Intra-accumbal administration of AMN082, a metabotropic glutamate receptor type 7 allosteric agonist, inhibits the acquisition but not the expression of morphine-induced conditioned place preference in rats

Vatankhah, Mahsaneh; Karimi‐Haghighi, Saeideh; Sarihi, Abdolrahman; Haghparast, Abbas

doi:10.1016/j.neulet.2018.05.031

Cited by 18 publications

(34 citation statements)

References 20 publications

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“…Previous studies have shown that mGluRs are involved in the acquisition and expression of morphineinduced CPP (5,6). The NAc plays a crucial role in developing physical dependence on morphine (39).…”

Section: Discussionmentioning

confidence: 99%

“…In this apparatus, rats showed no consistent preference for either compartment. The CPP protocol has been previously described (45). An unbiased allocation was used.…”

Section: Place Conditioning Apparatus and Protocolmentioning

confidence: 99%

“…The camera was placed 2m above the CPP boxes and the locomotion tracking was measured by Maze Router homemade software, a video tracking system for automation of behavioral experiments. CPP paradigm took place for 5 continuous days, which consisted of three distinct phases: pre-conditioning, conditioning and postconditioning (5,6).…”

Section: Place Conditioning Apparatus and Protocolmentioning

confidence: 99%

“…3 rats were excluded from this study due to compartment preference. Then rats were randomly assigned to one of the two groups (odd and even) for place conditioning (45).…”

Section: Pre-conditioning Phasementioning

confidence: 99%

“…Recently, it has become progressively clear that glutamate is involved in addiction and that glutamatergic neurotransmission may be responsible for brain plastic changes that lead to addictive behavior and relapse (4). It is well established that glutamatergic neurotransmission in the mesocorticolimbic pathway is involved in different mechanisms of morphine dependence (5)(6)(7). Glutamate is the most abundant excitatory neurotransmitter in the brain and glutamatergic transmission accounts for up to 70% of synaptic transmission in the central nervous system (CNS) (8).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of the mGluR8 Agonist, S-3,4-DCPG on Acquisition and Expression of Morphine-Induced Conditioned Place Preference in Male Rats

Kahvandi

Ebrahimi

Karimi

et al. 2020

Preprint

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BackgroundThe nucleus accumbens (NAc) plays a principal role in drug reward. It has been reported that metabotropic glutamate receptors (mGluRs) play a key role in the rewarding pathway(s). Previous studies have shown the vast allocation of the different types of mGluRs, including mGluR8, in regions that are associated with opioid rewards, such as the NAc. The aim of the present study was to evaluate the role of mGlu8 receptors within the NAc in the acquisition and expression phases of morphine induced conditioned place preference (CPP). Adult male Wistar rats were bilaterally implanted by two cannulas' in the NAc and were evaluated in a CPP paradigm. Selective mGluR8 allosteric agonist (S-3,4-DCPG) was administered at doses of 0.03, 0.3, and 3μg/0.5 μL saline per side into the NAc on both sides during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase, or before place preference test, or post-conditioning (expression) phase of morphine-induced CPP. ResultsThe results revealed that intra-accumbal administration of S-3,4-DCPG (0.3 and 3 μg) markedly decreased the acquisition in a dose-dependent manner but had no effect on expression of morphine-induced CPP. ConclusionsThe findings suggest that activation of mGlu8 receptors in the NAc dose-dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine which may be related to the glutamate activity into the NAc and/or synaptic plasticity of this system in reward pathway(s).

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Section: Discussionmentioning

confidence: 99%

“…In this apparatus, rats showed no consistent preference for either compartment. The CPP protocol has been previously described (45). An unbiased allocation was used.…”

Section: Place Conditioning Apparatus and Protocolmentioning

confidence: 99%

Section: Place Conditioning Apparatus and Protocolmentioning

confidence: 99%

“…3 rats were excluded from this study due to compartment preference. Then rats were randomly assigned to one of the two groups (odd and even) for place conditioning (45).…”

Section: Pre-conditioning Phasementioning

confidence: 99%