Abstract:Osteoarthritis (OA) is a common joint disease characterized by progressive cartilage degeneration, which is regulated by oxidative stress, and there is currently no clinical drug to alleviate its development. Kartogenin (KGN) was found to treat cartilage damage in early OA, but its application is limited by the rapid clearance from synovial fluid. This study synthesized a KGN-loaded nanocarrier based on PLGA/polydopamine core/shell structure to treat OA. The prepared KGN@PLGA/PDA-PEG-E7 nanoparticles could sta… Show more
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