Intra- and Inter-Rater Agreement of Anterior Lamina Cribrosa Depth Measurements Using Enhanced-Depth Imaging Optical Coherence Tomography

Abstract

Purpose: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). Methods: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point. Two experienced operators performed manual ALCD measurements of the LC independently, and one of the observers performed the same measurements twice. Intra- and inter-rater agreement was evaluated using intraclass correlation coefficients (ICC) and concordance correlation coefficients (CCC) for the right eye vertical (REV) and horizontal (REH) scans and left eye vertical (LEV) and horizontal (LEH) scans. Results: 120 eyes of 61 subjects, with a mean age of 62.1 ± 15.0 years. The mean REV, REH, LEV and LEH ALCD were 456.2 ± 84.3, 444.5 ± 92.2, 436.7 ± 81.6, 427.6 ± 82.7 μm, respectively. ALCD intra- and inter-rater ICC and intra- and inter-rater CCC varied between 0.85-0.95, 0.84-0.93, 0.85-0.95 and 0.84-0.93, respectively. Conclusions: ALCD manual intra- and inter-rater measurements with EDI-OCT showed high agreement. EDI-OCT is a reliable tool for ALCD measurement, which can provide potentially useful information for integrated glaucoma management.

Reliability of Retinal Layer Annotation with a Novel, High-Resolution Optical Coherence Tomography Device: A Comparative Study

“…In line with other publications, we found a disparity between inter- and intra-reader reliability for retinal layer annotations [ 22 , 23 , 24 ]. As expected, these were most pronounced in layers difficult to delineate, such as the outer plexiform layer where graders had to account for the Henle Nerve Fiber dispersion [ 25 ].…”

Relationship between Intraocular Pressure and Anterior Lamina Cribrosa Depth: A Cross-Sectional Observational Study in a Healthy Portuguese Population

“…It is therefore essential to assess agreement measures before interpreting the data presented here. Previous unpublished data from our group had calculated an intraobserver intraclass correlation coefficient of 0.91 and an interobserver intraclass correlation coefficient of 0.90 of ALCD manual measurements using EDI-OCT (21). Calculated intraobserver and interobserver repeatability coefficients are between 10 and 14 μm and 12 and 14 μm, respectively.…”

“…A previous study verified these measurements to be highly reproducible and with a low intraobserver and interobserver variability. Intraobserver and interobserver concordance correlation coefficients varied between 0.85-0.95 and 0.84-0.93, respectively (21).…”