Intra-articular hyaluronic acid after knee arthroscopy: a two-year study

Hempfling, H.

doi:10.1007/s00167-006-0260-1

Cited by 65 publications

(66 citation statements)

References 16 publications

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“…The role of HA supplementation in restoring a favorable intraarticular milieu after arthroscopic procedures has been an area of particular interest. Hempfling39 noted improved outcomes in pain relief and restoration of function among patients who received HA injection following knee arthroscopy. A number of recent clinical and animal studies have focused on the potential role for viscosupplementation after a number of arthroscopic procedures, including meniscal repair,40,41 ACL reconstruction,42 and treatment of osteochondral defects 43,44…”

Section: Future Directionsmentioning

confidence: 99%

Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

McArthur¹,

Dy²,

Fabricant³

et al. 2012

PPA

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The increasing prevalence of painful knee osteoarthritis has created an additional demand for pharmacologic management to prevent or delay surgical management. Viscosupplementation, via intraarticular injection of hyaluronic acid (HA), aims to restore the favorable milieu present in the nonarthritic joint. The safety profile of intraarticular HA injections for painful knee osteoarthritis is well established, with the most common adverse effect being a self-limited reaction at the injection site. Although acceptance of the early literature has been limited by publication bias and poor study quality, more recent and rigorous meta-analysis suggests that intraarticular HA injection is superior to placebo injection for pain relief and matches, if not surpasses, the effect size of other nonoperative treatments, such as nonsteroidal anti-inflammatory medication. Intraarticular HA injection is effective in providing temporary pain relief in patients with painful knee osteoarthritis. Future investigations should focus on optimizing the composition and administration of HA agents to provide prolonged relief of painful osteoarthritis in the knee and other joints.

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Section: Future Directionsmentioning

confidence: 99%

Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

McArthur¹,

Dy²,

Fabricant³

et al. 2012

PPA

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“…The knee muscle strength index and patient visual analog scale (VAS) pain scores were statistically better in the VIS group. Hempfling reported the results of a level I study in 80 patients undergoing arthroscopic joint lavage with and without hyaluronan postoperatively [Hempfling, 2007]. Both the control and the study groups had positive effects at 3 months, but the treatment effect was maintained in the VIS group for up to 1 year.…”

Section: Clinical Effects Of Hyaluronanmentioning

confidence: 99%

“…Marshall et al [1996] Meta-analysis 68% with severe OA did not progress to TKA S/P tx Chen et al [2002] Level I study: hyaluronan S/P scope VAS scores increased in hyaluronan patients Dai et al [2002] Level I study: hyaluronan S/P scope VAS scores increased in control group Rolf et al [2005] Level I study: hyaluronan vs placebo Improved with hyaluronan and hylan Mathies [2006] Viscoseal S/P meniscectomy Decreased effusion and pain Hempfling [2007] Level I study: hyaluronan vs control Decreased pain up to 1 year Ulucay et al [2007] Level I study: hylan G-F 20, Orthovisc, Adant, and S/P scope …”

Section: Studymentioning

confidence: 99%

Viscosupplementation with hylan G-F 20 in patients with osteoarthrosis of the knee

Bert

Waddell²

2010

Therapeutic Advances in Musculoskeletal

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Viscosupplementation (VIS) is one of several treatment modalities for osteoarthritis of the knee. It is useful in the treatment of osteoarthritis when other methods of conservative care have failed and it may be a safer method of treatment than oral chemical therapy which can have significant side effects with even short-term usage. The biochemical effects of hyaluronic acid are incompletely understood, however there are several accepted modes of action which result in a positive clinical effect on the function of the knee joint. There is some evidence that hyaluronic acid preparations with a higher molecular weight may be more beneficial to the patient. It is commonly used after arthroscopic meniscectomy and or debridement of the knee in a patient with chondral disease. The clinical effects have been well documented in multiple studies in patients with mild to moderate osteoarthritis in study groups before or after arthroscopic surgery of the knee. Adverse events do occur and are easily treated with only rare case reports of systemic effects. Furthermore, there is some evidence that VIS can prolong the need for total knee arthroplasty in the older patient as well.

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“…5 Since then, hyaluronic acid viscosupplementation has become one of the more popular nonoperative treatment options for symptomatic osteoarthritis. [6][7][8] More recently, in 2008, the Osteoarthritis Research Society International (OARSI) cited intra-articular hyaluronic acid as a useful therapeutic modality, that has delayed onset, but prolonged duration of symptomatic benefit, in treating patients with osteoarthritis of the knee or hip. 4 In addition, although marketed as analgesics, viscosupplements have been postulated to have potential chondroprotective effects as well.…”

Section: Introductionmentioning

confidence: 99%

Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20

Conduah

Baker

2009

JPR

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The use of intra-articular viscosupplementation in the nonoperative management of patients with osteoarthritis has become quite popular. Recent clinical data have demonstrated that the anti-inflammatory and chondroprotective actions of hyaluronic acid viscosupplementation reduce pain while improving patient function. We review the basic science and development of viscosupplementation and discuss the mounting evidence in support of the efficacy and safety profile of hylan G-F 20. Recent evidence suggesting a disease-modifying effect of hylan G-F 20 is also assessed. Furthermore, although the primary focus of this article is on treatment of osteoarthritis of the knee, we also discuss the use of viscosupplementation in other joints, such as the hip, ankle, and shoulder.

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Intra-articular hyaluronic acid after knee arthroscopy: a two-year study

Abstract: Arthroscopic knee joint lavage is used when conservative treatment of knee osteoarthritis is unsatisfactory and a joint prosthesis is not yet indicated. The potentially negative effect of irrigation fluids on cartilage metabolism and structure has led to the

Cited by 65 publications

References 16 publications

Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

Viscosupplementation with hylan G-F 20 in patients with osteoarthrosis of the knee

Managing joint pain in osteoarthritis: safety and efficacy of hylan G-F 20

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