Intra-Arterial Treatment with <sup>90</sup>Yttrium Microspheres in Treatment-Refractory and Unresectable Liver Metastases of Neuroendocrine Tumors and the Use of <sup>111</sup>In-Octreotide Scintigraphy in the Evaluation of Treatment Response

Lacin, Seda; Öz, İlker; Özkan, Elgin; Küçük, Ömer; Bilgiç, Sadık

doi:10.1089/cbr.2011.0957

Cited by 16 publications

(7 citation statements)

References 13 publications

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“…Of these 36 studies, four studies were subsequently excluded based on overlapping enrollment dates at the same centers and similar patient numbers [4,25,28,34]. In each case of suspected overlapping enrollments, the largest study from each center was retained, ultimately leaving 32 observational studies with 34 study arms for analysis [24,26,27,[29][30][31][32][33].…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis

Pollock

Brennan²,

Peters³

et al. 2020

Expert Review of Anticancer Therapy

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Objectives: Neuroendocrine tumors (NETs) are a heterogeneous group of cancers arising from neuroendocrine cells. The aim was to evaluate objective response rate (ORR) as a predictor of overall survival (OS) in patients with metastatic NETs (mNETs) treated with radioembolization (RE). Methods: Randomized controlled trials and observational studies of RE treatment of mNETs were identified by systematic literature review (SLR). Pooled ORR and OS estimates were calculated and a weighted generalized linear model (GLM) of ORR as a predictor of OS was derived, stratified by ORR assessment criteria and RE type (Yttrium-90 resin or glass microspheres). Results: The SLR identified 32 observational studies. Mean ORR was 41% (95% confidence interval 38-45%). The Yttrium-90 resin and glass microsphere GLMs accounted for 59% and 57% of OS deviance, respectively. ORR was a significant predictor of OS in the resin microspheres model (p < 0.001), but not the glass microspheres model (p = 0.11). Conclusions: A weighted GLM showed a significant relationship between ORR and OS in patients with mNETs treated with Yttrium-90 resin microspheres. ORR could therefore potentially be an OS surrogate in future trials of Yttrium-90 resin microspheres. Further research is needed to confirm the relationship between ORR and OS and the difference between resin and glass microspheres.

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Section: Systematic Literature Reviewmentioning

confidence: 99%

Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis

Pollock

Brennan²,

Peters³

et al. 2020

Expert Review of Anticancer Therapy

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“…Application of the selection criteria narrowed down the selection to 12 studies (10,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Most studies were excluded because they did not provide separate and complete Response Evaluation Criteria in Solid Tumors (RECIST) data specifically on hepatic mNETs treated with radioembolization.…”

Section: Studies Selected and Critical Appraisalmentioning

confidence: 99%

The Efficacy of Hepatic ⁹⁰Y Resin Radioembolization for Metastatic Neuroendocrine Tumors: A Meta-Analysis

et al. 2014

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90 Y resin radioembolization is an emerging treatment in patients with liver-dominant metastatic neuroendocrine tumors (mNETs), despite the absence of level I data. The aim of this study was to evaluate the efficacy of this modality in a meta-analysis of the published literature. Methods: A comprehensive review protocol screened all reports in the literature. Strict selection criteria were applied to ensure consistency among the selected studies: human subjects, complete response data with time interval, resin microspheres, more than 5 patients, not a duplicate cohort, English language, and separate and complete data for resin-based 90 Y treatment of mNET if the study included multiple tumor and microsphere types. Selected studies were critically appraised on 50 study criteria, in accordance with the research reporting standards for radioembolization. Response data (Response Evaluation Criteria in Solid Tumors) were extracted and analyzed using both fixed and random-effects meta-analyses. Results: One hundred fifty-six studies were screened; 12 were selected, totaling 435 procedures for response assessment. Funnel plots showed no evidence of publication bias (P 5 0.841). Critical appraisal revealed a median of 75% of desired criteria included in selected studies. Very high between-study heterogeneity ruled out a fixed-effects model. The random-effects weighted average objective response rate (complete and partial responses, CR and PR, respectively) was 50% (95% confidence interval, 38%-62%), and weighted average disease control rate (CR, PR, and stable disease) was 86% (95% confidence interval, 78%-92%). The percentage of patients with pancreatic mNET was marginally associated with poorer response (P 5 0.030), accounting for approximately 23% of the heterogeneity among studies. The percentage of CR and PR correlated with median survival (R 5 0.85; P 5 0.008). Conclusion: This meta-analysis confirms radioembolization to be an effective treatment option for patients with hepatic mNET. The pooled data demonstrated a high response rate and improved survival for patients responding to therapy.

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“…Five-year survival rates have been reported between 30%-50%[ 138 ]. Radioembolization using 90 Yttrium (90Y) microspheres is another liver-directed treatment method, with a response rate of 32% and improvement in symptoms in 50% of patients[ 139 , 140 ].…”

Section: Types Of Gi Netsmentioning

confidence: 99%

Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours

Yozgat¹,

Kekilli²,

Altay³

2021

WJCC

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Neuroendocrine tumors (NETs) are a rare and heterogeneous disease group and constitute 0.5% of all malignancies. The annual incidence of NETs is increasing worldwide. The reason for the increase in the incidence of NETs is the detection of benign lesions, incidental detection due to the highest use of endoscopic and imaging procedures, and higher recognition rates of pathologists. There have been exciting developments regarding NET biology in recent years. Among these, first of all, somatostatin receptors and downstream pathways in neuroendocrine cells have been found to be important regulatory mechanisms for protein synthesis, hormone secretion, and proliferation. Subsequently, activation of the mammalian target of rapamycin pathway was found to be an important mechanism in angiogenesis and tumor survival and cell metabolism. Finally, the importance of proangiogenic factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblastic growth factor, angiopoietin, and semaphorins) in the progression of NET has been determined. Using the combination of biomarkers and imaging methods allows early evaluation of the appropriateness of treatment and response to treatment.

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Intra-Arterial Treatment with ⁹⁰Yttrium Microspheres in Treatment-Refractory and Unresectable Liver Metastases of Neuroendocrine Tumors and the Use of ¹¹¹In-Octreotide Scintigraphy in the Evaluation of Treatment Response

Cited by 16 publications

References 13 publications

Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis

Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis

The Efficacy of Hepatic ⁹⁰Y Resin Radioembolization for Metastatic Neuroendocrine Tumors: A Meta-Analysis

Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours

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Intra-Arterial Treatment with 90Yttrium Microspheres in Treatment-Refractory and Unresectable Liver Metastases of Neuroendocrine Tumors and the Use of 111In-Octreotide Scintigraphy in the Evaluation of Treatment Response

Cited by 16 publications

References 13 publications

Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis

Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis

The Efficacy of Hepatic 90Y Resin Radioembolization for Metastatic Neuroendocrine Tumors: A Meta-Analysis

Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours

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Product

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Intra-Arterial Treatment with ⁹⁰Yttrium Microspheres in Treatment-Refractory and Unresectable Liver Metastases of Neuroendocrine Tumors and the Use of ¹¹¹In-Octreotide Scintigraphy in the Evaluation of Treatment Response

The Efficacy of Hepatic ⁹⁰Y Resin Radioembolization for Metastatic Neuroendocrine Tumors: A Meta-Analysis