Intra-articular administration of purified autologous adipose tissue for knee osteoarthritis treatment

Safety and efficacy of intra-articular infiltration of purified autologous adipose tissue for osteoarthritis treatment: a pre-post study

“…In this analysis, the treatment is effective up until nine months. This improvement could last even longer, as reported in other studies [13, 14], but further research should be performed to confirm it.…”

“…Several studies indicate that intra-articular administration of purified autologous micro-fragmented adipose tissue is a safe and effective treatment for improving knee OA symptoms [12][13][14][15]. However, it is an emerging topic, and all reports about the safety and performance of this novel treatment are pivotal.…”

“…Adipose-derived MSCs (AD-MSCs) can be obtained by using medical devices that comply with minimal manipulation requirements set by European and United States regulatory agencies, and many authors have demonstrated their safety and efficacy [12][13][14][15]. However, most of these studies did not include patients with the most advanced grade of knee OA (i.e., grade IV of the Kellgren-Lawrence classification [16]) or only included a small number of them.…”

Short-term results of intra-articular injections of stromal vascular fraction for early knee osteoarthritis

“…These results are in accordance with other similar studies. For example, Castellarin et al [ 4 ] reported good functional and clinical results after 1 year on 92 patients using the same harvesting device. Adriani et al [ 24 ] reviewed 30 patients who received an autologous percutaneous fat injection for the treatment of KOA.…”

“…Hyaluronic acid (HA) injections are a repeatable option which may reduce pain, but HA does not reverse or repair the damaged cartilage [ 3 ]. Effectiveness of microfractures (MF), autologous chondrocyte implantation (ACI) or matrix-applied chondrocyte implantation (MACI), and autologous chondrocyte transplantation (ACT) in the management of OA is uncertain and unpredictable, suggesting benefits especially in the treatment of focal chondropathies [ 4 – 6 ]. In younger patients with medial compartmental osteoarthritis of the knee, valgus high tibial osteotomy reduces pain and improves knee function [ 7 ].…”