Intra-abdominal recurrence from colorectal carcinoma: Differences and similarities between local and peritoneal recurrence

Surgery of resectable local recurrence following colorectal cancer: Compartmental surgery improves local control

“…Thirdly, oncologic extensions are significantly different between LR and PM. Unlike PM, LR has an infiltrating progression which is associated with a high degree of local invasion and LN involvement 19,23 . A correct diagnosis of LR from colonic cancer is required because the therapeutic management of LR and PM has to be different.…”

“…Oncologic patterns of PM are more metastatic than local, with rare cure (only 16% of disease‐free survival at 5 years after cytoreduction) 26 . On the contrary, isolated LR has local spreading that is limited to adjacent organs 19 and aggressive local treatment is justified, allowing long survival (median OS: 60 months). Our findings suggest that CompRe could be offered to patients with LR and no PM.…”

“…Definitions and classifications of recurrent CRCs are heterogeneous 16 and differ depending on the anatomic position, i.e., colonic or rectal. The definition of LR in our study combined those of The American Joint Committee on Cancer (AJCC) 17 and The Union for International Cancer Control (UICC), 18 plus the definition of the beyond TME group 7 plus our 19–21 and other LR descriptions from previous studies 3,5,22 …”

Surgical management and hyperthermic intraperitoneal chemotherapy for locally advanced colorectal cancer

“…The role of CRS and HIPEC in the management of locally recurrent colorectal cancer is a matter of debate. While some consider local and peritoneal recurrences as a single entity, both representing indications for CRS & HIPEC (25); others frown upon the use of HIPEC in isolated local recurrences (26,27). Dumont et al in an attempt to differentiate the two compared the clinico-pathological characteristic of patients with local vs. peritoneal recurrence following CRS & HIPEC and found the former to have a higher likelihood of organ involvement and lymph node metastases and an increased mortality (27).…”

“…While some consider local and peritoneal recurrences as a single entity, both representing indications for CRS & HIPEC (25); others frown upon the use of HIPEC in isolated local recurrences (26,27). Dumont et al in an attempt to differentiate the two compared the clinico-pathological characteristic of patients with local vs. peritoneal recurrence following CRS & HIPEC and found the former to have a higher likelihood of organ involvement and lymph node metastases and an increased mortality (27). Limited data in this area precludes us from making any firm conclusions, suggesting the need for future prospective studies to differentiate the two during the selection of patients for CRS and HIPEC.…”