Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Abstract

Advancing our understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression, and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this novel catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing, and for identifying high-risk biological and structural coronary arterial plaques in vivo.

Intravascular optical coherence tomography [Invited]

“…Combining detection of fluorescence with OCT in a multimodal intravascular catheter (Fig. 16) has also been demonstrated, complementing the structural OCT signal with true molecular information [120][121][122][123]. These catheters employ a dual clad fiber to collect fluorescence through the inner cladding while operating OCT through the single mode core of the fiber.…”

Current Clinical Applications of Intravascular Optical Coherence Tomography in Coronary Artery Disease

“…The 3D navigation menu supports functions to move throughout the 3D rendering and object segmentation to turn on and off the displayed 3D objects including tissue, lumen, stent, wires, and side branches. (16,17).…”

Clinical Applications of Intracoronary OCT (Invited Paper)

“…7). [21][22][23][24] . 또한, CT FFR처럼 OCT lumen contour를 추 출하여 만들어진 3차원 혈관 영상으로부터 전산유체역학 (CFD, computational flow dynamics) 모의시험을 통한 생리 기능적 정보인 sheer stress와 [25] …”