Intra articular injection of platelet rich plasma in grade 1 and 2 knee osteoarthritis and assessment of functional outcome: A longitudinal interventional study

Abstract

Osteoarthritis of knee joint is one of the most important problem which increases disability adjusted life year. Various modalities of treatment are available for the treatment of osteoarthritis of knee. Intra articular injection of platelet rich plasma in knee joint is also one of the treatment options available for osteoarthritis knee. This longitudinal interventional study is to evaluate the efficacy of single intra articular injection of platelet rich plasma in grade 1 and grade 2 osteoarthritis. Consent was received from the patients with knee osteoarthritis and was injected with intra articular injection of autologous platelet rich plasma intra articularly. Pre-injection WOMAC scores were analyzed and post-injection scores were analyzed at 1,3 and 6 th month. Results showed statistically significant report with decrease in WOMAC scores after injection. In conclusion, there is improvement in physical function and decrease in pain and stiffness in patients of knee osteoarthritis injected with single intra articular platelet rich plasma injection with effects confirmed by our study till six months post injection.

Single versus Three Doses of Intraarticular Platelet-Rich Plasma Injection in Treatment of Early Osteoarthritis Knee Joint—A Prospective Comparative Study

“…Filardo et al 8 used three injections of 5 mL volume each at 4 weeks interval and VAS and WOMAC scores were used to assess the outcome. Sooraj 9 et al did a study on 70 patients having early OA using a single injection of 5 mL and WOMAC scores were used to assess the outcome. Patel et al 10 did a study on 78 patients (156 knees) to compare the efficacy between single versus double dose of PRP the in treatment of early OA and WOMAC scores were used to assess the outcomes.…”

“…The safety and efficacy of PRP have been confirmed by previous studies. [7][8][9][10] Compared with hyaluronic acid, corticosteroids, autologous conditioned serum, and placebo, PRP has been found to have improved outcomes in recent studies. 8,[10][11][12][13] Our aim in this study is to compare the efficacy between single injection versus three-time injection of PRP for OA treatment.…”

“…The safety and efficacy of PRP have been confirmed by previous studies. 7 8 9 10 Compared with hyaluronic acid, corticosteroids, autologous conditioned serum, and placebo, PRP has been found to have improved outcomes in recent studies. 8 10 11 12 13…”