Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium

Yao, Qingping; Wang, S; Gambotto, Andrea; Evans, Christopher H.; Robbins, Paul D.; Ghivizzani, Steven C.; Oligino, Thomas

doi:10.1038/sj.gt.3301881

Cited by 62 publications

(40 citation statements)

References 26 publications

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“…Primary synovial cells from patients with rheumatoid arthritis succumb to TRAIL-mediated apoptosis if infected with a TRAILexpressing vector (5). The study by Liu et al (9) does not address the localization of the infused modified DCs, although there is no doubt that these cells trafficked though the lymphoid organs and the inflamed tissues.…”

Section: Can Trail-expressing Dcs Be Used In the Treatment Of Rheumatmentioning

confidence: 98%

“…As predicted, blockade of TRAIL with soluble DR5 administered systemically exacerbates arthritis, whereas direct transfer of a nonreplicative adenovirus expressing TRAIL into the joints of arthritic mice reduces arthritis (4). Injection of a TRAILexpressing adenovirus into IL-1β-induced arthritic joints also significantly limits synovial proliferation (5).…”

Section: Trail Suppresses the Development Of Arthritismentioning

confidence: 99%

See 1 more Smart Citation

The TRAIL to arthritis

Tsokos¹,

Tsokos²

2003

J. Clin. Invest.

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Section: Can Trail-expressing Dcs Be Used In the Treatment Of Rheumatmentioning

confidence: 98%

Section: Trail Suppresses the Development Of Arthritismentioning

confidence: 99%

The TRAIL to arthritis

Tsokos¹,

Tsokos²

2003

J. Clin. Invest.

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“…This finding has led the emergence of the idea that TRAIL is a potent inhibitor for autoimmune arthritis, promoting studies investigating TRAIL and TRAIL-R in RA (17)(18)(19)(20). Although sTRAIL has less potential activity No correlation was detected between leukocyte and lymphocyte counts, ESR, CRP value and plasma sTRAIL levels of the RA and control groups.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Plasma sTRAIL Level and Disease Activity in Rheumatoid Arthritis

Erbasan¹,

Yazısız²,

Kahraman³

et al. 2017

Akd Med J

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“…TRAIL-deficient mice are hypersensitive to CIA and streptozotocin-induced diabetes and develop heightened autoimmune responses (37). Chronic blockade of TRAIL in mice with soluble DR5 exacerbated autoimmune arthritis, and intraarticular TRAIL gene transfer ameliorated the disease (38,39). In vivo, TRAIL blockade led to profound hyperproliferation of synovial cells and arthritogenic lymphocytes and heightened the production of cytokines and autoantibodies.…”

Section: Cii-dc-adtrail Cell Gene Therapy Inhibits Infiltration Of CImentioning

confidence: 99%

CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis

Liu¹,

Xu²,

Hsu³

et al. 2003

J. Clin. Invest.

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Previously, we described an APC-adenovirus (APC-Ad) FasL cell gene therapy method which could be used to deplete autoreactive T cells in vivo. FasL was toxic, however, and controlled regulation of FasL was not achieved. Here we describe an improved approach to delivering TNF-related apoptosis-inducing ligand (TRAIL) in vivo in which collagen II-induced (CII-induced) arthritis-susceptible (CIA-susceptible) DBA/1j mice were treated with CII-pulsed DCs that had been transfected with a novel Ad system. The Ad was engineered to exhibit inducible TRAIL under the control of the doxycycline-inducible (DOX-inducible) tetracycline response element (TRE). Four groups of mice were treated with CII-DCAdTRAIL+DOX, CII-DC-AdTRAIL (no DOX), CII-DC-AdGFP+DOX, or DC-AdTRAIL+DOX (no CII), beginning 2 weeks after priming with CII in CFA. The incidence of arthritis and infiltration of T cells in the joint was significantly decreased in CII-DC-AdTRAIL+DOX-treated mice. The in vitro splenic T cell proliferative response and induction of IFN-γ to bovine CII stimulation were also significantly reduced in mice treated with CII-DC-AdTRAIL+DOX. AdTRAIL+DOX was not toxic to DCs or mice but could induce activated T cells to undergo apoptosis in the spleen. Our results suggest that CII-DCAdTRAIL+DOX cell gene therapy is a safe and effective method for inhibiting the development of CIA.

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Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium

Cited by 62 publications

References 26 publications

The TRAIL to arthritis

The TRAIL to arthritis

The Relationship between Plasma sTRAIL Level and Disease Activity in Rheumatoid Arthritis

CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis

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