Intra-aortic prostaglandin E1 infusion in maturation of neuroblastoma

Imashuku, Shinsaku; Sugano, Tomoko; Fujiwara, Kazuhito; Todo, Shinjiro; Ogita, Shuhei; Goto, Yudai

doi:10.1007/bf01953660

Cited by 9 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That cAMP was involved in cell growth and differentiation became clear beginning in 1971 when two simultaneous reports of studies with cultured mammalian cells demonstrated an effect of this substance on inducing phenotypic maturation (136,137). Since then, substantial experimental evidence has been accumulated implicating alterations in cyclic nucleotide regulatory mechanisms as being important in the process of differentiation (76 (140,141). In some reports, apparent beneficial results were claimed as a result of promoting in vivo maturation of cancer cells (140,141).…”

Section: Cyclic Amp Systemmentioning

confidence: 99%

“…Since then, substantial experimental evidence has been accumulated implicating alterations in cyclic nucleotide regulatory mechanisms as being important in the process of differentiation (76 (140,141). In some reports, apparent beneficial results were claimed as a result of promoting in vivo maturation of cancer cells (140,141). However, these cases lacked objective standards of evaluation and to date no rigorous trials have been published.…”

Section: Cyclic Amp Systemmentioning

confidence: 99%

See 1 more Smart Citation

Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiation.

Abemayor¹,

Sidell²

1989

Environ Health Perspect

143

View full text Add to dashboard Cite

Neuroblastoma is a childhood solid tumor composed of primitive cells derived from precursors of the autonomic nervous system. This neoplasm has the highest rate of spontaneous regression of all cancer types and has been noted to undergo spontaneous and chemically induced differentiation into elements resembling mature nervous tissue. As such, neuroblastoma has been a prime model system for the study of neuronal differentiation and the process of cancer cell maturation. In this paper we review those agents that have been described to induce the differentiation of neuroblastoma, with an emphasis on the effects and possible mechanisms of action of a group of related compounds, the retinoids. With this model system and the availability of subclones that are both responsive and resistant to chemically induced differentiation, fundamental questions regarding the mechanisms and processes underlying cell maturation have become more amenable to in vitro study.

show abstract

Section: Cyclic Amp Systemmentioning

confidence: 99%

Section: Cyclic Amp Systemmentioning

confidence: 99%

Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiation.

Abemayor¹,

Sidell²

1989

Environ Health Perspect

143

View full text Add to dashboard Cite

show abstract

“…With some human neuroblastoma cell lines, an increase in neurite extension and reduced growth rate can be demonstrated when cAMP derivatives, agents that activate adenylate cyclase or inhibit phosphodiesterase, are administered singly or in combination (138,139). These observations, along with dramatic phenotyic changes seen with murine neuroblastoma cells (138), have prompted limited application of cAMP-elevating agents for the treatment of this disease (140,141). In some reports, apparent beneficial results were claimed as a result of promoting in vivo maturation of cancer cells (140,141).…”

Section: Cyclic Amp Systemmentioning

confidence: 99%

“…These observations, along with dramatic phenotyic changes seen with murine neuroblastoma cells (138), have prompted limited application of cAMP-elevating agents for the treatment of this disease (140,141). In some reports, apparent beneficial results were claimed as a result of promoting in vivo maturation of cancer cells (140,141). However, these cases lacked objective standards of evaluation and to date no rigorous trials have been published.…”

Section: Cyclic Amp Systemmentioning

confidence: 99%

Human Neuroblastoma Cell Lines as Models for the In Vitro Study of Neoplastic and Neuronal Cell Differentiation

Abemayor¹,

Sidell²

1989

Environmental Health Perspectives

View full text Add to dashboard Cite

show abstract

Human Medullary Thyroid Carcinoma: Initial Characterization and In Vitro Differentiation of Two New Cell Lines

Abemayor¹,

Sidell²,

Juillard³

1989

Archives of Otolaryngology - Head and Neck Surgery

View full text Add to dashboard Cite

of the thyroid (MCT), a tumor of calcitonin (CT)\p=m-\secret-ing C cells, can display a variable malignant potential with poor prognosis linked to decreased cell differentiation. In vitro study of MCT has been hampered by the fact that few cell lines derived from this neoplasm have been available for study. Herein are reported the characteristics of two new lines derived from human MCT that are tumorigenic in athymic mice and do not secrete CT. After treatment with various concentrations of retinoic acid (a vitamin A derivative) and cyclic adenosine monophosphate, both lines exhibit the traits of more differentiated cells with a decrease in cellular proliferation and an increase in cytoplasmic CT content as shown by in situ immunoperoxidase staining. These cell lines should prove of great value in the study of the biology of MCT and the mechanisms underlying induced differentiation in this type of tumor.In 1959, Hazard et al1 proposed the designation of medullary carcino¬ ma of the thyroid (MCT) for a solid, nonfollicular tumor characterized by high amounts of stromal amyloid and a proclivity for lymph node métasta¬ ses. This neoplasm accounts for approximately 5% to 12% of all thy¬ roid tumors and is one component of the multiple endocrine neoplasia type 2 syndrome, which consists of tumors of the thyroid, adrenal medulla, and parathyroid. Two forms of this syn¬ drome are recognized, a sporadic, nonheritable type as well as a familial form that is inherited as an autosomal dominant trait. The natural history of treated MCT reveals it to be potential¬ ly aggressive, with a ten-year survival rate of 50% to 67%. The tumor's ulti¬ mate behavior is influenced by the type of initial treatment, anatomic location, and chronologic age at recur¬ rence.23Williams4 in 1966 suggested that MCT arose from the neural crestderived C cells of the thyroid, which synthesize and secrete the hypocalcé¬ mie substance calcitonin (CT). With the advent of radioimmunoassay, it became feasible to examine blood CT levels and utilize these as unique markers for detecting and monitoring disease activity. Following treatment, elevation in CT levels may signify disease recurrence, whereas a drop in CT levels may signal cure or a loss of the tumor's ability to secrete the hor¬ mone; this in turn is associated with a poorer prognosis.3·5 Once MCT metastasizes, it can exhibit aggressive behavior with a poor response to radi¬ ation therapy or chemotherapy. Since conventional therapies appear to have limited efficacy, alternative ap¬ proaches to treating disseminated MCT are needed.As a first approach to studying the biologic behavior of this neoplasm, accessible in vitro models are required. To date, only a limited num¬ ber of short-term cultured cell lines derived from human MCT have been reported.68 Moreover, long-term studies of cells derived from human MCT surgical specimens are ham¬ pered by instability in cell population as judged by time-dependent de¬ creases in medium CT concentra¬ tions.9 The most widely used MCT culture is the TT line fir...

show abstract

Intra-aortic prostaglandin E1 infusion in maturation of neuroblastoma

Cited by 9 publications

References 2 publications

Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiation.

Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiation.

Human Neuroblastoma Cell Lines as Models for the In Vitro Study of Neoplastic and Neuronal Cell Differentiation

Human Medullary Thyroid Carcinoma: Initial Characterization and In Vitro Differentiation of Two New Cell Lines

Contact Info

Product

Resources

About