Intra-Abdominal Venous and Arterial Thromboembolism in Inflammatory Bowel Disease

Fabio, Francesco Di; Obrand, Daniel I.; Satin, R; Gordon, Philip H.

doi:10.1007/dcr.0b013e31819a235d

Cited by 27 publications

(24 citation statements)

References 89 publications

(100 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microvascular endothelial dysfunction with diminished vasodilatory capacity causes reduced perfusion, impairs wound healing, and triggers inflammation in IBD (32). Venous and arterial thromboembolism is the major cause of morbidity and mortality in IBD patients (33). Some genetic factors and drugs used in treatment could also promote the pathophysiology of neuronal and vascular damage in IBD (34,35).…”

Section: Discussionmentioning

confidence: 99%

Visual evoked potentials and pulse wave velocity in inflammatory bowel disease

Aytaç

Büyüktaş²,

Baysal³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: Data about the effects of inflammatory bowel disease (IBD) on various functions of the nervous and cardiovascular systems are limited. In this study, the visual neuronal and cardiovascular functions of patients with IBD were evaluated by measuring visual evoked potentials (VEP) and pulse wave velocity (PWV), respectively. Materials and Methods: There were three study groups: the Crohn's disease (CD) group (n=25), the ulcerative colitis (UC) group (n=30), and a healthy control (C) group (n=25). The exclusion criteria were as follows: patients with IBD were in remission, had no extra-intestinal manifestations of the disease, had no additional chronic disease(s), and had been receiving medical treatment for their IBD without any previous surgical intervention. VEP amplitudes (mV) and the N2 and P2 latencies (ms) were recorded for visual-neuronal analysis of all study groups. For cardiovascular assessment in all study groups, PWV was measured noninvasively as follows: the carotid-femoral PWV with the Complior Colson device (The authors have no conflict of interest.) and the PWV along the aorta with two ultrasound strain-gauge pressure-sensitive transducers (TY-306 Fukuda pressure-sensitive transducers -Fukuda Denshi Co, Tokyo, Japan) fixed transcutaneously over the course of a pair of arteries separated by a known distance. The right femoral and right common carotid arteries were the ones used. Results: The PWV levels of the CD and UC groups were significantly higher than those in the C group (p<0.001). In the bilateral recording of the VEP, the N2 latencies of the CD (p<0.05) and UC (p<0.01) groups were significantly longer than those in the C group. Conclusion: In this study, we showed vascular and visual neuronal impairments at a subclinical stage in patients with both types of IBD.

show abstract

Section: Discussionmentioning

confidence: 99%

Visual evoked potentials and pulse wave velocity in inflammatory bowel disease

Aytaç

Büyüktaş²,

Baysal³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…In the first episode, 6 months' coverage is recommended, but it is extended if the risk factors have not disappeared (surgery or immobilization), lifelong anticoagulation in patients with an inherited hypercoagulable state. 16 The optimum duration of antibiotic therapy is also unclear, but a prolonged course is suggested on the assumption of difficult penetration of antibiotics into the infected thrombus.…”

Section: Discussionmentioning

confidence: 99%

Septic Pylephlebitis as a Rare Complication of Crohn's Disease

Shin

Lee

Kim

et al. 2013

Korean J Gastroenterol

View full text Add to dashboard Cite

Thrombophlebitis of the portal venous system (PVS) with superimposed bacterial infection (septic pylephlebitis) is an extremely rare complication of Crohn's disease (CD), and therefore diagnosis of septic pylephlebitis is difficult without high clinical suspicion. A 16-year old male patient who was diagnosed with CD 3 months earlier was admitted with recurrent fever and abdominal pain. CD activity had been well controlled with conventional medical treatment during a follow-up period. Abdominal contrast-enhanced computed tomography showed massive thrombosis in the PVS without evidence of intra-abdominal infection, and blood cultures were positive for Streptococcus viridians. There was no evidence of deep vein thrombosis or pulmonary thromboembolism, and all laboratory tests for thrombophilia were normal. Based on these findings, the patient was diagnosed with septic pylephlebitis complicated with CD, and was successfully treated with intravenous antibiotic therapy combined with anticoagulation. This case suggests that early comprehensive evaluation is crucial for immediate diagnosis and proper treatment of septic pylephlebitis in patients with CD who present with fever and abdominal pain of unknown origin, even with stable disease activity and absence of other intra-abdominal infections. (Korean J Gastroenterol 2013;61:219-224)

show abstract

“…It is plausible that the identification of steroid use as a risk factor is a surrogate marker for an underlying condition such as an autoimmune condition or inflammatory bowel disease that may predispose to thrombosis. 12,13 The category of "bleeding disorder" captures patients who are taking anticoagulants at the time of admission. By definition, this patient population is at increased risk of a future thromboembolic event because of underlying risk factors that precipitated the commencement of anticoagulation and because of the disruption of their anticoagulation regimen.…”

Section: Discussionmentioning

confidence: 99%