Intra-Cavernosal Injection of Botulinum Toxin in the Treatment of Erectile Dysfunction: a Systematic Review and Meta-Analysis

Zahr, Rawad Abou; Kheir, George Bou; Mjaess, Georges; Jabbour, Teddy; Chalhoub, Khalil; Diamand, Romain; Roumeguère, Thierry

doi:10.1016/j.urology.2022.08.039

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Since 1982, some ED sufferers have been consistently self-administering injections of medications, such as botulinum toxin, directly into the corpus cavernosum as a means of treatment. However, this self-injection method poses significant challenges, and the use of ICI in China remains relatively limited due to the requirement for specialized expertise and associated discomfort [ 17 ]. Through the literature review, there have been 16 reported cases of self-insertion of needle-like foreign bodies into the cavernous body of the penis.…”

Section: Discussionmentioning

confidence: 99%

Migrating foreign bodies of penis: a case report and literature review

Yang,

Ke,

Qiu

et al. 2024

Basic Clin. Androl.

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Background Only a few cases have been reported about active foreign body implantation in the cavernous body of the penis. Case presentation A 47-year-old man inserted two needles from the glans penis into the bilateral penile sponge body. Subsequently, two needles migrated through the penile cavernous body into the pelvic cavity. Attempts to remove the needles through the penis were unsuccessful. Eventually, after a duration exceeding one month, the displaced needles were removed in stages from the buttocks. Conclusion A few cases of intracavernosal-injection-therapy-associated needle breakage and retention have been reported globally. And this is the first case in China documenting the migration of foreign bodies within the penile region. In this condition, it is of utmost importance to engage the expertise of experienced andrologists to minimize the risk of excessive manipulation, thereby ensuring that inadvertent deep penetration of the needle into the penile tissue is prevented. In case the foreign body has migrated deeper into the tissues and the patient does not exhibit any specific symptoms or risks of macrovascular injury-related bleeding, close surveillance of its movement can be implemented. Surgical intervention can be initiated once the foreign body has reached a suitable position. Moreover, a psychiatric evaluation should be recommended for patient to discover any underlying mental health disorders.

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Section: Discussionmentioning

confidence: 99%

Migrating foreign bodies of penis: a case report and literature review

Yang,

Ke,

Qiu

et al. 2024

Basic Clin. Androl.

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Direct Application Therapy for Erectile Dysfunction

Heckscher,

Grinnan,

Bieniek

et al. 2024

Reference Module in Biomedical Sciences

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Clinical Conditions Targeted by OnabotulinumtoxinA in Different Ways in Medicine

Onan,

Farham,

Martelletti

2024

Toxins

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OnabotulinumtoxinA (BT-A) is used in different medical fields for its beneficial effects. BT-A, a toxin originally produced by the bacterium Clostridium botulinum, is widely known for its ability to temporarily paralyze muscles by blocking the release of acetylcholine, a neurotransmitter involved in muscle contraction. The literature continually reports new hypotheses regarding potential applications that do not consider blockade of acetylcholine release at the neuromuscular junction as a common pathway. In this opinion article, it is our aim to investigate the different pathway targets of BT-A in different medical applications. First of all, the acetylcholine effect of BT-A is used to reduce wrinkles for cosmetic purposes, in the treatment of urological problems, excessive sweating, temporomandibular joint disorders, obesity, migraine, spasticity in neurological diseases, and in various cases of muscle overactivity such as cervical dystonia, blepharospasm, and essential head tremor. In another potential pathway, glutamate A, CGRP, and substance P are targeted for pain inhibition with BT-A application in conditions such as migraine, trigeminal neuralgia, neuropathic pain, and myofascial pain syndrome. On the other hand, as a mechanism different from acetylcholine and pain mediators, BT-A is used in the treatment of hair loss by increasing oxygenation and targeting transforming growth factor-beta 1 cells. In addition, the effect of BT-A on the apoptosis of cancer cells is also known and is being developed. The benefits of BT-A applied in different doses to different regions for different medical purposes are shown in literature studies, and it is also emphasized in those studies that repeating the applications increases the benefits in the long term. The use of BT-A continues to expand as researchers discover new potential therapeutic uses for this versatile toxin.

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Intra-Cavernosal Injection of Botulinum Toxin in the Treatment of Erectile Dysfunction: a Systematic Review and Meta-Analysis

Cited by 3 publications

References 27 publications

Migrating foreign bodies of penis: a case report and literature review

Migrating foreign bodies of penis: a case report and literature review

Direct Application Therapy for Erectile Dysfunction

Clinical Conditions Targeted by OnabotulinumtoxinA in Different Ways in Medicine

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