Intra-arterial Chemotherapy with Cisplatin Followed by Radical Radiotherapy for Locally Advanced Cervical Cancer

Sueyama, Hiroo; Nakano, Masao; Sakumoto, Kaoru; Toita, Takafumi; Takizawa, Yoshikazu; Moromizato, Hidekazu; Kakihana, Yasumasa; Kushi, Akira; Moromizato, Hidehiko; Higashi, Masahiro; Kanazawa, Kazuki

doi:10.1006/gyno.1995.9968

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…These findings must be reevaluated, however, because in recent years gynecologists are increasingly using combined chemotherapy with irradiation after surgery, which has so far proved to be effective [1,2]. As a result, the dose of radiation can be expected to further decrease.…”

Section: Discussionmentioning

confidence: 90%

“…Another striking result of the proportional hazard model was that larger doses of internal radiation significantly reduce the risk of death after irradiation, whereas the doses of external radiation do not. These findings must be reevaluated, however, because in recent years gynecologists are increasingly using combined chemotherapy with irradiation after surgery, which has so far proved to be effective [1,2]. As a result, the dose of radiation can be expected to further decrease.…”

Section: Discussionmentioning

confidence: 99%

“…In the former group, 5 of 18 patients died of bleeding from the remaining intestine after operation. We concluded that surgical resection of the diseased intestine is a useful procedure for treating radiation enterocolitis to reduce intestinal bleeding from the irradiated intestine.Radiation enterocolitis often results from radiotherapy, which is used for the treatment of various gynecologic malignancies in combination with other therapeutic modalities such as chemotherapy or surgery [1,2]. In the worst cases, patients require surgery because of intestinal obstruction or bleeding.…”

mentioning

confidence: 99%

“…Radiation enterocolitis often results from radiotherapy, which is used for the treatment of various gynecologic malignancies in combination with other therapeutic modalities such as chemotherapy or surgery [1,2]. In the worst cases, patients require surgery because of intestinal obstruction or bleeding.…”

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confidence: 99%

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Radiation Enterocolitis: Overview of the Past 15 Years

et al. 1998

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From April 1980 to April 1995 a total of 54 patients (53 women, 1 man) were hospitalized in our department for the surgical treatment of radiation enterocolitis. Two surgical protocols were applied for these patients: intestinal decompression procedures alone (intestinal bypass, colostomy, or both; n = 18) or an intestinal resection in addition to decompression (n = 36). The clinical factors contributing to survival after irradiation were retrospectively reviewed by a multiple variate proportional hazards model. As a result, patients treated with decompression procedures alone had an 11 times higher risk for death than those treated with the addition of intestinal resection. In the former group, 5 of 18 patients died of bleeding from the remaining intestine after operation. We concluded that surgical resection of the diseased intestine is a useful procedure for treating radiation enterocolitis to reduce intestinal bleeding from the irradiated intestine.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Radiation Enterocolitis: Overview of the Past 15 Years

et al. 1998

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“…Thus, the addition of chemotherapy in the treatment of advanced cervical cancer has improved the survival by controlling both the primary lesion and the distant metastases. Previously, neoadjuvant chemotherapy with a platinum-based regimen for operable cervical cancer yielded high response rates, ranging from 40 to 82% (23)(24)(25). In this experiment, the antitumor activity of TS-1 was excellent, and Table III.…”

Section: Discussionmentioning

confidence: 73%

Preclinical analysis of the antitumor efficacy of TS-1 using human uterine cervical cancer tumor xenografts

Nagai¹

1994

Oncol Rep

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Abstract. We investigated the antitumor activity of TS-1 in comparison with that of UFT and cisplatin (CDDP) against cervical cancer using xenografts of a human uterine cervical squamous cell cancer cell line, CaSki, transplanted into female Balb/cA JcL-nu mice. CaSki cell xenografts were prepared by subcutaneous (s.c.) implantation of 3x10 6 cells/animal into the right dorsal region of the mice. The tumor volume was measured twice a week and the relative tumor volume (RTV) was calculated. We divided the animals into four groups according to the treatment administered; TS-1 (10 mg/kg orally, once daily for 14 consecutive days), UFT (24 mg/kg orally, once daily for 14 consecutive days), CDDP (7.6 mg/kg injected intravenously once on the 1st day) and control (no treatment) groups. The antitumor effects of the drugs were measured. On the 35th day after the completion of treatment, the mean tumor volume in the mice treated with TS-1 or CDDP changed from 132.873±11.783 mm 3 to 706.401± 613.122 mm 3 and 133.809±19.366 mm 3 to 722.630±855.509 mm 3 , respectively. The mean tumor volume in the groups treated with TS-1 or CDDP was significantly lower compared to that in the control group (p<0.001; one-tailed Student's t-test). The relative inhibition of the tumor growth was 65.31 in the TS-1 group, 48.31 in the UFT group and 64.51 in the CDDP group. We conclude that TS-1 administered orally for 14 consecutive days showed the highest antitumor activity.

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