Intra-Accumbal D1- But not D2-Like Dopamine Receptor Antagonism Reverses the Inhibitory Effects of Cannabidiol on Extinction and Reinstatement of Methamphetamine Seeking Behavior in Rats

Identification of the circRNA–miRNA–mRNA network for treating methamphetamine‐induced relapse and behavioral sensitization with cannabidiol

“…We found that repeated administration of CBD (40 mg/kg, but not 20 mg/kg) during the METH withdrawal period significantly inhibits METH‐induced CPP reinstatement and behavioral sensitization in mice. However, in this study, the administration of CBD had no discernible effects on CPP extinction in mice, which differs from our prior investigation as well as other existing studies 13 . Species differences among experimental subjects may be one of the reasons for the observed discrepancies.…”

“…However, in this study, the administration of CBD had no discernible effects on CPP extinction in mice, which differs from our prior investigation as well as other existing studies. 13 Species differences among experimental subjects may be one of the reasons for the observed discrepancies. For instance, administering CBD (40 and 80 mg/kg) for 10 consecutive days during extinction phase facilitated CPP extinction in rats.…”

“…CBD treatment also reduced the motivation of METH self‐administration, drug‐seeking behavior, and METH‐primed relapse in extinguished rats 11,12 . Additionally, CBD administration during the extinction phase or reinstatement phase of METH‐induced CPP in rats facilitated extinction and suppressed the CPP reinstatement 13 . Despite these studies preliminary revealing the positive effects of CBD on METH‐induced relapse, the mechanism for the CBD treatment of METH‐induced relapse is poorly understood.…”

Oxycodone Self-Administration in Female Rats is Enhanced by Δ9-tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure

“…injection. CBD by intraventricular injection, speeds extinction, and attenuates methamphetamine cued re-instatement, of methamphetamine conditioned place preference (Mirmohammadi et al, 2022). There does not appear to be any evidence whether CBD can alter the rewarding value of opioids.…”

“…Although Δ 9 -tetrahydrocannabinol is undoubtedly the cons tuent of cannabis that drives most use, for both recrea onal and therapeu c purposes, addi onal cons tuents may also produce significant effects. Cannabidiol (CBD) reduces alcohol or cocaine seeking behavior in rats when applied via a dermal gel (Gonzalez-Cuevas et al, 2018), as well as cocaine (Galaj et al, 2020) or methamphetamine (Hay et al, 2018) seeking in rats and alcohol seeking in rats (Tringali et al, 2023) (Mirmohammadi et al, 2022). There does not appear to be any evidence whether CBD can alter the rewarding value of opioids.…”