Intra‐ and interobserver reproducibility of Bruch's membrane opening minimum rim width measurements with spectral domain optical coherence tomography

Reis, Arlete Barbosa dos; Zangalli, Camila; Abe, Ricardo Y.; Silva, André Leandro; Vianna, Jayme R; Vasconcellos, José Paulo Cabral de; Costa, Vital Paulino

doi:10.1111/aos.13464

Cited by 28 publications

(37 citation statements)

References 41 publications

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“…The currently estimated variance for volumes within occasions corresponds to previously published data (Park et al 2017;Reis et al 2017;Schrems-Hoesl et al 2018). Increasing the number of volumes averaged per occasion increases precision in follow-up comparisons within subject.…”

Section: Discussionsupporting

confidence: 60%

“…A previous study reported an increase in within occasion variation when several observers acquired the images (Reis et al. ). On the other hand, another study did not report an increase in within occasion variation when the number of devices operated by different observers increased (Schrems‐Hoesl et al.…”

Section: Discussionmentioning

confidence: 97%

“…For normal and glaucomatous eyes, the variance for measurements of global BMO-MRW, calculated from estimates of within occasion measurement standard deviation, was 9 and 11 lm 2 , respectively (Park et al 2017). For glaucomatous eyes, the intra-and interobserver global BMO-MRW variance was 7 and 23 lm 2 , respectively (Reis et al 2017). For a mix of glaucomatous and normal eyes, variation of global BMO-MRW among Spectralis devices was estimated, as variance, to 3 lm 2 or 1 lm 2 , depending on device mode.…”

Section: Introductionmentioning

confidence: 99%

“…For glaucomatous eyes, the intra‐ and interobserver global BMO‐MRW variance was 7 and 23 μ m 2 , respectively (Reis et al. ). For a mix of glaucomatous and normal eyes, variation of global BMO‐MRW among Spectralis devices was estimated, as variance, to 3 μ m 2 or 1 μ m 2 , depending on device mode.…”

Section: Introductionmentioning

confidence: 99%

“…Commercially available automated algorithms are still under development. Manual review and correction is still required (Enders et al 2017;Park et al 2017;Reis et al 2017;Schrems-Hoesl et al 2018;Tun et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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Purpose To estimate the sources of variation for Pigment epithelium central limit‐Inner limit of the retina Minimal Distance averaged over 2π (PIMD‐2π), and further to analyse their consequences for clinical measurements of glaucoma. Methods Forty subjects with early to moderate stage glaucoma were included. Three SD‐OCT volumes of the optic nerve head (ONH) were captured at two occasions. Each volume was segmented three times for PIMD‐2π. The magnitude of the sources of variation for PIMD‐2π measurements was estimated with an analysis of variance. Results A 95% confidence interval for mean PIMD‐2π was estimated to 215 ± 12 μm (df = 38). The estimated variance for subjects was 1280 μm2. The within‐subject estimated variance for occasions, volumes and segmentations was 10 μm2, 30 μm2 and 40 μm2, respectively. The within‐subject variances were used to model follow‐up of PIMD‐2π over time. A linear loss rate of 0.05 of baseline PIMD‐2π/year was assumed. A significant PIMD‐2π change could be detected in approximately 16–18 months with evenly spaced visits every 4 or 6 months. Conclusions Due to the small within‐subject estimated variances, a clinically undesirable PIMD‐2π change from baseline can be detected in approximately 18 months. Detection of significant PIMD‐2π loss in a subject requires knowledge of normal age loss and measurement variability.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width

Mitsch

Stephan

Wassermann

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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Purpose The assessment of cup-disc ratio as a surrogate parameter for the neuroretinal rim width (NRW) of the optic nerve is well established, but prone to human error and imprecision. Objective assessment of the NRW is provided by spectral domain optical coherence tomography (SD-OCT). This study is the first to systematically compare NRW measurements acquired with the Carl Zeiss Meditech Cirrus HD-OCT 5000 and the Heidelberg Engineering Spectralis SD-OCT. Methods In this cross-sectional study, 20 eyes of each 20 glaucoma patients and 20 age-matched healthy controls underwent ophthalmic examination, SD-OCT imaging, and computer perimetry. Regression analyses were performed for the NRW comparability and the effect of the rotational alignment disconcordance (RAD), receiver-operating characteristics (ROC) for NRWbased healthy glaucoma discrimination capability, and Pearson's correlation for covariate association. Results Mean NRW differences were 8 ± 48 μm (p = 0.4528), 91 ± 80 μm (p < 0.01), and 49 ± 77 μm (p < 0.001) in the glaucoma, healthy, and whole group. On average, the Cirrus showed higher NRW values (+ 50 μm) than the Spectralis, this difference increased with values starting with 159 μm. Discrimination ROC were 1.0 (Spectralis) and 0.9675 (Cirrus). RAD showed very little effect on NRW (R 2 = 0.9661, p < 0.001). NRW-covariate correlation was highly significant (p < 0.001) with both devices for clinical cup/disc ratio, calculated rim width, visual field mean, and pattern deviations. Conclusions Our results suggest to only cautiously compare Spectralis and Cirrus NRW measurements only in patients with morphologically manifest glaucoma. For morphological progression analysis, we recommend the continuous usage of the same device.

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Novel area-based optic nerve head parameter to distinguish glaucoma from non-glaucomatous retinal nerve fiber layer defect in branch retinal vein occlusion

Park

2021

Graefes Arch Clin Exp Ophthalmol

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Intra‐ and interobserver reproducibility of Bruch's membrane opening minimum rim width measurements with spectral domain optical coherence tomography

Abstract: The reproducibilities of BMO-MRW, BMO area measurements and FoBMO angle were excellent in both healthy subjects and patients with glaucoma. Bruch's membrane opening minimum rim width (BMO-MRW) reproducibility is comparable to that of RNFLT measurements.

Cited by 28 publications

References 41 publications

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width

Novel area-based optic nerve head parameter to distinguish glaucoma from non-glaucomatous retinal nerve fiber layer defect in branch retinal vein occlusion

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