Intra-cerebellar schwannoma with various degenerative changes: a case report and a systematic review

Abstract

Background Intra-cranial schwannomas account for less than 8% of brain tumors, among which more than 80% arise from the vestibular nerve. Intra-cerebellar schwannomas are extremely rare. Several cases have been previously reported but without remarkable degenerative changes on histology. Case presentation A 61-year-old man presented with worsening disorientation, and an imaging study revealed a cystic lesion (6.5 cm in the largest diameter) in the left hemisphere of the cerebellum accompanied by a mural nodule (2.5 cm) located just inside the skull with enhancement and focal calcification, in addition to hydrocephalus. The lesion was more than 5 mm from the left acoustic nerve. The patient underwent gross total resection. Pathological examination revealed remarkable degenerative changes with various morphological features. Tumor cells were pleomorphic with rich cytoplasm containing numerous eosinophilic granules. Blood vessels and extracellular matrix showed remarkable hyalinization. Immunohistochemical staining revealed that the tumor cells were positive for S-100 protein and negative for Olig2. The tumor was diagnosed as a schwannoma with marked degenerative changes. Conclusions The present case is discussed with reference to a systematic review of previous reports of intra-cerebellar schwannoma. Intra-cerebellar schwannoma should be included in the differential diagnosis of cystic lesions with heterogeneous histopathological morphology in the cerebellum.

Case Report: Adrenal glands degenerated schwannoma: Report of three cases and literature review

“…It contains multiple subtypes. For example, classic schwannoma, degenerated schwannoma, cellular schwannoma, plexiform schwannoma, etc (1,3). Schwannomas usually arise in the spinal nerve roots, intracranial nerves, and extremities (4).…”

“…It a benign tumor. Degenerated schwannoma is a subtype of schwannoma (1,2). Degenerated schwannoma in the adrenal gland is extremely rare.…”

A novel SREBF1::NACC1 gene fusion in an unclassifiable intracranial tumour

“…To identify all full-text, peer-reviewed publications describing the detailed clinical findings of tumours with fusions associated with NACC1, a systematic review was performed according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), as previously described [14,15] (Figure S1).…”

“…To identify all full‐text, peer‐reviewed publications describing the detailed clinical findings of tumours with fusions associated with NACC1 , a systematic review was performed according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA), as previously described [14, 15] (Figure S1). To date, in combination with the present case, a total of 10 cases of tumours associated with NACC1 fusions have been reported in the English‐language literature [13, 16, 17] (Table S5).…”

Intracerebral giant schwannoma of the skull base misinterpreted as a macroprolactinoma

“…Because of a bone erosion and the typical location at the skull base (off the midline), chondrosarcoma of the sphenoid wing was also considered, while a schwannoma was not taken under preoperative considerations [4]. Approximately 90% of intracranial schwannomas arise in cerebellopontine angles in relation to the vestibular nerve [5]. The case we showed is extremely rare and could be a diagnostic problem for specialists.…”