Intra-articular injection of platelet-rich plasma in patients with hemophilia and painful knee joint cartilage degeneration

Rodríguez-Merchán, E. Carlos

doi:10.1080/17474086.2023.2166922

Cited by 2 publications

(3 citation statements)

References 90 publications

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“…Data is yet to be validated, but preliminary reports show that PRP injections effectively reduce inflammation, pain, bleeding episodes and improves joint range of motion. 63 Minimally invasive orthopaedic procedures can truly grant PwH with haemophilic arthropathy years without pain. Success of minimally invasive procedures including arthroscopic synovectomy is dependent on careful patient screening and selection (young, timely intervention, early arthropathy), and a multidisciplinary approach with experienced haematologists, orthopaedic surgeons, and physiotherapists.…”

Section: Surgical Synovectomy and Minimally Invasive Orthopaedic Proc...mentioning

confidence: 99%

“…Lastly, platelet‐rich plasma (PRP) therapy is emerging as another minimally invasive orthopaedic procedure which relies on the chondroregenerative properties of growth factors in PRP for patients with haemophilic arthropathy and chronic synovitis. Data is yet to be validated, but preliminary reports show that PRP injections effectively reduce inflammation, pain, bleeding episodes and improves joint range of motion 63 …”

Section: Prevention and Management Of Haemophilic Arthropathymentioning

confidence: 99%

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Haemophilic arthropathy: Diagnosis, management, and aging patient considerations

Bakeer,

Saied,

Gavrilovski

et al. 2024

Haemophilia

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Gene therapy and universal use of safer, more effective, and personalised prophylactic regimens (factor, and nonfactor) are expected to prevent joint bleeding and promote joint health in persons with haemophilia (PwH). Growing evidence suggests that subclinical bleeding, with active and inactive synovial proliferation, continues and haemophilic arthropathy remains a major morbidity in PwH despite early institution of joint prophylaxis. Joint health assessment is evolving with physical examination scores complementing imaging scores. Point‐of‐care ultrasound is emerging as a safe, cost‐effective, and readily available tool for acute determination of musculoskeletal abnormalities, serial evaluation of joints for sonographic markers of haemophilic arthropathy, and in providing objective insight into the efficacy of new therapies. In acute haemarthrosis, arthrocentesis expedites recovery and prevent the vicious cycle of bleed‐synovitis‐rebleed. When synovial proliferation develops, a multidisciplinary team approach is critical with haematology, orthopaedics, and physiotherapy involvement. Synovectomy is considered for patients with chronic synovitis that fail conservative management. Non‐surgical and minimally invasive procedures should always be offered and considered first. Careful patient selection, screening and early intervention increase the success of these interventions in reducing bleeding, pain, and improving joint function and quality of life. Chemical synovectomy is practical in developing countries, but radioactive synovectomy appears to be more effective. When surgical synovectomy is considered, arthroscopic/minimally invasive approach should be attempted first. In advanced haemophilic arthropathy, joint replacement and arthrodesis can be considered. While excited about the future of haemophilia management, navigating musculoskeletal challenges in the aging haemophilia population is equally important.

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Section: Surgical Synovectomy and Minimally Invasive Orthopaedic Proc...mentioning

confidence: 99%

Section: Prevention and Management Of Haemophilic Arthropathymentioning

confidence: 99%

Haemophilic arthropathy: Diagnosis, management, and aging patient considerations

Bakeer,

Saied,

Gavrilovski

et al. 2024

Haemophilia

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“…Regarding intra‐articular therapy, hyaluronic acid (HA) has been used in clinical practice for the treatment of hemophilic arthropathy. Fernandez‐Palazzi et al first used intra‐articular HA injections for patients with hemophilia with arthropathy signing improving functional results [ 3 ]. Furthermore, intra‐articular platelet‐rich plasma (PRP) injection includes a natural concentrate of autologous growth factors from the blood, which are popular for their anti-inflammatory potential.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Hemophilic Arthropathy of the Knee: Treatment With Circular External Fixator and Intra-articular Injection of Platelet-Rich Plasma

Pappa,

Giannakopoulou,

Michalopoulou

et al. 2024

Cureus

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There are limited reports about managing knee flexion contracture (KFC) due to hemophilic hemarthrosis with the Ilizarov technique and platelet-rich plasma intraarticular injection administration. This article aims to describe a case of KFC treated with a circular external fixator and intraarticular administration of platelet-rich plasma in a pediatric patient. A 12-year-old male patient suffering from hemophilia A was being monitored by our department due to knee effusions. Extensive knee flexion contracture of the left knee was seen. The Ilizarov technique was chosen for surgical management of the worsening knee flexion contracture. The duration of distraction was six weeks. Due to localized pain and functional impairment, intra-articular administration of platelet-rich plasma (PRP) was applied twice, on the first month after the circular frame removal and at a six-month follow-up, with clinical and functional improvement. Our clinical case report demonstrates that PRP intra-articular injections are likely to provide an improvement in pain and knee joint function, as well as joint hyperemia, even in the case of already established knee flexion contracture, which was managed with a circular distraction device. However, more studies regarding the Ilizarov technique and the PRP intraarticular administration are needed for a protocol to be established for the management of the hemophilic knee joint in the pediatric population.

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Intra-articular injection of platelet-rich plasma in patients with hemophilia and painful knee joint cartilage degeneration

Cited by 2 publications

References 90 publications

Haemophilic arthropathy: Diagnosis, management, and aging patient considerations

Haemophilic arthropathy: Diagnosis, management, and aging patient considerations

Pediatric Hemophilic Arthropathy of the Knee: Treatment With Circular External Fixator and Intra-articular Injection of Platelet-Rich Plasma

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