Intra-articular injections of hyaluronic acid induce positive clinical effects in knees of patients affected by haemophilic arthropathy

Carulli, Christian; Matassi, Fabrizio; Civinini, Roberto; Morfini, Massimo; Tani, Massimiliano; Innocenti, Massimo

doi:10.1016/j.knee.2012.05.006

Cited by 38 publications

(55 citation statements)

References 13 publications

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“…Early prophylactic factor, viscosupplementation, avoidance of trauma and careful follow-up can prevent or delay arthropathy 3. Advanced joint disease, as seen here, is not uncommon in patients presenting from developing nations without early factor treatment.…”

Section: Descriptionmentioning

confidence: 62%

A bloody painful knee: delayed presentation of haemophilic arthropathy

2014

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Section: Descriptionmentioning

confidence: 62%

A bloody painful knee: delayed presentation of haemophilic arthropathy

2014

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“…Due to the recent improvements in the prevention of bleedings by primary or secondary haematologic prophylaxis, the most frequent complication of Haemophilia is the haemophilic arthropathy in specific joints, called "target joints" [59]. The most involved joint is the knee, and often the quality of life is poor due to the severity of symptoms and functional impairment: conservative treatments and minimally invasive procedures are rarely useful in such cases [60][61]. In the recent decades a high increase of the TKA performed in such patients has been recorded, given the fact that major surgery is the only procedure that may induce adequate pain relief and functional recovery [62][63].…”

Section: Vte Prophylaxis In Tkr In Haemophiliamentioning

confidence: 99%

Prophylaxis of Venous Thromboembolism in Knee Replacement Surgery

Rostagno¹,

Carulli²,

Cartei³

et al. 2016

Prog Orthop Sci

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Venous thromboembolism (VTE) is still a frequent and sometimes severe complication after knee replacement surgery. Both pharmacological and non-pharmacological measures have been widely used to decrease VTE risk. Non pharmacological treatment include measures directed to decrease the effects of blood stasis, intermittent pneumatic compression device (IPCD) and graduated compression stockings, and mechanical devices. Pharmacological prophylaxis of venous thromboembolism (VTE) is associated with a more significant decrease in the incidence of deep venous thrombosis (DVT) and related complications after knee arthroplasty however anticoagulation may increase the risk of postoperative bleeding and related complications, in particular the need for re-intervention. Aim of present review was to suggest practical approach to DVT prophylaxis in patients undergoing knee arthroplasty. Although parenteral drugs (low dose unfractionated heparin, low molecular weight heparin and fondaparinux) are the more frequently employed agents, limited compliance may be a concern. Recent studies suggest that direct oral anticoagulants, antithrombin and anti Xa agent, might be a useful alternative although safety may limited by an higher rate of local bleeding.

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“…Haematological prophylaxis, lifestyle modifications, physical and medical therapy may be useful for the modern prevention of arthropathy (7). In early stages of arthropathy, physical, medical therapy and conservative treatment by intraarticular injections (viscosupplementation and synoviorthesis with rifampicine) are usually successful (8). When such strategies are no longer effective or severe arthropathy realizes, orthopedic surgery is needed.…”

Section: Introductionmentioning

confidence: 99%

Orthopaedic procedures in haemophilia

Rizzo

Zago

Carulli

et al. 2017

ccmbm

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SummaryHaemophilia may nowadays be considered an "ortho paedic" disease given due to the involvement of musculoskeletal system in almost all haemophilic subjects. The modern haematological prophylaxis has dramatically improved the quality of life reducing bleedings and lifethreatening complications; however, joint bleedings, progressive and irreversible arthropathy and osteoporosis are still now common challenging issues to be faced. One of the tissues involved by Haemophilia is the bone, particularly in the periarticular zone: poor bone quality and decrease of bone stock are typical patterns, and the worse is the arthropathy, the greater the bone loss. The orthopaedic management of such condition is now mandatory and characterized by several surgical techniques. The purpose of this work is to provide an overview of these options derived from our experience in managing haemophilic patients.

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Intra-articular injections of hyaluronic acid induce positive clinical effects in knees of patients affected by haemophilic arthropathy

Cited by 38 publications

References 13 publications

A bloody painful knee: delayed presentation of haemophilic arthropathy

A bloody painful knee: delayed presentation of haemophilic arthropathy

Prophylaxis of Venous Thromboembolism in Knee Replacement Surgery

Orthopaedic procedures in haemophilia

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