Intra-arterial infusion chemotherapy as a preoperative treatment of locally advanced breast cancer

Abstract

Intra-arterial infusion chemotherapy was made through the internal mammary artery and subclavian artery in 12 cases of locally advanced breast cancer. Continuous infusion of 5-fluorouracil and intermittent injections of Mitomycin C were jointly made for 1 to 4 weeks in each artery. Marked response in not only the primary tumor but also lymph node metastasis was clinically observed, permitting extended radical mastectomy successfully in all cases. Remarkable regressive changes were histologically observed in cancer foci, especially in small ones, of resected specimens including axillary, parasternal, and supraclavicular lymph nodes. All cases except 1 have been healthy without any recurrence for 22 to 78 months after treatment. Intra-arterial infusion chemotherapy will this method is a useful preliminary procedure for surgical treatment of locally advanced breast cancer.

Clinical efficacy and value of redistributed subclavian arterial infusion chemotherapy for locally advanced breast cancer

“…1,2 Arterial infusion chemotherapy is not a standard therapy, but it is sometimes performed with the aim of down-staging or for local control. There are some reports of arterial infusion chemotherapy [3][4][5][6][7][8][9][10] and a catheter port system, 11 which as neoadjuvant chemotherapy attained high local control (70%-90%).…”

Therapy possibilities for locoregional recurrences in breast cancer

“…Bereits in den 60 er Jahren wurde dieses Therapieprinzip erstmals eingesetzt [16], wobei diese und weitere Studien eine 50-bis 80 %ige Remissionsrate bei inoperablen thera-pierefraktären Mammakarzinomrezidiven angeben [8,11,17]. B. bei supraklavikulären oder fortgeschrittenen axillären Lymphknotenrezidiven oder nicht gegebener Narkosefähigkeit kann mit dem Ziel einer hohen lokalen Zytostatikakonzentration über Sondierung der Tumorgefäûe durch intraarterielle Katheter eine lokoregionäre Chemotherapie appliziert werden.…”

Histological Evaluation of the Effects of Intraarterial Chemotherapy for Advanced Breast Cancer: A Long-term Followup Study with Respect to the Survival Rate

“…6 For IAIC, essentially two regimens were used, according to the period of this treatment. 6 For IAIC, essentially two regimens were used, according to the period of this treatment.…”

“…The dose intensity of neoadjuvant chemotherapy and its administration schedule also remain controversial. [5][6][7][8] The purpose of the present study is thus to examine the efficacy of neoadjuvant chemotherapy using IAIC for advanced breast cancer, and to contribute to the identification of the histological response in order to better predict the survival time of Stage III and IV patients. Several reports were published in the 1960s on this procedure, and many comprehensive studies have claimed prominent responses in locoregional lesions and/or long-term survival times after surgery of breast cancer.…”