impact of early-life adversity

Jiang, Shan; Kamei, Noriko; Bolton, Jessica L.; Ma, Xinyi; Baram, Tallie Z.; Mortazavi, A

doi:10.26508/lsa.201800204

Cited by 9 publications

(22 citation statements)

References 42 publications

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“…The risk factors for OUD are numerous and complex, and genetics (Kreek et al, 2012 ; Crist et al, 2019 ; Jiang et al, 2019 ), drug availability (Volkow et al, 2011 ; Wright et al, 2014 ), and environmental factors such as early life adversity (ELA; Dube et al, 2003 ; Sinha, 2008 ; Kreek et al, 2012 ) all play a role. ELA related to poverty, trauma and chaotic environment affects over 30% of children in the U.S. (American Psychological Association, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The Developmental Origins of Opioid Use Disorder and Its Comorbidities

Levis

Mahler

Baram

2021

Front. Hum. Neurosci.

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Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, exposure to prescription opioids, and environmental risks. Crucially, one key environmental risk factor for OUD is early life adversity (ELA). OUD and other substance use disorders are widely considered to derive in part from abnormal reward circuit function, which is likely also implicated in comorbid mental illnesses such as depression, bipolar disorder, and schizophrenia. ELA may disrupt reward circuit development and function in a manner predisposing to these disorders. Here, we describe new findings addressing the effects of ELA on reward circuitry that lead to OUD and comorbid disorders, potentially via shared neural mechanisms. We discuss some of these OUD-related problems in both humans and animals. We also highlight the increasingly apparent, crucial contribution of biological sex in mediating the range of ELA-induced disruptions of reward circuitry which may confer risk for the development of OUD and comorbid neuropsychiatric disorders.

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Section: Introductionmentioning

confidence: 99%

The Developmental Origins of Opioid Use Disorder and Its Comorbidities

Levis

Mahler

Baram

2021

Front. Hum. Neurosci.

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“…Similarly, a broad trend toward DNA hypermethylation associated with atherosclerotic plaque progression has been observed ( Valencia-Morales et al, 2015 ; Gallego-Fabrega et al, 2020 ). In addition, increased DNA methylation levels have been documented in elderly patients with myocardial infarction and CHD and have shown a positive correlation with the degree of coronary atherosclerosis ( Jiang et al, 2019 ).…”

Section: Circulating Biomarkers Related To Vascular Agingmentioning

confidence: 99%

Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216

et al. 2021

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Impairment of the arteries is a product of sustained exposure to various deleterious factors and progresses with time; a phenomenon inherent to vascular aging. Oxidative stress, inflammation, the accumulation of harmful agents in high cardiovascular risk conditions, changes to the extracellular matrix, and/or alterations of the epigenetic modification of molecules, are all vital pathophysiological processes proven to contribute to vascular aging, and also lead to changes in levels of associated circulating molecules. Many of these molecules are consequently recognized as markers of vascular impairment and accelerated vascular aging in clinical and research settings, however, for these molecules to be classified as biomarkers of vascular aging, further criteria must be met. In this paper, we conducted a scoping literature review identifying thirty of the most important, and eight less important, biomarkers of vascular aging. Herein, we overview a selection of the most important molecules connected with the above-mentioned pathological conditions and study their usefulness as circulating biomarkers of vascular aging.

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“…The difficulty in identifying predictive biomarkers for cognitive defects and dementia in these cross-sectional studies derives from the considerable variance among individuals. Longitudinal and within-individual comparisons are now emerging 230,231 . These comparisons hold promise for uncovering methylation patterns that might be predictive markers for the risk of cognitive problems or dementia later in life.…”

Section: Epigenetics and Methylomic Biomarkersmentioning

confidence: 99%

Early-life adversity and neurological disease: age-old questions and novel answers

2019

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Neurological illnesses, including cognitive impairment, memory decline and dementia, affect over 50 million people worldwide, imposing a substantial burden on individuals and society. These disorders arise from a combination of genetic, environmental and experiential factors, with the latter two factors having the greatest impact during sensitive periods in development. In this Review , we focus on the contribution of adverse early-life experiences to aberrant brain maturation, which might underlie vulnerability to cognitive brain disorders. Specifically , we draw on recent robust discoveries from diverse disciplines, encompassing human studies and experimental models. These discoveries suggest that early-life adversity , especially in the perinatal period, influences the maturation of brain circuits involved in cognition. Importantly , new findings suggest that fragmented and unpredictable environmental and parental signals comprise a novel potent type of adversity , which contributes to subsequent vulnerabilities to cognitive illnesses via mechanisms involving disordered maturation of brain 'wiring'.

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Intra-individual methylomics detects the impact of early-life adversity

Cited by 9 publications

References 42 publications

The Developmental Origins of Opioid Use Disorder and Its Comorbidities

The Developmental Origins of Opioid Use Disorder and Its Comorbidities

Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216

Early-life adversity and neurological disease: age-old questions and novel answers

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