Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response.

Gaffney, Karl; Ledingham, Joanna; Perry, Janet

doi:10.1136/ard.54.5.379

Cited by 217 publications

(166 citation statements)

References 15 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…The durability of benefit of intraarticular therapies is limited. In placebo-controlled clinical trials, the duration of benefit following corticosteroid injection is 1-8 weeks; for hyaluronate, the expected benefit is 12-52 weeks (8)(9)(10)(11)(12). Furthermore, the effectiveness of each of these treatment options is limited.…”

mentioning

confidence: 99%

Tidal irrigation as treatment for knee osteoarthritis: A sham-controlled, randomized, double-blinded evaluation

Bradley¹,

Heilman²,

Katz³

et al. 2002

Arthritis & Rheumatism

106

View full text Add to dashboard Cite

mentioning

confidence: 99%

Tidal irrigation as treatment for knee osteoarthritis: A sham-controlled, randomized, double-blinded evaluation

Bradley¹,

Heilman²,

Katz³

et al. 2002

Arthritis & Rheumatism

106

View full text Add to dashboard Cite

“…USG guidance was not used in any of the previous studies evaluating the effect of IA corticosteroids in knee osteoarthritis [4,5]. Moreover, the applied dose was smaller than the ACR recommended dose [12][13][14]. Application of the recommended dose under USG guidance may have ameliorated the analgesic effect in this study even the patient group had advanced osteoarthritis.…”

Section: Discussionmentioning

confidence: 90%

“…Gaffney et al [12] conducted a study to compare 20 mg IA triamcinolone hexacetonide with placebo in knee osteoarthritis and reported significant improvement in pain with triamcinolone at the end of the first week. However, there was no difference between the groups at the end of 6 weeks.…”

Section: Discussionmentioning

confidence: 99%

The effect of ultrasonography guided intra-articular corticosteroid injections in advanced knee osteoarthritis

Koçyiğit¹,

Kuyucu²,

Koçyi̇ği̇t³

2015

Pau Med J

View full text Add to dashboard Cite

Purpose: The aim of the study is to evaluate the effect of ultrasonography-guided intra-articular corticosteroid injection on pain, functional status and quality of life in patients with advanced knee osteoarthrit. Materials and methods: 50 knees of 26 patients who were diagnosed as grade 4 knee osteoarthritis according to Kellgren -Lawrence classification system were treated with ultrasonography-guided intra-articular injection of 40 mg triamcinolone acetonide. Perceived pain, weekly analgesic consumption, findings of physical examination, knee pain threshold, functional status and quality of life were evaluated before and four weeks after the injection. Western -Ontario and McMaster Universities' (WOMAC) osteoarthritis index was used to assess functional status, and Nottingham Health Profile (NHP) was used to evaluate the quality of life. Results: Mean age of the patients in the study was 65±7.5 years and mean symptom duration was 74.7± 32.5 months. Visual analog scale for pain decreased from 85.3.±14.1 mm to 59, 6±21.1 mm (p=0.003) and mean analgesic consumption decreased from 8±3 to 3±2 (p=0.000). Total WOMAC score (p=0.000) and scores of 4 NHP subdivisions (pain (p=0.000); physical mobility (p=0.003), social isolation (p=0.012); emotional reactions (p=0.016) decreased significantly 4 weeks after the injection. Conclusion: Injection under ultrasonography guidance may improve the beneficial effects of corticosteroids in advanced knee osteoarthritis.Pam Med J 2015;8(3):193-198 Key words: intraarticular injection, corticosteroids, osteoarthritis; interventional ultrasonography. ÖzetAmaç: Bu çalışmanın amacı ileri evre diz osteorartriti olan hastalarda, ultrasonografi eşliğinde yapılan intraartiküler kortikosteroid enjeksiyonlarının, ağrı, fonksiyonel durum ve hayat kalitesi üzerine olan etkilerinin araştırılmasıdır. Gereç ve yöntem: Kellgren -Lawrence sınıflandırma sistemine göre evre 4 diz osteoartriti olan 26 hastanın 50 dizine ultrasonografi eşliğinde intraartiküler 40 mg triamsinolon asetonid uygulandı. Hastanın algıladığı ağrı, haftalık analjezik ilaç ihtiyacı, fizik muayene bulguları, diz ağrı eşiği, fonksiyonel durum ve yaşam kalitesi enjeksiyondan önce ve 4 hafta sonar değerlendirildi. Fonksiyonel durumun değerlendirilmesi için WesternOntario ve McMaster Üniversiteleri (WOMAC) osteoartrit indeksi, yaşam kalitesinin değerlendirilmesi için Nottingham Sağlık Profili (NHP) kullanıldı. Bulgular: Çalışmaya dahil edilen hastaların ortalama yaşı 65±7.5 yıl, belirti süresi 74.7± 32.5 aydı. Ağrı için vizüel analog skala 85,3±14.1 mm den 59,6±21,1 mm'ye (p=0.003); haftalık analjezik tüketimi 8±3 tabletten 3±2 tablete (p=0.000) geriledi. Toplam WOMAC skoru (p=0.000) ve NHP ağrı (p=0.000), fiziksel aktivite (p=0.003), sosyal izolasyon (p=0.012), emosyonel reaksiyonlar (p=0.016) skorları enjeksiyondan 4 hafta sonra istatistiksel olarak anlamlı şekilde azaldı. Sonuç: İleri evre diz osteartritinde enjeksiyonun ultrasonografi eşliğinde yapılması kortikosteroidlerin yararlarını arttırabilir.

show abstract

“…54 Nearly 80% of patients report improvement at 1 week. The clinical benefit is improved when effusion is present and aspiration of synovial fluid at the time of injection is successful (recommendation strength B).…”

Section: Office Interventionsmentioning

confidence: 99%

“…The clinical benefit is improved when effusion is present and aspiration of synovial fluid at the time of injection is successful (recommendation strength B). 54 It is not clear that frequent injections will damage articular cartilage or the joint's structure. In common practice, however, intra-articular steroid injections are limited to 3 to 4 per year (recommendation strength C).…”

Section: Office Interventionsmentioning

confidence: 99%

Managing Joint Pain in Primary Care

Palmer¹,

Toombs²

2004

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

Joint pain is a common problem seen by family physicians. Although many pain complaints arise from self-limited conditions, a substantial number require immediate and ongoing care. Prompt appropriate treatment can help limit symptoms, prevent disability, and improve outcomes. The differential diagnosis is varied, with both laboratory studies and diagnostic imaging available to help evaluate the joint. At the initial evaluation and at each subsequent re-evaluation, there should be efforts to identify dangerous conditions and distinguish conditions with a disease-specific pathogenesis. Treatment of joint pain consists of both pharmacologic and nonpharmacologic modalities. Pharmacologic therapies may include medications specific for pain, inflammation, and adjuncts specific to the diagnosis. Joint pain is a common complaint presented by patients to family physicians. Each year there are more than 315 million office visits for musculoskeletal complaints.

show abstract

Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response.

Cited by 217 publications

References 15 publications

Tidal irrigation as treatment for knee osteoarthritis: A sham-controlled, randomized, double-blinded evaluation

Tidal irrigation as treatment for knee osteoarthritis: A sham-controlled, randomized, double-blinded evaluation

The effect of ultrasonography guided intra-articular corticosteroid injections in advanced knee osteoarthritis

Managing Joint Pain in Primary Care

Contact Info

Product

Resources

About