Intra-arterial methotrexate chemotherapy and telecobalt therapy in cancer of the oral cavity and oropharynx

Abstract

This paper presents the results of a controlled therapeutic trial comparing the combination of intra‐arterial infusion chemotherapy and radiotherapy with radiotherapy alone in advanced (T4) cancers of the oral cavity and oropharynx. Tumor regression was far greater with the combination treatment: 40% compared to 10% with radiotherapy alone. The median survival rate was 6 months in the group receiving radiotherapy alone, and 9 months in those receiving the combination. While recognizing the importance of the treatment, the authors realize the necessity of continued investigation into different combination possibilities in order to obtain better survival results.

Interventional Management of Head and Neck Tumors

“…66 First trial comparing IA chemotherapy to radiation treatment was conducted in 1965 at the Institut Gustave-Roussy. 67 Various investigators have since studied IA use of various chemotherapeutic agents including methotrexate, 5-fluorouracil, bleomycin, mitomycin-C, and cisplatin. 65 These studies conducted primarily in European, Japanese, and North American centers have shown IA administration of cisplatin, in conjunction with simultaneous intravenous sodium thiosulfate infusion (to neutralize cisplatin toxicity), to be the most effective chemotherapeutic agent for the chemoradiation treatment of head and neck tumors.…”

Review of the possibilities of regional intra-arterial chemotherapy in the treatment of squamous cell carcinoma of the nasal cavity and paranasal sinuses

“…Первая работа, посвященная оценке эффективности интраартериальной ПХТ, была выполнена еще в 1965 г. в Институте Гюстава Русси во Франции. Авторы сравнивали эффективность лучевой терапии в монорежиме и в комбинации с интраартериальной ХТ при раке слизистой оболочки полости рта и ротоглотки [11]. В 2000 г. были представлены результаты крупного исследования RADPLAT, проведенного в Университете Теннесси (Мемфис, США) с 1993 по 1998 г. В исследование были включены 213 пациентов с III и IV стадиями плоскоклеточного рака головы и шеи.…”

Induction chemotherapy for squamous cell carcinomas of the oral cavity: A cumulative meta-analysis

“…Nine studies originated from establishments in France, six from the United States of America, three from Italy, and one each from Australia, Argentina, Brazil, Sweden, Germany Japan, China, India, and Thailand. The earliest trial started recruitment in 1965 18 whilst the most recent completed recruitment in 2008 19 . 1484 participants were pooled in the ICT group whereas the control group had 1388 patients for the metaanalysis.…”

“…1484 participants were pooled in the ICT group whereas the control group had 1388 patients for the metaanalysis. 14 RCTs compared the addition of ICT to surgery with/without radiotherapy [20][21][22][23][24][25][26][27][28][29][30][31][32][33] , 10 against radiotherapy alone 18,25,26,[33][34][35][36][37][38][39] , one for CCRT 19 , and one study 40 did not specify the standard therapy given. Regarding ICT regimen, twelve trials evaluated a Cisplatin-5-Fluorouracil containing protocol 20,21,25,26,32,[36][37][38][40][41][42] , eight used a Cisplatin-Bleomycin containing protocol 22, 24,28,33,34,36,38,39 , two administered Bleomycin and Vinicristine 23,27 , one included Cisplatin, Bleomycin and 5-Fluorouracil (5-FU)…”